Search Results - "Knights, Alexander J"

The Heating Microenvironment: Intercellular Cross Talk Within Thermogenic Adipose Tissue by Knights, Alexander J, Wu, Jun, Tseng, Yu-Hua

“…Adipose tissue serves as the body's primary energy storage site; however, findings in recent decades have transformed our understanding of the multifaceted…”
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Temporal dynamics of immune-stromal cell interactions in fracture healing by Capobianco, Christina A, Hankenson, Kurt D, Knights, Alexander J

“…Bone fracture repair is a complex, multi-step process that involves communication between immune and stromal cells to coordinate the repair and regeneration of…”
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Signaling through the nicotinic acetylcholine receptor in the liver protects against the development of metabolic dysfunction-associated steatohepatitis by Jun, Heejin, Liu, Shanshan, Knights, Alexander J, Zhu, Kezhou, Ma, Yingxu, Gong, Jianke, Lenhart, Ashley E, Peng, Xiaoling, Huang, Yunying, Ginder, Jared P, Downie, Christopher H, Ramos, Erika Thalia, Kullander, Klas, Kennedy, Robert T, Xu, X Z Shawn, Wu, Jun

“…Metabolic dysfunction-associated steatohepatitis (MASH) is the progressive form of liver steatosis, the most common liver disease, and substantially increases…”
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Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3) by Knights, Alexander J., Vohralik, Emily J., Houweling, Peter J., Stout, Elizabeth S., Norton, Laura J., Alexopoulos, Stephanie J., Yik, Jinfen. J., Mat Jusoh, Hanapi, Olzomer, Ellen M., Bell-Anderson, Kim S., North, Kathryn N., Hoehn, Kyle L., Crossley, Merlin, Quinlan, Kate G. R.

“…The conversion of white adipocytes to thermogenic beige adipocytes represents a potential mechanism to treat obesity and related metabolic disorders. However,…”
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Loss of Krüppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/Clqdc2) by BELL-ANDERSON, Kim S, FUNNELL, Alister P, NICHOLAS, Hannah R, SAINSBURY, Amanda, TURNER, Nigel, PEARSON, Richard C, CROSSLEY, Merlin, WILLIAMS, Helen, HANAPI MAT JUSOH, SCULLY, Tiffany, LIM, Wooi F, BURDACH, Jon G, KA SIN MAK, KNIGHTS, Alexander J, HOY, Andrew J

“…Krüppel-like factor 3 (KLF3) is a transcriptional regulator that we have shown to be involved in the regulation of adipogenesis in vitro. Here, we report that…”
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Inflammation in osteoarthritis: the latest progress and ongoing challenges by Knights, Alexander J., Redding, Stephen J., Maerz, Tristan

“…The understanding of inflammation in osteoarthritis is rapidly evolving. This review highlights important basic science, mechanistic, and clinical findings…”
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Partial reprogramming of heterologous cells by defined factors to generate megakaryocyte lineage-restricted biomolecules by Artuz, Crisbel M., Knights, Alexander J., Funnell, Alister P.W., Gonda, Thomas J., Ravid, Katya, Pearson, Richard C.M., Quinlan, Kate G.R., Crossley, Merlin

“…•GATA1 and FLI1 switch on the endogenous platelet factor 4 (Pf4) gene in fibroblasts.•Pf4 expression is maintained and increases over time.•PF4 protein is…”
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Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 in osteoarthritis by Knights, Alexander J, Farrell, Easton C, Ellis, Olivia M, Lammlin, Lindsey, Junginger, Lucas M, Rzeczycki, Phillip M, Bergman, Rachel F, Pervez, Rida, Cruz, Monique, Knight, Eleanor, Farmer, Dennis, Samani, Alexa A, Wu, Chia-Lung, Hankenson, Kurt D, Maerz, Tristan

“…Synovium is acutely affected following joint trauma and contributes to post-traumatic osteoarthritis (PTOA) progression. Little is known about discrete cell…”
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Acetylcholine‐synthesizing macrophages in subcutaneous fat are regulated by β2‐adrenergic signaling by Knights, Alexander J, Liu, Shanshan, Ma, Yingxu, Nudell, Victoria S, Perkey, Eric, Sorensen, Matthew J, Kennedy, Robert T, Maillard, Ivan, Ye, Li, Jun, Heejin, Wu, Jun

“…Non‐neuronal cholinergic signaling, mediated by acetylcholine, plays important roles in physiological processes including inflammation and immunity. Our group…”
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Blood and adipose-resident eosinophils are defined by distinct transcriptional profiles by Shah, Manan, Knights, Alexander J, Vohralik, Emily J, Psaila, Annalise M, Quinlan, Kate G R

