Search Results - "Knippels, Léon M.J."

Cow milk allergy symptoms are reduced in mice fed dietary synbiotics during oral sensitization with whey by Schouten, Bastiaan, van Esch, Betty C A M, Hofman, Gerard A, van Doorn, Suzan A C M, Knol, Jan, Nauta, Alma J, Garssen, Johan, Willemsen, Linette E M, Knippels, Léon M J

“…Cow milk allergy is the most common food allergy in children. So far, no effective treatment is available to prevent or cure food allergy. The purpose of this…”
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Serum biomarkers for allergy in children by Knipping, Karen, Knippels, Léon M.J., Dupont, Christophe, Garssen, Johan

“…A large number of studies investigating various biomarkers for allergy have been published over the past decades. The aim of this review was to evaluate these…”
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DCIR interacts with ligands from both endogenous and pathogenic origin by Bloem, Karien, Vuist, Ilona M, van den Berk, Meike, Klaver, Elsenoor J, van Die, Irma, Knippels, Léon M.J, Garssen, Johan, García-Vallejo, Juan J, van Vliet, Sandra J, van Kooyk, Yvette

“…Highlights • We compared the glycan specificity of the DC-expressed CLRs: DCIR and DC-SIGN. • DCIR and DC-SIGN have overlapping glycan specificities. • Novel…”
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Oligosaccharide-induced whey-specific CD25(+) regulatory T-cells are involved in the suppression of cow milk allergy in mice by Schouten, Bastiaan, van Esch, Betty C A M, Hofman, Gerard A, Boon, Louis, Knippels, Léon M J, Willemsen, Linette E M, Garssen, Johan

“…Dietary intervention with a unique prebiotic nondigestible carbohydrate mixture has been shown to reduce the development of allergic disease in infants at…”
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Food-derived oligosaccharides exhibit pharmaceutical properties by Rijnierse, Anneke, Jeurink, Prescilla V., van Esch, Betty C.A.M., Garssen, Johan, Knippels, Léon M.J.

“…Breast feeding is considered as the best nutrition for growth and development of an infant. Human milk consists of a unique combination of nutritional…”
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In vivo and in vitro evaluation of the residual allergenicity of partially hydrolysed infant formulas by van Esch, Betty C.A.M., Knipping, Karen, Jeurink, Prescilla, van der Heide, Sicco, Dubois, Anthony E.J., Willemsen, Linette E.M., Garssen, Johan, Knippels, Léon M.J.

“…Hypoallergenic infant formulas are commonly used for genetically predisposed children and infants diagnosed with cow's milk allergy. This study describes both…”
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Contribution of IgE and immunoglobulin free light chain in the allergic reaction to cow's milk proteins by Schouten, Bastiaan, PhD, van Esch, Betty C.A.M., BSc, van Thuijl, Anders O.J., MD, Blokhuis, Bart R.J., BSc, Groot Kormelink, Tom, MSc, Hofman, Gerard A., BSc, Moro, Guido E., MD, PhD, Boehm, Günther, MD, PhD, Arslanoglu, Sertac, MD, PhD, Sprikkelman, Aline B., MD, PhD, Willemsen, Linette E.M., PhD, Knippels, Léon M.J., PhD, Redegeld, Frank A., PhD, Garssen, Johan, PhD

“…Background Cow's milk allergy (CMA) affects 2.5% of young infants. In previous murine studies it was observed that allergic sensitization to the major cow's…”
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Recent advances using rodent models for predicting human allergenicity by Knippels, Léon M.J., Penninks, André H.

“…The potential allergenicity of newly introduced proteins in genetically engineered foods has become an important safety evaluation issue. However, to evaluate…”
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Lactobacillus casei Shirota does not decrease the food allergic response to peanut extract in Brown Norway rats by de Jonge, Jonathan D, Ezendam, Janine, Knippels, Léon M.J, Penninks, André H, Pieters, Raymond, van Loveren, Henk

“…Abstract Probiotics are claimed to beneficially affect the immune system and their involvement in allergy prevention is being investigated extensively…”
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Supplementation of dietary non-digestible oligosaccharides from birth onwards improve social and reduce anxiety-like behaviour in male BALB/c mice by Szklany, Kirsten, Wopereis, Harm, de Waard, Cindy, van Wageningen, Thecla, An, Ran, van Limpt, Kees, Knol, Jan, Garssen, Johan, Knippels, Leon M. J., Belzer, Clara, Kraneveld, Aletta D.

