Search Results - "Knippels, L M J"

Galectin-9 induced by dietary synbiotics is involved in suppression of allergic symptoms in mice and humans by de Kivit, S., Saeland, E., Kraneveld, A. D., van de Kant, H. J. G., Schouten, B., van Esch, B. C. A. M., Knol, J., Sprikkelman, A. B., van der Aa, L. B., Knippels, L. M. J., Garssen, J., van Kooyk, Y., Willemsen, L. E. M.

“…: Background: Prebiotic galacto‐ and fructo‐oligosaccharides (scGOS/lcFOS) resembling non‐digestible oligosaccharides in human milk reduce the development of…”
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Synbiotics prevent asthma-like symptoms in infants with atopic dermatitis by van der Aa, L.B, van Aalderen, W.M.C, Heymans, H.S.A, Henk Sillevis Smitt, J, Nauta, A.J, Knippels, L.M.J, Ben Amor, K, Sprikkelman, A.B

“…To cite this article: van der Aa LB, van Aalderen WMC, Heymans HSA, Henk Sillevis Smitt J, Nauta AJ, Knippels LMJ, Ben Amor K, Sprikkelman AB, the Synbad Study…”
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Oral treatment with probiotics reduces allergic symptoms in ovalbumin-sensitized mice: a bacterial strain comparative study by Hougee, S, Vriesema, A J M, Wijering, S C, Knippels, L M J, Folkerts, G, Nijkamp, F P, Knol, J, Garssen, J

“…Evidence demonstrating an important role of the intestinal microbiota in the incidence of allergic disorders has led to the concept of using probiotics as…”
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Non-digestible oligosaccharides modulate intestinal immune activation and suppress cow's milk allergic symptoms by Kerperien, J., Jeurink, P. V., Wehkamp, T., van der Veer, A., van de Kant, H. J. G., Hofman, G. A., van Esch, E. C. A. M., Garssen, J., Willemsen, L. E. M., Knippels, L. M. J.

“…Background Cow's milk allergy is a common food allergy in childhood and no effective preventive or curative treatment is available. This study aimed at…”
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No detectable beneficial systemic immunomodulatory effects of a specific synbiotic mixture in infants with atopic dermatitis by van der Aa, L. B., Lutter, R., Heymans, H. S. A., Smids, B. S., Dekker, T., van Aalderen, W. M. C., Sillevis Smitt, J. H., Knippels, L. M. J., Garssen, J., Nauta, A. J., Sprikkelman, A. B.

“…Summary Background In a murine model of allergic inflammation, Bifidobacterium breve M‐16V has been shown to reduce IL‐4 and IgE by inducing IL‐10 and IFN‐γ…”
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The Effect of the Food Matrix on In Vivo Immune Responses to Purified Peanut Allergens by van Wijk, F., Nierkens, S., Hassing, I., Feijen, M., Koppelman, S. J., de Jong, G. A. H., Pieters, R, Knippels, L. M. J.

“…There is little knowledge about the factors that determine the allergenicity of food proteins. One aspect that remains to be elucidated is the effect of the…”
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CD4+CD25+ T cells regulate the intensity of hypersensitivity responses to peanut, but are not decisive in the induction of oral sensitization by Van Wijk, F., Wehrens, E. J. M., Nierkens, S., Boon, L., Kasran, A., Pieters, R., Knippels, L. M. J.

“…Summary Background Naturally occurring CD4+CD25+ regulatory T cells (Tregs) play a critical role in the maintenance of self‐tolerance and it has been suggested…”
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Quantification of major peanut allergens Ara h 1 and
Ara h 2 in the peanut varieties Runner, Spanish, Virginia,
and Valencia, bred in different parts of the world by Koppelman, S. J., Vlooswijk, R. A. A., Knippels, L. M. J., Hessing, M., Knol, E. F., Van Reijsen, F. C., Bruijnzeel‐Koomen, C. A. F. M.

“…Background: The serology of peanut allergy seems to be different in various parts of the world. We analyzed the composition of 13 samples of three varieties of…”
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Depletion of CD4+CD25+ T cells switches the whey-allergic response from immunoglobulin E- to immunoglobulin free light chain-dependent by Van Esch, B. C. A. M., Schouten, B., Blokhuis, B. R. J., Hofman, G. A., Boon, L., Garssen, J., Knippels, L. M. J., Willemsen, L. E. M., Redegeld, F. A.

