Search Results - "Knight, Julian C."

Major Histocompatibility Complex Genomics and Human Disease by Trowsdale, John, Knight, Julian C

“…Over several decades, various forms of genomic analysis of the human major histocompatibility complex (MHC) have been extremely successful in picking up many…”
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The association between endometriosis and autoimmune diseases: a systematic review and meta-analysis by Shigesi, Nina, Kvaskoff, Marina, Kirtley, Shona, Feng, Qian, Fang, Hai, Knight, Julian C, Missmer, Stacey A, Rahmioglu, Nilufer, Zondervan, Krina T, Becker, Christian M

“…Abstract BACKGROUND Endometriosis is a chronic gynaecological disorder that affects 2–10% of women of reproductive age. The aetiology of endometriosis is…”
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Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression by Fairfax, Benjamin P., Humburg, Peter, Makino, Seiko, Naranbhai, Vivek, Wong, Daniel, Lau, Evelyn, Jostins, Luke, Plant, Katharine, Andrews, Robert, McGee, Chris, Knight, Julian C.

“…To systematically investigate the impact of immune stimulation upon regulatory variant activity, we exposed primary monocytes from 432 healthy Europeans to…”
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XGR software for enhanced interpretation of genomic summary data, illustrated by application to immunological traits by Fang, Hai, Knezevic, Bogdan, Burnham, Katie L, Knight, Julian C

“…Biological interpretation of genomic summary data such as those resulting from genome-wide association studies (GWAS) and expression quantitative trait loci…”
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Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus by Downes, Damien J., Cross, Amy R., Hua, Peng, Roberts, Nigel, Schwessinger, Ron, Cutler, Antony J., Munis, Altar M., Brown, Jill, Mielczarek, Olga, de Andrea, Carlos E., Melero, Ignacio, Gill, Deborah R., Hyde, Stephen C., Knight, Julian C., Todd, John A., Sansom, Stephen N., Issa, Fadi, Davies, James O. J., Hughes, Jim R.

“…The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) disease (COVID-19) pandemic has caused millions of deaths worldwide. Genome-wide association…”
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Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study by Davenport, Emma E, DPhil, Burnham, Katie L, MGen, Radhakrishnan, Jayachandran, DPhil, Humburg, Peter, PhD, Hutton, Paula, PG Cert, Mills, Tara C, DPhil, Rautanen, Anna, PhD, Gordon, Anthony C, MD, Garrard, Christopher, DPhil, Hill, Adrian V S, Prof, Hinds, Charles J, Prof, Knight, Julian C, Prof

“…Summary Background Effective targeted therapy for sepsis requires an understanding of the heterogeneity in the individual host response to infection. We…”
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Systematic identification of trans eQTLs as putative drivers of known disease associations by Westra, Harm-Jan, Peters, Marjolein J, Esko, Tõnu, Yaghootkar, Hanieh, Schurmann, Claudia, Kettunen, Johannes, Christiansen, Mark W, Fairfax, Benjamin P, Schramm, Katharina, Powell, Joseph E, Zhernakova, Alexandra, Zhernakova, Daria V, Veldink, Jan H, Van den Berg, Leonard H, Karjalainen, Juha, Withoff, Sebo, Uitterlinden, André G, Hofman, Albert, Rivadeneira, Fernando, 't Hoen, Peter A C, Reinmaa, Eva, Fischer, Krista, Nelis, Mari, Milani, Lili, Melzer, David, Ferrucci, Luigi, Singleton, Andrew B, Hernandez, Dena G, Nalls, Michael A, Homuth, Georg, Nauck, Matthias, Radke, Dörte, Völker, Uwe, Perola, Markus, Salomaa, Veikko, Brody, Jennifer, Suchy-Dicey, Astrid, Gharib, Sina A, Enquobahrie, Daniel A, Lumley, Thomas, Montgomery, Grant W, Makino, Seiko, Prokisch, Holger, Herder, Christian, Roden, Michael, Grallert, Harald, Meitinger, Thomas, Strauch, Konstantin, Li, Yang, Jansen, Ritsert C, Visscher, Peter M, Knight, Julian C, Psaty, Bruce M, Ripatti, Samuli, Teumer, Alexander, Frayling, Timothy M, Metspalu, Andres, van Meurs, Joyce B J, Franke, Lude

