Search Results - "Knippenberg, R W"

Effect of MDL 105,212, a nonpeptide NK-1/NK-2 receptor antagonist in an allergic guinea pig model by Kudlacz, E M, Knippenberg, R W, Logan, D E, Burkholder, T P

“…MDL 105,212 has been identified as a potent, nonpeptide NK-1 and NK-2 receptor antagonist that inhibits effects of substance P and neurokinin A in vitro and in…”
Get more information

In vitro and in vivo characterization of MDL 105,212A, a nonpeptide NK-1/NK-2 tachykinin receptor antagonist by Kudlacz, E M, Shatzer, S A, Knippenberg, R W, Logan, D E, Poirot, M, van Giersbergen, P L, Burkholder, T P

“…We have identified and characterized a novel, potent, nonselective tachykinin receptor antagonist, MDL 105,212A [(R)-1-[2-[3-(3,4-…”
Get more information

Circulating factors contribute to elevation of intracellular cyclic-3',5'-adenosine monophosphate and depression of superoxide anion production in polymorphonuclear leukocytes following thermal injury by Bjornson, A B, Somers, S D, Knippenberg, R W, Bjornson, H S

“…We have previously demonstrated that bactericidal activity and superoxide anion (O2-) production are depressed concomitantly in polymorphonuclear leukocytes…”
Get more information

In vitro and in vivo effects of tachykinins on immune cell function in guinea pig airways by Kudlacz, E M, Knippenberg, R W

“…The effects of sensory neuropeptides substance P (SP) and neurokinin A (NKA) on immune cell recruitment and macrophage activation were determined. Guinea pigs…”
Get more information

Nonsteroidal Anti-Inflammatory Drugs Correct the Bactericidal Defect of Polymorphonuclear Leukocytes in a Guinea Pig Model of Thermal Injury by Bjornson, Ann B., Knippenberg, Robert W., Bjornson, H. Stephen

“…We conducted studies to determine the effects of parenteral therapy with indomethacin, ibuprofen, and piroxicam on key immunologic and hematologic alterations…”
Get full text

Bactericidal defect of neutrophils in a guinea pig model of thermal injury is related to elevation of intracellular cyclic-3',5'-adenosine monophosphate by Bjornson, AB, Knippenberg, RW, Bjornson, HS

“…PG of the E series inhibit major effector functions of polymorphonuclear leukocytes (PMN) by elevating intracellular cAMP. The present study investigated the…”
Get full text

The peripheral NK-1/NK-2 receptor antagonist MDL 105,172A inhibits tachykinin-mediated respiratory effects in guinea-pigs by Kudlacz, E M, Knippenberg, R W, Shatzer, S A, Kehne, J H, McCloskey, T C, Burkholder, T P

“…1. Stimulation of sensory nerves causes release of tachykinins, including substance P (SP) and neurokinin A (NKA), which produce a variety of respiratory…”
Get more information

Synthesis and structure-activity relationships for a series of substituted pyrrolidine NK1/NK2 receptor antagonists by BURKHOLDER, T. P, KUDLACZ, E. M, BRATTON, L, GROSS, R. S, KNIPPENBERG, R. W, LOGAN, D. E, JONES, B. K, CHEN, T.-M, GEARY, J. L, CORREL, M. A, POOLE, J. C, MANDAGARE, A. K, MAYNARD, G. D, THOMPSON, T. N, HWANG, K.-K, LIU, X.-G, LE, T.-B, WEBSTER, M. E, HORGAN, S. W, WENSTRUP, D. L, FREUND, D. W, BOYER, F

Get full text

Parainfluenza virus type-3 infection attenuates the respiratory effects of antigen challenge in sensitized guinea pigs by Kudlacz, E M, Knippenberg, R W

“…Respiratory viral infections not only exacerbate asthma symptoms but may also be important in the pathogenesis of the disease. We therefore explored the…”
Get full text

Temporal Relationships Among Immunologic Alterations in a Guinea Pig Model of Thermal Injury by Bjornson, Ann B., Bjornson, H. Stephen, Knippenberg, Robert W., Cardone, J. Scott

“…Temporal relationships among various humoral and cellular alterations of host defense mechanisms were investigated in a guinea pig model of thermal injury…”
Get full text

Use of CoMFA in validating the conformation used in designing 4-(1H-benzimidazole-2-carbonyl)piperidines with H1/NK1 receptor antagonist activity by VAZ, R. J, MAYNARD, G. D, KUDLACZ, E. M, BRATTON, L. D, KANE, J. M, SHATZER, S. A, KNIPPENBERG, R. W

Get full text

Synthesis and SAR of 4-(1H-benzimidazole-2-carbonyl)piperidines with dual histamine H1/Tachykinin NK1 receptor antagonist activity by MAYNARD, G. D, BRATTON, L. D, LOGAN, D. E, KANE, J. M, BURKHOLDER, T. P, SANTIAGO, B, STEWART, K. T, KUDLACZ, E. M, SHATZER, S. A, KNIPPENBERG, R. W, FARRELL, A. M

Get full text

Identification and chemical synthesis of MDL 105,212, a non-peptide tachykinin antagonist with high affinity for NK1 and NK2 receptors by Burkholder, Timothy P., Kudlacz, Elizabeth M., Tieu-Binh Le, Knippenberg, Robert W., Shatzer, Scott A., Maynard, George D., Webster, Mark E., Horgan, Stephen W.

Get full text

Temporal relationship among immunologic alterations in a guinea pig model of thermal injury by BJORNSON, A. B, BJORNSON, H. S, KNIPPENBERG, R. W, SCOTT CARDONE, J

Get full text