Search Results - "Knight, Spencer C."

Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection by East-Seletsky, Alexandra, O’Connell, Mitchell R., Knight, Spencer C., Burstein, David, Cate, Jamie H. D., Tjian, Robert, Doudna, Jennifer A.

“…The CRISPR-associated bacterial enzyme C2c2 is shown to contain two separable, distinct sites for the highly sensitive detection and cleavage of…”
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Genomes in Focus: Development and Applications of CRISPR‐Cas9 Imaging Technologies by Knight, Spencer C., Tjian, Robert, Doudna, Jennifer A.

“…The discovery of the CRISPR‐Cas9 endonuclease has enabled facile genome editing in living cells and organisms. Catalytically inactive Cas9 (dCas9) retains the…”
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Dynamics of CRISPR-Cas9 genome interrogation in living cells by Knight, Spencer C., Xie, Liangqi, Deng, Wulan, Guglielmi, Benjamin, Witkowsky, Lea B., Bosanac, Lana, Zhang, Elisa T., Beheiry, Mohamed El, Masson, Jean-Baptiste, Dahan, Maxime, Liu, Zhe, Doudna, Jennifer A., Tjian, Robert

“…The RNA-guided CRISPR-associated protein Cas9 is used for genome editing, transcriptional modulation, and live-cell imaging. Cas9-guide RNA complexes recognize…”
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Mechanistic Study of the Stereoselective Polymerization of d,l-Lactide Using Indium(III) Halides by Pietrangelo, Agostino, Knight, Spencer C., Gupta, Aalo K., Yao, Letitia J., Hillmyer, Marc A., Tolman, William B.

“…We report the results of a comprehensive investigation of the recently discovered stereoselective and controlled polymerization of racemic lactide (d,l-LA)…”
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Expanded COVID-19 phenotype definitions reveal distinct patterns of genetic association and protective effects by Roberts, Genevieve H. L., Partha, Raghavendran, Rhead, Brooke, Knight, Spencer C., Park, Danny S., Coignet, Marie V., Zhang, Miao, Berkowitz, Nathan, Turrisini, David A., Gaddis, Michael, McCurdy, Shannon R., Pavlovic, Milos, Ruiz, Luong, Sass, Chodon, Haug Baltzell, Asher K., Guturu, Harendra, Girshick, Ahna R., Ball, Catherine A., Hong, Eurie L., Rand, Kristin A.

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Expanded COVID-19 phenotype definitions reveal distinct patterns of genetic association and protective effects by Roberts, Genevieve H. L., Partha, Raghavendran, Rhead, Brooke, Knight, Spencer C., Park, Danny S., Coignet, Marie V., Zhang, Miao, Berkowitz, Nathan, Turrisini, David A., Gaddis, Michael, McCurdy, Shannon R., Pavlovic, Milos, Ruiz, Luong, Sass, Chodon, Haug Baltzell, Asher K., Guturu, Harendra, Girshick, Ahna R., Ball, Catherine A., Hong, Eurie L., Rand, Kristin A.

“…Multiple COVID-19 genome-wide association studies (GWASs) have identified reproducible genetic associations indicating that there is a genetic component to…”
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Genetic risk factors for COVID-19 and influenza are largely distinct by Kosmicki, Jack A., Marcketta, Anthony, Sharma, Deepika, Di Gioia, Silvio Alessandro, Batista, Samantha, Yang, Xiao-Man, Tzoneva, Gannie, Martinez, Hector, Sidore, Carlo, Kessler, Michael D., Horowitz, Julie E., Roberts, Genevieve H. L., Justice, Anne E., Banerjee, Nilanjana, Coignet, Marie V., Leader, Joseph B., Park, Danny S., Lanche, Rouel, Maxwell, Evan, Knight, Spencer C., Bai, Xiaodong, Guturu, Harendra, Baltzell, Asher, Girshick, Ahna R., McCurdy, Shannon R., Partha, Raghavendran, Mansfield, Adam J., Turissini, David A., Zhang, Miao, Mbatchou, Joelle, Watanabe, Kyoko, Verma, Anurag, Sirugo, Giorgio, Ritchie, Marylyn D., Salerno, William J., Shuldiner, Alan R., Rader, Daniel J., Mirshahi, Tooraj, Marchini, Jonathan, Overton, John D., Carey, David J., Habegger, Lukas, Reid, Jeffrey G., Economides, Aris, Kyratsous, Christos, Karalis, Katia, Baum, Alina, Cantor, Michael N., Rand, Kristin A., Hong, Eurie L., Ball, Catherine A., Siminovitch, Katherine, Baras, Aris, Abecasis, Goncalo R., Ferreira, Manuel A. R.

