Search Results - "Knight, Michael"

Obesity among African American people in the United States: A review by Lofton, Holly, Ard, Jamy D., Hunt, Rameck R., Knight, Michael G.

“…Obesity is a growing public health crisis in the United States and is associated with a substantial disease burden due to an increased risk for multiple…”
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Picometer Resolution Structure of the Coordination Sphere in the Metal-Binding Site in a Metalloprotein by NMR by Bertarello, Andrea, Benda, Ladislav, Sanders, Kevin J, Pell, Andrew J, Knight, Michael J, Pelmenschikov, Vladimir, Gonnelli, Leonardo, Felli, Isabella C, Kaupp, Martin, Emsley, Lyndon, Pierattelli, Roberta, Pintacuda, Guido

“…Most of our understanding of chemistry derives from atomic-level structures obtained with single-crystal X-ray diffraction. Metal centers in X-ray structures…”
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Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection by Kamel, Wael, Noerenberg, Marko, Cerikan, Berati, Chen, Honglin, Järvelin, Aino I., Kammoun, Mohamed, Lee, Jeffrey Y., Shuai, Ni, Garcia-Moreno, Manuel, Andrejeva, Anna, Deery, Michael J., Johnson, Natasha, Neufeldt, Christopher J., Cortese, Mirko, Knight, Michael L., Lilley, Kathryn S., Martinez, Javier, Davis, Ilan, Bartenschlager, Ralf, Mohammed, Shabaz, Castello, Alfredo

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). SARS-CoV-2 relies on cellular RNA-binding proteins…”
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Correlative multi-scale cryo-imaging unveils SARS-CoV-2 assembly and egress by Mendonça, Luiza, Howe, Andrew, Gilchrist, James B., Sheng, Yuewen, Sun, Dapeng, Knight, Michael L., Zanetti-Domingues, Laura C., Bateman, Benji, Krebs, Anna-Sophia, Chen, Long, Radecke, Julika, Li, Vivian D., Ni, Tao, Kounatidis, Ilias, Koronfel, Mohamed A., Szynkiewicz, Marta, Harkiolaki, Maria, Martin-Fernandez, Marisa L., James, William, Zhang, Peijun

“…Since the outbreak of the SARS-CoV-2 pandemic, there have been intense structural studies on purified viral components and inactivated viruses. However,…”
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Rotavirus RNA chaperone mediates global transcriptome-wide increase in RNA backbone flexibility by Coria, Aaztli, Wienecke, Anastacia, Knight, Michael L, Desirò, Daniel, Laederach, Alain, Borodavka, Alexander

“…Due to genome segmentation, rotaviruses must co-package eleven distinct genomic RNAs. The packaging is mediated by virus-encoded RNA chaperones, such as the…”
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Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 by Huo, Jiandong, Le Bas, Audrey, Ruza, Reinis R., Duyvesteyn, Helen M. E., Mikolajek, Halina, Malinauskas, Tomas, Tan, Tiong Kit, Rijal, Pramila, Dumoux, Maud, Ward, Philip N., Ren, Jingshan, Zhou, Daming, Harrison, Peter J., Weckener, Miriam, Clare, Daniel K., Vogirala, Vinod K., Radecke, Julika, Moynié, Lucile, Zhao, Yuguang, Gilbert-Jaramillo, Javier, Knight, Michael L., Tree, Julia A., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Carroll, Miles W., Carrique, Loic, Shah, Pranav N. M., James, William, Townsend, Alain R., Stuart, David I., Owens, Raymond J., Naismith, James H.

“…The SARS-CoV-2 virus is more transmissible than previous coronaviruses and causes a more serious illness than influenza. The SARS-CoV-2 receptor binding domain…”
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T2 Relaxometry and Diffusion Tensor Indices of the Hippocampus and Entorhinal Cortex Improve Sensitivity and Specificity of MRI to Detect Amnestic Mild Cognitive Impairment and Alzheimer's Disease Dementia by Knight, Michael J., Wearn, Alfie, Coulthard, Elizabeth, Kauppinen, Risto A.

“…Background Quantitative T2 and diffusion MRI indices inform about tissue state and microstructure, both of which may be affected by pathology before tissue…”
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The structure of the influenza A virus genome by Dadonaite, Bernadeta, Gilbertson, Brad, Knight, Michael L., Trifkovic, Sanja, Rockman, Steven, Laederach, Alain, Brown, Lorena E., Fodor, Ervin, Bauer, David L. V.

