Search Results - "Knight, Tamara R."

Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity by Cover, Cathleen, Mansouri, Abdellah, Knight, Tamara R, Bajt, Mary Lynn, Lemasters, John J, Pessayre, Dominique, Jaeschke, Hartmut

“…Intracellular sources of peroxynitrite formation and potential targets for this powerful oxidant and nitrating agent have not been identified after…”
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Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione by Knight, Tamara R, Ho, Ye-Shih, Farhood, Anwar, Jaeschke, Hartmut

“…Acetaminophen (AAP) overdose causes formation of nitrotyrosine, a footprint of peroxynitrite, in centrilobular hepatocytes. The importance of peroxynitrite for…”
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Scavenging peroxynitrite with glutathione promotes regeneration and enhances survival during acetaminophen-induced liver injury in mice by Bajt, Mary Lynn, Knight, Tamara R, Farhood, Anwar, Jaeschke, Hartmut

“…Acetaminophen (AAP) overdose causes formation of peroxynitrite in centrilobular hepatocytes. Treatment with glutathione (GSH) after AAP accelerated recovery of…”
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Acetaminophen-Induced Inhibition of Fas Receptor-Mediated Liver Cell Apoptosis: Mitochondrial Dysfunction versus Glutathione Depletion by Knight, Tamara R., Jaeschke, Hartmut

“…We reported previously that acetaminophen overdose interrupts the signaling pathway of Fas receptor-mediated apoptosis. The aim of our study was to investigate…”
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Acetaminophen toxicity in mice lacking NADPH oxidase activity: role of peroxynitrite formation and mitochondrial oxidant stress by James, Laura P, McCullough, Sandra S, Knight, Tamara R, Jaeschke, Hartmut, Hinson, Jack A

“…Previous data have indicated that activated macrophages may play a role in the mediation of acetaminophen toxicity. In the present study, we examined the…”
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Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis by Aleksunes, Lauren M., Slitt, Angela L., Maher, Jonathan M., Dieter, Matthew Z., Knight, Tamara R., Goedken, Michael, Cherrington, Nathan J., Chan, Jefferson Y., Klaassen, Curtis D., Manautou, José E.

“…Bile duct ligation (BDL) causes hepatocellular oxidative stress and injury. The transcription factor nuclear factor-E2-related factor (Nrf2) induces expression…”
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Induction of Hepatic Glutathione S-Transferases in Male Mice by Prototypes of Various Classes of Microsomal Enzyme Inducers by Knight, Tamara R., Choudhuri, Supratim, Klaassen, Curtis D.

“…The underlying need for glutathione S-transferase (Gst) induction is thought to be an adaptive response to chemical stress within the cell. Classical…”
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The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity by Jaeschke, Hartmut, Knight, Tamara R., Bajt, Mary Lynn

“…Acetaminophen (AAP) overdose can cause severe hepatotoxicity and even liver failure in experimental animals and humans. Despite substantial efforts over the…”
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Genetic and Epigenetic Regulation and Expression Signatures of Glutathione S-Transferases in Developing Mouse Liver by Cui, Julia Yue, Choudhuri, Supratim, Knight, Tamara R., Klaassen, Curtis D.

“…The hepatic glutathione S-transferases (Gsts) are critical phase II enzymes in protecting cellular macromolecules against electrophiles and oxidative stress…”
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Acetaminophen-Induced Oxidant Stress and Cell Injury in Cultured Mouse Hepatocytes: Protection by N-Acetyl Cysteine by Bajt, Mary Lynn, Knight, Tamara R., Lemasters, John J., Jaeschke, Hartmut

“…The increase in cellular and mitochondrial glutathione disulfide (GSSG) levels and the GSSG:GSH ratio after acetaminophen (AAP) overdose suggest the…”
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Mode of Cell Death after Acetaminophen Overdose in Mice: Apoptosis or Oncotic Necrosis? by Gujral, Jaspreet S., Knight, Tamara R., Farhood, Anwar, Bajt, Mary Lynn, Jaeschke, Hartmut

“…Acetaminophen (AAP) overdose can cause severe liver injury and liver failure in experimental animals and humans. Recently, several authors proposed that…”
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Vascular and Hepatocellular Peroxynitrite Formation during Acetaminophen Toxicity: Role of Mitochondrial Oxidant Stress by Knight, Tamara R., Kurtz, Angela, Bajt, Mary Lynn, Hinson, Jack A., Jaeschke, Hartmut

“…Peroxynitrite may be involved in acetaminophen-induced liver damage. However, it is unclear if peroxynitrite is generated in hepatocytes or in the vasculature…”
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Role of Lipid Peroxidation as a Mechanism of Liver Injury after Acetaminophen Overdose in Mice by Knight, Tamara R., Fariss, Marc W., Farhood, Anwar, Jaeschke, Hartmut

“…Mitochondrial oxidant stress and peroxynitrite formation have been implicated in the pathophysiology of acetaminophen-induced (AAP-induced) liver injury…”
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Pathophysiological Role of Poly(ADP-Ribose) Polymerase (PARP) Activation during Acetaminophen-Induced Liver Cell Necrosis in Mice by Cover, Cathleen, Fickert, Peter, Knight, Tamara R., Fuchsbichler, Andrea, Farhood, Anwar, Trauner, Michael, Jaeschke, Hartmut

“…DNA fragmentation in hepatocytes occurs early after acetaminophen (AAP) overdose in mice. DNA strandbreaks can induce excessive activation of poly(ADP-ribose)…”
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Peroxynitrite formation and sinusoidal endothelial cell injury during acetaminophen-induced hepatotoxicity in mice by Knight, Tamara R, Jaeschke, Hartmut

“…INTRODUCTION: Vascular injury and accumulation of red blood cells in the space of Disse (hemorrhage) is a characteristic feature of acetaminophen…”
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