“…Coronavirus disease 2019 (COVID-19) and influenza are respiratory illnesses caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and…”
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COVID-19 susceptibility and severity risks in a cross-sectional survey of over 500 000 US adults by Knight, Spencer C, McCurdy, Shannon R, Rhead, Brooke, Coignet, Marie V, Park, Danny S, Roberts, Genevieve H L, Berkowitz, Nathan D, Zhang, Miao, Turissini, David, Delgado, Karen, Pavlovic, Milos, Haug Baltzell, Asher K, Guturu, Harendra, Rand, Kristin A, Girshick, Ahna R, Hong, Eurie L, Ball, Catherine A, Banda, Yambazi, Bi, Ke, Burton, Robert, Champine, Marjan, Curtis, Ross, Drokhlyansky, Abby, Elrick, Ashley, Foo, Cat, Gaddis, Michael, Gu, Jialiang, Hateley, Shannon, Harris, Heather, King, Shea, Maldonado, Christine, McCartney-Melstad, Evan, McFarland, Alexandra, Miller, Patty, Nguyen, Luong, Noto, Keith, Pei, Jingwen, Petersen, Jenna, Pew, Scott, Sass, Chodon, Schraiber, Josh, Sedghifar, Alisa, Smelter, Andrey, South, Sarah, Starr, Barry, Vaughn, Cecily, Wang, Yong

“…ObjectivesThe enormous toll of the COVID-19 pandemic has heightened the urgency of collecting and analysing population-scale datasets in real time to monitor…”
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Genome im Fokus: Entwicklung und Anwendungen von CRISPR‐Cas9‐Bildgebungstechnologien by Knight, Spencer C., Tjian, Robert, Doudna, Jennifer A.

“…Die Entdeckung der CRISPR‐Cas9‐Endonuklease ermöglicht die einfache Genom‐Editierung von lebenden Zellen und Organismen. Katalytisch deaktivierte Cas9 (dCas9)…”
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Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease by Horowitz, Julie E., Kosmicki, Jack A., Damask, Amy, Sharma, Deepika, Roberts, Genevieve H. L., Justice, Anne E., Banerjee, Nilanjana, Coignet, Marie V., Yadav, Ashish, Leader, Joseph B., Marcketta, Anthony, Park, Danny S., Lanche, Rouel, Maxwell, Evan, Knight, Spencer C., Bai, Xiaodong, Guturu, Harendra, Sun, Dylan, Baltzell, Asher, Kury, Fabricio S. P., Backman, Joshua D., Girshick, Ahna R., O’Dushlaine, Colm, McCurdy, Shannon R., Partha, Raghavendran, Mansfield, Adam J., Turissini, David A., Li, Alexander H., Zhang, Miao, Mbatchou, Joelle, Watanabe, Kyoko, Gurski, Lauren, McCarthy, Shane E., Kang, Hyun M., Dobbyn, Lee, Stahl, Eli, Verma, Anurag, Sirugo, Giorgio, Ritchie, Marylyn D., Jones, Marcus, Balasubramanian, Suganthi, Siminovitch, Katherine, Salerno, William J., Shuldiner, Alan R., Rader, Daniel J., Mirshahi, Tooraj, Locke, Adam E., Marchini, Jonathan, Overton, John D., Carey, David J., Habegger, Lukas, Cantor, Michael N., Rand, Kristin A., Hong, Eurie L., Reid, Jeffrey G., Ball, Catherine A., Baras, Aris, Abecasis, Gonçalo R., Ferreira, Manuel A. R.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters human host cells via angiotensin-converting enzyme 2 (ACE2) and causes coronavirus disease…”
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Genome im Fokus: Entwicklung und Anwendungen von CRISPR‐Cas9‐Bildgebungstechnologien by Knight, Spencer C., Tjian, Robert, Doudna, Jennifer A.

“…Abstract Die Entdeckung der CRISPR‐Cas9‐Endonuklease ermöglicht die einfache Genom‐Editierung von lebenden Zellen und Organismen. Katalytisch deaktivierte Cas9…”
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