“…Influenza A viruses (IAVs) constitute a major threat to human health. The IAV genome consists of eight single-stranded viral RNA segments contained in separate…”
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Photoinduced cross-linking of formulation buffer amino acids to monoclonal antibodies by Powell, Thomas, Knight, Michael J., Wood, Amanda, O'Hara, John, Burkitt, William

“…[Display omitted] The correct choice of formulation buffer is a critical aspect of drug development and is chosen primarily to improve the stability of a…”
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The SARS-CoV-2 RNA polymerase is a viral RNA capping enzyme by Walker, Alexander P, Fan, Haitian, Keown, Jeremy R, Knight, Michael L, Grimes, Jonathan M, Fodor, Ervin

“…Abstract SARS-CoV-2 is a positive-sense RNA virus responsible for the Coronavirus Disease 2019 (COVID-19) pandemic, which continues to cause significant…”
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Computational modelling of diatom silicic acid transporters predicts a conserved fold with implications for their function and evolution by Knight, Michael J, Hardy, Benjamin J, Wheeler, Glen L, Curnow, Paul

“…Diatoms are an important group of algae that can produce intricate silicified cell walls (frustules). The complex process of silicification involves a set of…”
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Multimodal Response to Copper Binding in Superoxide Dismutase Dynamics by Bonaccorsi, Marta, Knight, Michael J, Le Marchand, Tanguy, Dannatt, Hugh R. W, Schubeis, Tobias, Salmon, Loïc, Felli, Isabella C, Emsley, Lyndon, Pierattelli, Roberta, Pintacuda, Guido

“…Copper/zinc superoxide dismutase (SOD) is a homodimeric metalloenzyme that has been extensively studied as a benchmark for structure–function relationships in…”
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Structure and backbone dynamics of a microcrystalline metalloprotein by solid-state NMR by Knight, Michael J., Pell, Andrew J., Bertini, Ivano, Felli, Isabella C., Gonnelli, Leonardo, Pierattelli, Roberta, Herrmann, Torsten, Emsley, Lyndon, Pintacuda, Guido

“…We introduce a new approach to improve structural and dynamical determination of large metalloproteins using solid-state nuclear magnetic resonance (NMR) with…”
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Direct evidence of the molecular basis for biological silicon transport by Knight, Michael J., Senior, Laura, Nancolas, Bethany, Ratcliffe, Sarah, Curnow, Paul

“…Diatoms are an important group of eukaryotic algae with a curious evolutionary innovation: they sheath themselves in a cell wall made largely of silica. The…”
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Magnetic Resonance Relaxation Anisotropy: Physical Principles and Uses in Microstructure Imaging by Knight, Michael J., Dillon, Serena, Jarutyte, Lina, Kauppinen, Risto A.

“…Magnetic resonance imaging (MRI) provides an excellent means of studying tissue microstructure noninvasively since the microscopic tissue environment is…”
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Discovery of a Photoinduced Histidine-Histidine Cross-Link in an IgG4 Antibody by Powell, Thomas, Knight, Michael J, O'Hara, John, Burkitt, William

“…A novel histidine-histidine (His-His) photooxidative cross-link has been identified in an IgG4 antibody. It was formed between the side chain of a histidine…”
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Detection of Isopeptide Bonds in Monoclonal Antibody Aggregates by Powell, Thomas, Knight, Michael J., Wood, Amanda, O’Hara, John, Burkitt, William

“…Purpose A major difficulty in monoclonal antibody (mAb) therapeutic development is product aggregation. In this study, intermolecular isopeptide bonds in mAb…”
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Rapid Proton-Detected NMR Assignment for Proteins with Fast Magic Angle Spinning by Barbet-Massin, Emeline, Pell, Andrew J, Retel, Joren S, Andreas, Loren B, Jaudzems, Kristaps, Franks, W. Trent, Nieuwkoop, Andrew J, Hiller, Matthias, Higman, Victoria, Guerry, Paul, Bertarello, Andrea, Knight, Michael J, Felletti, Michele, Le Marchand, Tanguy, Kotelovica, Svetlana, Akopjana, Inara, Tars, Kaspars, Stoppini, Monica, Bellotti, Vittorio, Bolognesi, Martino, Ricagno, Stefano, Chou, James J, Griffin, Robert G, Oschkinat, Hartmut, Lesage, Anne, Emsley, Lyndon, Herrmann, Torsten, Pintacuda, Guido

“…Using a set of six 1H-detected triple-resonance NMR experiments, we establish a method for sequence-specific backbone resonance assignment of magic angle…”
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Weight regulation in menopause by Knight, Michael G., Anekwe, Chika, Washington, Krystilyn, Akam, Eftitan Y., Wang, Emily, Stanford, Fatima Cody

“…Obesity is a chronic disease of epidemic proportions that continues to affect millions of Americans each year. Postmenopausal women are particularly affected…”
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Legal hunting for conservation of highly threatened species: The case of African rhinos by ’t Sas‐Rolfes, Michael, Emslie, Richard, Adcock, Keryn, Knight, Michael

“…Legal hunting of threatened species—and especially the recreational practice of “trophy hunting”—is controversial with ethical objections being increasingly…”
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