“…Objective: The intestinal microbiota is acknowledged to be essential in brain development and behaviour. Their composition can be modulated by prebiotics such…”
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Fecal secretory immunoglobulin A is increased in healthy infants who receive a formula with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides by Scholtens, Petra A M J, Alliet, Philippe, Raes, Marc, Alles, Martine S, Kroes, Hilde, Boehm, Guenther, Knippels, Leon M J, Knol, Jan, Vandenplas, Yvan

“…In this double-blind, randomized, placebo-controlled study, we investigated the effect of an infant milk formula with 6 g/L short-chain galacto- and long-chain…”
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Dietary Vitamin D Supplementation Is Ineffective in Preventing Murine Cow's Milk Allergy, Irrespective of the Presence of Nondigestible Oligosaccharides by Kerperien, JoAnn, Veening-Griffioen, Désirée, Oja, Anna, Wehkamp, Tjalling, Jeurink, Prescilla V, Garssen, Johan, Knippels, Leon M J, Willemsen, Linette E M

“…Cow's milk allergy (CMA) is one of the most common food allergies especially early in life. A mixture of nondigestible short-chain galacto-oligosaccharides,…”
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Bis(tributyltin)oxide (TBTO) decreases the food allergic response against peanut and ovalbumin in Brown Norway rats by de Jonge, Jonathan D, Ezendam, Janine, Knippels, Léon M.J, Odink, Jennie, Pourier, Milanthy S, Penninks, André H, Pieters, Raymond, van Loveren, Henk

“…Abstract Other factors than the allergen itself may be of importance in the development of food allergy. This report describes the influence of the…”
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Immune-Mediated Effects upon Oral Challenge of Ovalbumin-Sensitized Brown Norway Rats: Further Characterization of a Rat Food Allergy Model by Knippels, Léon M.J., Penninks, André H., Smit, Joost J., Houben, Geert F.

“…Although severalin vivoantigenicity assays using parenteral immunization are operational, no full validated enteral models are available to study food allergy…”
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Mechanisms underlying immune effects of dietary oligosaccharides by Jeurink, Prescilla V, van Esch, Betty CAM, Rijnierse, Anneke, Garssen, Johan, Knippels, Léon MJ

“…The WHO refers to human milk as the nutritional gold standard for term infants. Human milk contains many immunomodulatory compounds, including…”
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Identification of peptides with tolerogenic potential in a hydrolysed whey‐based infant formula by Gouw, Joost W., Jo, Juandy, Meulenbroek, Laura A. P. M., Heijjer, T. Sam, Kremer, Erica, Sandalova, Elena, Knulst, André C., Jeurink, Prescilla V., Garssen, Johan, Rijnierse, Anneke, Knippels, Léon M. J.

“…Summary Background Failure to induce oral tolerance may result in food allergy. Hydrolysed cow's milk‐based infant formulas are recommended in subjects with a…”
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Butyrate Enhances Desensitization Induced by Oral Immunotherapy in Cow’s Milk Allergic Mice by van Esch, Betty C. A. M., Knippels, Leon, Pieters, Raymond H. H., Smit, Joost J., Wagenaar, Laura, Diks, Mara A. P., Blokhuis, B. R., Vonk, Marlotte M., Garssen, J.

“…Background. In previous studies, we showed that a fructo-oligosaccharide- (FOS-) supplemented diet enhanced oral immunotherapy (OIT) efficacy in a mouse model…”
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Improved Efficacy of Oral Immunotherapy Using Non-Digestible Oligosaccharides in a Murine Cow's Milk Allergy Model: A Potential Role for Foxp3+ Regulatory T Cells by Vonk, Marlotte M, Diks, Mara A P, Wagenaar, Laura, Smit, Joost J, Pieters, Raymond H H, Garssen, Johan, van Esch, Betty C A M, Knippels, Léon M J

“…Oral immunotherapy (OIT) is a promising therapeutic approach to treat food allergic patients. However, there are some concerns regarding its safety and…”
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Decreased Histone Acetylation Levels at Th1 and Regulatory Loci after Induction of Food Allergy by Alashkar Alhamwe, Bilal, Meulenbroek, Laura A P M, Veening-Griffioen, Désirée H, Wehkamp, Tjalling M D, Alhamdan, Fahd, Miethe, Sarah, Harb, Hani, Hogenkamp, Astrid, Knippels, Léon M J, Pogge von Strandmann, Elke, Renz, Harald, Garssen, Johan, van Esch, Betty C A M, Garn, Holger, Potaczek, Daniel P, Tiemessen, Machteld M

“…Immunoglobulin E (IgE)-mediated allergy against cow's milk protein fractions such as whey is one of the most common food-related allergic disorders of early…”
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A Specific Mixture of Fructo-Oligosaccharides and Bifidobacterium breve M-16V Facilitates Partial Non-Responsiveness to Whey Protein in Mice Orally Exposed to β-Lactoglobulin-Derived Peptides by Kostadinova, Atanaska I, Meulenbroek, Laura A P M, van Esch, Betty C A M, Hofman, Gerard A, Garssen, Johan, Willemsen, Linette E M, Knippels, Léon M J

“…Oral tolerance is a promising approach for allergy prevention in early life, but it strongly depends on allergen exposure and proper immune environment. Small…”
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