Search Results - "Knighton, D R"

Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase by Knighton, Daniel R., Zheng, Jianhua, Lynn F. Ten Eyck, Ashford, Victor A., Xuong, Nguyen-Huu, Taylor, Susan S., Sowadski, Janusz M.

“…The crystal structure of the catalytic subunit of cyclic adenosine monophosphate--dependent protein kinase complexed with a 20-amino acid substrate analog…”
Get full text

Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor by JIANHUA ZHENG, KNIGHTON, D. R, TEN EYCK, L. F, KARLSSON, R, NGUYEN-HUU XUONG, TAYLOR, S. S, SOWADSKI, J. M

“…The structure of a ternary complex of the catalytic subunit of cAMP-dependent protein kinase, MgATP, and a 20-residue inhibitor peptide was determined at a…”
Get full text

Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase by Knighton, Daniel R., Zheng, Jianhua, Lynn F. Ten Eyck, Xuong, Nguyen-Huu, Taylor, Susan S., Sowadski, Janusz M.

“…The structure of a 20-amino acid peptide inhibitor bound to the catalytic subunit of cyclic AMP-dependent protein kinase, and its interactions with the enzyme,…”
Get full text

Crystal structures of the myristylated catalytic subunit of cAMP‐dependent protein kinase reveal open and closed conformations by Zheng, Jianhua, Knighton, Daniel R., Taylor, Susan S., Xuong, Nguyen‐Huu, Sowadski, Janusz M., Eyck, Lynn F. Ten

“…Three crystal structures, representing two distinct conformational states, of the mammalian catalytic subunit of cAMP‐dependent protein kinase were solved…”
Get full text

Classification and treatment of chronic nonhealing wounds: successful treatment with autologous platelet-derived wound healing factors (PDWHF) by KNIGHTON, D. R, FIEGEL, V. D, AUSTIN, L. L, CIRESI, K. F, BUTLER, E. L

“…Previous animal data showed that platelets contain growth factors that stimulate capillary endothelial migration (angiogenesis), fibroblast proliferation and…”
Get full text

Systematic mutational analysis of cAMP-dependent protein kinase identifies unregulated catalytic subunits and defines regions important for the recognition of the regulatory subunit by Gibbs, C.S. (South San Francisco, CA), Knighton, D.R, Sowadski, J.M, Taylor, S.S, Zoller, M.J

“…A library of mutants of the catalytic subunit of the Saccharomyces cerevisiae cAMP-dependent protein kinase was screened in vitro for mutants defective in the…”
Get full text

Structural Features that Specify Tyrosine Kinase Activity Deduced from Homology Modeling of the Epidermal Growth Factor Receptor by Knighton, Daniel R., Cadena, Deborah L., Zheng, Jianhua, Lynn F. Ten Eyck, Taylor, Susan S., Sowadski, Janusz M., Gill, Gordon N.

“…To identify structural features that distinguish protein-tyrosine kinases from protein-serine kinases, a molecular model of the kinase domain of epidermal…”
Get full text

Studies on inflammation and wound healing: angiogenesis and collagen synthesis stimulated in vivo by resident and activated wound macrophages by Hunt, T K, Knighton, D R, Thakral, K K, Goodson, 3rd, W H, Andrews, W S

“…Wound inflammatory cells were harvested by aspiration of fluid from the "dead space" of subcutaneous rabbit wounds and transplanted into the cornea where,…”
Get more information

A three-dimensional model of the Cdc2 protein kinase: localization of cyclin- and Suc1-binding regions and phosphorylation sites by MARCOTTE, M. J, KNIGHTON, D. R, BASI, G, SOWADSKI, J. M, BRAMBILLA, P, DRAETTA, G, TAYLOR, S. S

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Structural Basis of the Intrasteric Regulation of Myosin Light Chain Kinases by Knighton, Daniel R., Pearson, Richard B., Sowadski, Janusz M., Means, Anthony R., Lynn F. Ten Eyck, Taylor, Susan S., Kemp, Bruce E.

“…The smooth muscle myosin light chain kinase (smMLCK) catalytic core was modeled by using the crystallographic coordinates of the cyclic AMP-dependent protein…”
Get full text

CAMP-dependent protein kinase: prototype for a family of enzymes by Taylor, S S, Bubis, J, Toner-Webb, J, Saraswat, L D, First, E A, Buechler, J A, Knighton, D R, Sowadski, J

“…Protein kinases represent a diverse family of enzymes that play critical roles in regulation. The simplest and best-understood biochemically is the catalytic…”
Get more information

Oxygen Tension Regulates the Expression of Angiogenesis Factor by Macrophages by Knighton, David R., Hunt, Thomas K., Scheuenstuhl, Heinz, Halliday, Betty J., Werb, Zena, Banda, Michael J.

“…When cultured in a hypoxic environment similar to that found in the center of a wound, macrophages secreted active angiogenesis factor into the medium. Under…”
Get full text

Isolation of a Nonmitogenic Angiogenesis Factor from Wound Fluid by Banda, Michael J., Knighton, David R., Hunt, Thomas K., Werb, Zena

“…Angiogenesis, or new capillary growth, is essential to normal growth and wound healing. It is also active in several pathologic states, including the growth of…”
Get full text

Regulation of wound-healing angiogenesis-effect of oxygen gradients and inspired oxygen concentration by Knighton, D R, Silver, I A, Hunt, T K

“…Tissue hypoxia is a well-known stimulus to angiogenesis. The central dead space in healing wounds has been shown to be hypoxic (PO2 = 1 to 10). Angiogenesis is…”
Get more information

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex by Kissinger, Charles R, Parge, Hans E, Knighton, Daniel R, Lewis, Cristina T, Pelletier, Laura A, Tempczyk, Anna, Kalish, Vincent J, Tucker, Kathleen D, Showalter, Richard E, Moomaw, Ellen W, Gastinel, Louis N, Habuka, Noriyuki, Chen, Xinghai, Maldonado, Fausto, Barker, John E, Bacquet, Russell, Villafranca, J. Ernest

“…Calcineurin (CaN) is a calcium- and calmodulin-dependent protein serine/threonine phosphate which is critical for several important cellular processes,…”
Get full text

Alloxan diabetes alters the rabbit transarterial wall oxygen gradient by Santilli, Steven Michael, Fiegel, Vance David, Knighton, David Reed

“…Purpose: Atherosclerotic vascular occlusive disease is the most common complication of diabetes mellitus and accounts for 75% of deaths in diabetic patients…”
Get full text

Angiogenic activity in damaged skeletal muscle by Phillips, G D, Knighton, D R

“…After a muscle is damaged, blood vessels spontaneously grow into the injured region as the muscle fibers regenerate. The stimulus for this vascular ingrowth is…”
Get more information

An angiogenic extract from skeletal muscle stimulates monocyte and endothelial cell chemotaxis in vitro by Phillips, G D, Schilb, L A, Fiegel, V D, Knighton, D R

“…The purpose of this study was to determine whether the extraction of skeletal muscle with a combination of ethanol and hydrochloric acid yields a product…”
Get more information

Migration of myogenic cells in the rat extensor digitorum longus muscle studied with a split autograft model by PHILLIPS, G. D, HOFFMAN, J. R, KNIGHTON, D. R

“…The ability of myogenic cells to migrate perpendicular to the long axis of freely autografted muscles was examined. Rat extensor digitorum longus muscles were…”
Get full text

Amputation prevention in a high-risk population through comprehensive wound-healing protocol by Doucette, M M, Fylling, C, Knighton, D R

“…This study included patients who presented with at least one chronic nonhealing ulcer and had been told by their referring physician that they would require…”
Get more information