“…Eosinophils are granular leukocytes of the innate immune system that play important functions in host defense. Inappropriate activation of eosinophils can…”
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Adrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat Activation by Jun, Heejin, Ma, Yingxu, Chen, Yong, Gong, Jianke, Liu, Shanshan, Wang, Jine, Knights, Alexander J., Qiao, Xiaona, Emont, Margo P., Xu, X.Z. Shawn, Kajimura, Shingo, Wu, Jun

“…Maintaining energy homeostasis upon environmental challenges, such as cold or excess calorie intake, is essential to the fitness and survival of mammals. Drug…”
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Characterization of Glucose Transporter 6 in Lipopolysaccharide-Induced Bone Marrow-Derived Macrophage Function by Caruana, Beth T, Byrne, Frances L, Knights, Alexander J, Quinlan, Kate G R, Hoehn, Kyle L

“…The polarization processes for M1 versus M2 macrophages are quite distinct in the context of changes in cellular metabolism. M1 macrophages are highly…”
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Protein Arginine Methyltransferase 1 Interacts With PGC1α and Modulates Thermogenic Fat Activation by Qiao, Xiaona, Kim, Dong-Il, Jun, Heejin, Ma, Yingxu, Knights, Alexander J, Park, Min-Jung, Zhu, Kezhou, Lipinski, Jay H, Liao, Jiling, Li, Yiming, Richard, Stéphane, Weinman, Steven A, Wu, Jun

“…Protein arginine methyltransferases (PRMTs) are enzymes that regulate the evolutionarily conserved process of arginine methylation. It has been reported that…”
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EoTHINophils: Eosinophils as key players in adipose tissue homeostasis by Vohralik, Emily J., Psaila, Annalise M., Knights, Alexander J., Quinlan, Kate G. R.

“…Eosinophils are granular cells of the innate immune system that are found in almost all vertebrates and some invertebrates. Knowledge of their wide‐ranging…”
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Defining Eosinophil Function in Adiposity and Weight Loss by Knights, Alexander J., Vohralik, Emily J., Hoehn, Kyle L., Crossley, Merlin, Quinlan, Kate G. R.

“…Despite promising early work into the role of immune cells such as eosinophils in adipose tissue (AT) homeostasis, recent findings revealed that elevating the…”
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Krüppel-like factor 3 (KLF3) suppresses NF-κB–driven inflammation in mice by Knights, Alexander J., Yang, Lu, Shah, Manan, Norton, Laura J., Green, Gamran S., Stout, Elizabeth S., Vohralik, Emily J., Crossley, Merlin, Quinlan, Kate G.R.

“…Bacterial products such as lipopolysaccharides (or endotoxin) cause systemic inflammation, resulting in a substantial global health burden. The onset,…”
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Krüppel-like Factor 3 (KLF3/BKLF) Is Required for Widespread Repression of the Inflammatory Modulator Galectin-3 (Lgals3) by Knights, Alexander J., Yik, Jinfen J., Mat Jusoh, Hanapi, Norton, Laura J., Funnell, Alister P.W., Pearson, Richard C.M., Bell-Anderson, Kim S., Crossley, Merlin, Quinlan, Kate G.R.

“…The Lgals3 gene encodes a multifunctional β-galactoside-binding protein, galectin-3. Galectin-3 has been implicated in a broad range of biological processes…”
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Phosphorylation of Krüppel-like Factor 3 (KLF3/BKLF) and C-terminal Binding Protein 2 (CtBP2) by Homeodomain-interacting Protein Kinase 2 (HIPK2) Modulates KLF3 DNA Binding and Activity by Dewi, Vitri, Kwok, Alister, Lee, Stella, Lee, Ming Min, Tan, Yee Mun, Nicholas, Hannah R., Isono, Kyo-ichi, Wienert, Beeke, Mak, Ka Sin, Knights, Alexander J., Quinlan, Kate G.R., Cordwell, Stuart J., Funnell, Alister P.W., Pearson, Richard C.M., Crossley, Merlin

“…Krüppel-like factor 3 (KLF3/BKLF), a member of the Krüppel-like factor (KLF) family of transcription factors, is a widely expressed transcriptional repressor…”
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Adipokines and insulin action: A sensitive issue by Knights, Alexander J, Funnell, Alister PW, Pearson, Richard CM, Crossley, Merlin, Bell-Anderson, Kim S

“…Obesity is a major public health concern and a strong risk factor for insulin resistance, type 2 diabetes mellitus (T2DM), and cardiovascular disease. The last…”
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Cannabinoid receptor type 2 is upregulated in synovium following joint injury and mediates anti-inflammatory effects in synovial fibroblasts and macrophages by Rzeczycki, P., Rasner, C., Lammlin, L., Junginger, L., Goldman, S., Bergman, R., Redding, S., Knights, A.J., Elliott, M., Maerz, T.

“…Joint injury-induced perturbations to the endocannabinoid system (ECS), a regulator of both inflammation and nociception, remain largely uncharacterized. We…”
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