“…Lude Franke and colleagues report the results of a large expression QTL study performed on peripheral blood samples from 5,311 individuals. They identify trans…”
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Distinct HLA associations of LGI1 and CASPR2-antibody diseases by Binks, Sophie, Varley, James, Lee, Wanseon, Makuch, Mateusz, Elliott, Katherine, Gelfand, Jeffrey M, Jacob, Saiju, Leite, M Isabel, Maddison, Paul, Chen, Mian, Geschwind, Michael D, Grant, Eleanor, Sen, Arjune, Waters, Patrick, McCormack, Mark, Cavalleri, Gianpiero L, Barnardo, Martin, Knight, Julian C, Irani, Sarosh R

“…The mechanisms responsible for the generation of LGI1- or CASPR2-antibodies are unknown. Binks et al. describe two strikingly dichotomous HLA-associations,…”
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Genetics of gene expression in immunity to infection by Fairfax, Benjamin P, Knight, Julian C

“…Highlights • Mapping gene expression as a quantitative trait resolves functional regulatory genetic variants. • Genomic modulators of immune gene expression…”
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Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB11501 is regulated by vitamin D by Ramagopalan, Sreeram V, Maugeri, Narelle J, Handunnetthi, Lahiru, Lincoln, Matthew R, Orton, Sarah-Michelle, Dyment, David A, Deluca, Gabriele C, Herrera, Blanca M, Chao, Michael J, Sadovnick, A Dessa, Ebers, George C, Knight, Julian C

“…Multiple sclerosis (MS) is a complex trait in which allelic variation in the MHC class II region exerts the single strongest effect on genetic risk…”
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Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells by Kasela, Silva, Kisand, Kai, Tserel, Liina, Kaleviste, Epp, Remm, Anu, Fischer, Krista, Esko, Tõnu, Westra, Harm-Jan, Fairfax, Benjamin P, Makino, Seiko, Knight, Julian C, Franke, Lude, Metspalu, Andres, Peterson, Pärt, Milani, Lili

“…Inappropriate activation or inadequate regulation of CD4+ and CD8+ T cells may contribute to the initiation and progression of multiple autoimmune and…”
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Enhanced understanding of the host–pathogen interaction in sepsis: new opportunities for omic approaches by Goh, Cyndi, FFICM, Knight, Julian C, Prof

“…Summary Progress in sepsis research has been severely hampered by a heterogeneous disease phenotype, limiting the interpretation of clinical trials and the…”
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Genome-wide CRISPR/Cas9-knockout in human induced Pluripotent Stem Cell (iPSC)-derived macrophages by Navarro-Guerrero, Elena, Tay, Chwen, Whalley, Justin P., Cowley, Sally A., Davies, Ben, Knight, Julian C., Ebner, Daniel

“…Genome engineering using CRISPR/Cas9 technology enables simple, efficient and precise genomic modifications in human cells. Conventional immortalized cell…”
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Mapping the epigenomic landscape of human monocytes following innate immune activation reveals context-specific mechanisms driving endotoxin tolerance by Amarasinghe, Harindra E, Zhang, Ping, Whalley, Justin P, Allcock, Alice, Migliorini, Gabriele, Brown, Andrew C, Scozzafava, Giuseppe, Knight, Julian C

“…Abstract Background Monocytes are key mediators of innate immunity to infection, undergoing profound and dynamic changes in epigenetic state and immune…”
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HLA-C Level Is Regulated by a Polymorphic Oct1 Binding Site in the HLA-C Promoter Region by Vince, Nicolas, Li, Hongchuan, Ramsuran, Veron, Naranbhai, Vivek, Duh, Fuh-Mei, Fairfax, Benjamin P., Saleh, Bahara, Knight, Julian C., Anderson, Stephen K., Carrington, Mary

