Search Results - "Knight, Helen M."

Dysregulation of RNA modification systems in clinical populations with neurocognitive disorders by Knight, Helen M, Demirbugen Öz, Merve, PerezGrovas-Saltijeral, Adriana

“…The study of modified RNA known as epitranscriptomics has become increasingly relevant in our understanding of disease-modifying mechanisms. Methylation of N6…”
Get full text

A Cytogenetic Abnormality and Rare Coding Variants Identify ABCA13 as a Candidate Gene in Schizophrenia, Bipolar Disorder, and Depression by Knight, Helen M., Pickard, Benjamin S., Maclean, Alan, Malloy, Mary P., Soares, Dinesh C., McRae, Allan F., Condie, Alison, White, Angela, Hawkins, William, McGhee, Kevin, van Beck, Margaret, MacIntyre, Donald J., Starr, John M., Deary, Ian J., Visscher, Peter M., Porteous, David J., Cannon, Ronald E., St Clair, David, Muir, Walter J., Blackwood, Douglas H.R.

“…Schizophrenia and bipolar disorder are leading causes of morbidity across all populations, with heritability estimates of ∼80% indicating a substantial genetic…”
Get full text

Damaging coding variants within kainate receptor channel genes are enriched in individuals with schizophrenia, autism and intellectual disabilities by Koromina, Maria, Flitton, Miles, Blockley, Alix, Mellor, Ian R., Knight, Helen M.

“…Schizophrenia (Scz), autism spectrum disorder (ASD) and intellectual disability are common complex neurodevelopmental disorders. Kainate receptors (KARs) are…”
Get full text

The importance of m 6 A topology in chicken embryo mRNA: a precise mapping of m 6 A at the conserved chicken β-actin zipcode by Baron, Francis, Zhang, Mi, Archer, Nathan, Bellows, Eleanor, Knight, Helen M, Welham, Simon, Rutland, Catrin S, Mongan, Nigel P, Hayes, Christopher J, Fray, Rupert G, Bodi, Zsuzsa

“…-methyladenosine (m A) in mRNA regulates almost every stage in the mRNA life cycle, and the development of methodologies for the high-throughput detection of…”
Get full text

The importance of m6A topology in chicken embryo mRNA: a precise mapping of m6A at the conserved chicken β-actin zipcode by Baron, Francis, Zhang, Mi, Archer, Nathan, Bellows, Eleanor, Knight, Helen M, Welham, Simon, Rutland, Catrin S, Mongan, Nigel P, Hayes, Christopher J, Fray, Rupert G, Bodi, Zsuzsa

“…N6-methyladenosine (m6A) in mRNA regulates almost every stage in the mRNA life cycle, and the development of methodologies for the high-throughput detection of…”
Get full text

The expanding role of cap-adjacent modifications in animals by Eleanor Bellows, Eleanor Bellows, Rupert G. Fray, Helen M. Knight, Nathan Archer

“…Eukaryotic mRNA cap structures directly influence mRNA stability, translation, and immune recognition. While the significance of the mRNA cap itself has been…”
Get full text

Vitamin intake is associated with improved visuospatial and verbal semantic memory in middle-aged individuals by Flitton, Miles, Macdonald, Ian A., Knight, Helen M.

“…Objectives: Factors maintaining cognitive health are still largely unknown. In particular, the cognitive benefits associated with vitamin intake and vitamin…”
Get full text

Cognitive endophenotypes in a family with bipolar disorder with a risk locus on chromosome 4 by Drysdale, Emma, Knight, Helen M, McIntosh, Andrew M, Blackwood, Douglas HR

“…Objectives:  We studied cognitive function in high‐risk relatives belonging to a single extended family showing linkage of bipolar disorder to a locus on…”
Get full text

GRIK4/KA1 protein expression in human brain and correlation with bipolar disorder risk variant status by Knight, Helen M., Walker, Robert, James, Rachel, Porteous, David J., Muir, Walter J., Blackwood, Douglas H.R., Pickard, Benjamin S.

“…The kainate class of ionotropic glutamate receptors is involved in the regulation of neuronal transmission and synaptic plasticity. Previously we reported that…”
Get full text

Homozygosity mapping in a family presenting with schizophrenia, epilepsy and hearing impairment by KNIGHT, Helen M, MACLEAN, Alan, IRFAN, Muhammad, NAEEM, Farooq, CASS, Stephen, PICKARD, Benjamin S, MUIR, Walter J, BLACKWOOD, Douglas H. R, AYUB, Muhammad

“…Homozygosity mapping within consanguineous families is a powerful method of localising genes for autosomal recessive disease. We investigated a family from…”
Get full text

A Genome-Wide Association Study implicates the APOE locus in non-pathological cognitive ageing by Davies, Gail, Harris, Sarah E, Reynolds, Chandra A, Payton, Antony, Knight, Helen M, Liewald, David C, Lopez, Lorna M, Luciano, Michelle, Gow, Alan J, Corley, Janie, Henderson, Ross, Murray, Catherine, Pattie, Alison, Fox, Helen C., Redmond, Paul, Lutz, Michael W, Chiba-Falek, Ornit, Linnertz, Colton, Saith, Sunita, Haggarty, Paul, McNeill, Geraldine, Ke, Xiayi, Ollier, William, Horan, Michael, Roses, Allen D, Ponting, Chris P, Porteous, David J, Tenesa, Albert, Pickles, Andrew, Starr, John M, Whalley, Lawrence J, Pedersen, Nancy L, Pendleton, Neil, Visscher, Peter M, Deary, Ian J

“…Cognitive decline is a feared aspect of growing old. It is a major contributor to lower quality of life and loss of independence in old age. We investigated…”
Get full text

A Cytogenetic Abnormality and Rare Coding Variants Identify ABCA 13 as a Candidate Gene in Schizophrenia, Bipolar Disorder, and Depression by KNIGHT, Helen M, PICKARD, Benjamin S, VAN BECK, Margaret, MACINTYRE, Donald J, STARR, John M, DEARY, Ian J, VISSCHER, Peter M, PORTEOUS, David J, CANNON, Ronald E, CLAIR, David St, MUIR, Walter J, BLACKWOOD, Douglas H. R, MACLEAN, Alan, MALLOY, Mary P, SOARES, Dinesh C, MCRAE, Allan F, CONDIE, Alison, WHITE, Angela, HAWKINS, William, MCGHEE, Kevin

Get full text