“…Summary Background Symptoms of allergy are largely attributed to an IgE‐mediated hypersensitivity response. However, a considerable number of patients also…”
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Human milk: a source of more life than we imagine by Jeurink, P V, van Bergenhenegouwen, J, Jiménez, E, Knippels, L M J, Fernández, L, Garssen, J, Knol, J, Rodríguez, J M, Martín, R

“…The presence of bacteria in human milk has been acknowledged since the seventies. For a long time, microbiological analysis of human milk was only performed in…”
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Early life: gut microbiota and immune development in infancy by Martin, R, Nauta, A J, Ben Amor, K, Knippels, L M J, Knol, J, Garssen, J

“…The immune system of infants is actively downregulated during pregnancy and therefore the first months of life represent a period of heightened susceptibility…”
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A multi-center assessment to compare residual allergenicity of partial hydrolyzed whey proteins in a murine model for cow’s milk allergy – Comparison to the single parameter guinea pig model by van Esch, B.C.A.M., van Bilsen, J.H.M., Gros- van Hest, M., Kleinjans, L., Belzer, C., Jeurink, P.V., Garssen, J., Smit, J.J., Pieters, R.H.H., Knippels, L.M.J.

“…•Safety assessment of infant formulas requires testing of residual allergenicity.•Multi-parameter murine model is preferred over single-parameter guinea pig…”
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The evaluation of the immunomodulating properties of ERA-63 a pharmaceutical with estrogenic activity by Janssen, G.B., Penninks, A.H., Knippels, L.M.J., van Zijverden, M., Spanhaak, S.

“…This paper describes studies performed with ERA-63 a low molecular weight pharmaceutical with intended immunomodulatory effects. Since this compound was also…”
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Cord blood IgE: fetal or maternal? by Meulenbroek, L. A. P. M., Knippels, L. M. J.

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Interlaboratory evaluation of a cow's milk allergy mouse model to assess the allergenicity of hydrolysed cow's milk based infant formulas by van Esch, B.C.A.M., van Bilsen, J.H.M., Jeurink, P.V., Garssen, J., Penninks, A.H., Smit, J.J., Pieters, R.H.H., Knippels, L.M.J.

“…•Mouse model to assess allergenicity of hydrolysed cow's milk based infant formulas.•Two phases of a multicenter project performed in four independent research…”
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The degree of whey hydrolysis does not uniformly affect in vitro basophil and T cell responses of cow's milk-allergic patients by Meulenbroek, L. A. P. M., Oliveira, S., den Hartog Jager, C. F., Klemans, R. J. B., Lebens, A. F. M., van Baalen, T., Knulst, A. C., Bruijnzeel-Koomen, C. A. F. M., Garssen, J., Knippels, L. M. J., van Hoffen, E.

“…Summary Background Several studies investigated whether hydrolysed proteins can induce tolerance to cow's milk (CM) in children at risk of developing CM…”
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Mice co-administrated with partially hydrolysed whey proteins and prebiotic fibre mixtures show allergen-specific tolerance and a modulated gut microbiota by Kleinjans, L, Veening-Griffioen, D H, Wehkamp, T, van Bergenhenegouwen, J, Knol, J, Garssen, J, Knippels, L M J, Belzer, C, Jeurink, P V

“…Non-breastfed infants at-risk of allergy are recommended to use a hydrolysed formula before the age of 6 months. The addition of prebiotics to this formula may…”
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Review of animal models designed to predict the potential allergenicity of novel proteins in genetically modified crops by Ladics, G.S., Knippels, L.M.J., Penninks, A.H., Bannon, G.A., Goodman, R.E., Herouet-Guicheney, C.

“…The safety assessment of genetically modified crops involves the evaluation of the potential allergenicity of novel proteins by using several in silico and in…”
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Effects of short-chain galacto- and long-chain fructo-oligosaccharides on systemic and local immune status during pregnancy by van Vlies, N, Hogenkamp, A, Thijssen, S, Dingjan, G.M, Knipping, K, Garssen, J, Knippels, L.M.J

“…Abstract Nondigestible oligosaccharides can positively influence health via various mechanisms. During pregnancy, supplementation of nondigestible…”
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Mixed antibody and T cell responses to peanut and the peanut allergens Ara h 1, Ara h 2, Ara h 3 and Ara h 6 in an oral sensitization model by Van Wijk, F., Hartgring, S., Koppelman, S. J., Pieters, R., Knippels, L. M. J.

“…Summary Background Peanut allergy is known for its severity and persistence through life. Several peanut proteins have been identified as allergenic and are…”
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