“…Differential HLA-C levels influence several human diseases, but the mechanisms responsible are incompletely characterized. Using a validated prediction…”
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Epigenomic analysis reveals a dynamic and context-specific macrophage enhancer landscape associated with innate immune activation and tolerance by Zhang, Ping, Amarasinghe, Harindra E., Whalley, Justin P., Tay, Chwen, Fang, Hai, Migliorini, Gabriele, Brown, Andrew C., Allcock, Alice, Scozzafava, Giuseppe, Rath, Phalguni, Davies, Benjamin, Knight, Julian C.

“…Abstract Background Chromatin states and enhancers associate gene expression, cell identity and disease. Here, we systematically delineate the acute innate…”
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Regulatory polymorphisms underlying complex disease traits by KNIGHT, Julian C

“…There is growing evidence that genetic variation plays an important role in the determination of individual susceptibility to complex disease traits. In…”
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Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele by Al-Mossawi, Hussein, Yager, Nicole, Taylor, Chelsea A., Lau, Evelyn, Danielli, Sara, de Wit, Jelle, Gilchrist, James, Nassiri, Isar, Mahe, Elise A., Lee, Wanseon, Rizvi, Laila, Makino, Seiko, Cheeseman, Jane, Neville, Matt, Knight, Julian C., Bowness, Paul, Fairfax, Benjamin P.

“…IL-7 is a key factor in T cell immunity and common variants at IL7R , encoding its receptor, are associated with autoimmune disease susceptibility. IL7R mRNA…”
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Using de novo assembly to identify structural variation of eight complex immune system gene regions by Zhang, Jia-Yuan, Roberts, Hannah, Flores, David S. C, Cutler, Antony J, Brown, Andrew C, Whalley, Justin P, Mielczarek, Olga, Buck, David, Lockstone, Helen, Xella, Barbara, Oliver, Karen, Corton, Craig, Betteridge, Emma, Bashford-Rogers, Rachael, Knight, Julian C, Todd, John A, Band, Gavin

“…Driven by the necessity to survive environmental pathogens, the human immune system has evolved exceptional diversity and plasticity, to which several factors…”
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Cell Specific eQTL Analysis without Sorting Cells by Westra, Harm-Jan, Arends, Danny, Esko, Tõnu, Peters, Marjolein J, Schurmann, Claudia, Schramm, Katharina, Kettunen, Johannes, Yaghootkar, Hanieh, Fairfax, Benjamin P, Andiappan, Anand Kumar, Li, Yang, Fu, Jingyuan, Karjalainen, Juha, Platteel, Mathieu, Visschedijk, Marijn, Weersma, Rinse K, Kasela, Silva, Milani, Lili, Tserel, Liina, Peterson, Pärt, Reinmaa, Eva, Hofman, Albert, Uitterlinden, André G, Rivadeneira, Fernando, Homuth, Georg, Petersmann, Astrid, Lorbeer, Roberto, Prokisch, Holger, Meitinger, Thomas, Herder, Christian, Roden, Michael, Grallert, Harald, Ripatti, Samuli, Perola, Markus, Wood, Andrew R, Melzer, David, Ferrucci, Luigi, Singleton, Andrew B, Hernandez, Dena G, Knight, Julian C, Melchiotti, Rossella, Lee, Bernett, Poidinger, Michael, Zolezzi, Francesca, Larbi, Anis, Wang, De Yun, van den Berg, Leonard H, Veldink, Jan H, Rotzschke, Olaf, Makino, Seiko, Salomaa, Veikko, Strauch, Konstantin, Völker, Uwe, van Meurs, Joyce B J, Metspalu, Andres, Wijmenga, Cisca, Jansen, Ritsert C, Franke, Lude

“…The functional consequences of trait associated SNPs are often investigated using expression quantitative trait locus (eQTL) mapping. While trait-associated…”
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