Search Results - "Knight, Gwenan"

Antimicrobial resistance and COVID-19: Intersections and implications by Knight, Gwenan M, Glover, Rebecca E, McQuaid, C Finn, Olaru, Ioana D, Gallandat, Karin, Leclerc, Quentin J, Fuller, Naomi M, Willcocks, Sam J, Hasan, Rumina, van Kleef, Esther, Chandler, Clare Ir

“…Before the coronavirus 2019 (COVID-19) pandemic began, antimicrobial resistance (AMR) was among the top priorities for global public health. Already a complex…”
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COVID-19 length of hospital stay: a systematic review and data synthesis by Rees, Eleanor M, Nightingale, Emily S, Jafari, Yalda, Waterlow, Naomi R, Clifford, Samuel, B Pearson, Carl A, Group, Cmmid Working, Jombart, Thibaut, Procter, Simon R, Knight, Gwenan M

“…The COVID-19 pandemic has placed an unprecedented strain on health systems, with rapidly increasing demand for healthcare in hospitals and intensive care units…”
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The health and cost burden of antibiotic resistant and susceptible Escherichia coli bacteraemia in the English hospital setting: A national retrospective cohort study by Naylor, Nichola R, Pouwels, Koen B, Hope, Russell, Green, Nathan, Henderson, Katherine L, Knight, Gwenan M, Atun, Rifat, Robotham, Julie V, Deeny, Sarah R

“…Antibiotic resistance poses a threat to public health and healthcare systems. Escherichia coli causes more bacteraemia episodes in England than any other…”
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What settings have been linked to SARS-CoV-2 transmission clusters? by Leclerc, Quentin J., Fuller, Naomi M., Knight, Lisa E., Funk, Sebastian, Knight, Gwenan M.

“…Background : Concern about the health impact of novel coronavirus SARS-CoV-2 has resulted in widespread enforced reductions in people’s movement (“lockdowns”)…”
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Estimating the burden of antimicrobial resistance: a systematic literature review by Naylor, Nichola R, Atun, Rifat, Zhu, Nina, Kulasabanathan, Kavian, Silva, Sachin, Chatterjee, Anuja, Knight, Gwenan M, Robotham, Julie V

“…Accurate estimates of the burden of antimicrobial resistance (AMR) are needed to establish the magnitude of this global threat in terms of both health and…”
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Global burden of latent multidrug-resistant tuberculosis: trends and estimates based on mathematical modelling by Knight, Gwenan M, McQuaid, C Finn, Dodd, Peter J, Houben, Rein M G J

“…To end the global tuberculosis epidemic, latent tuberculosis infection needs to be addressed. All standard treatments for latent tuberculosis contain drugs to…”
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Modelling the synergistic effect of bacteriophage and antibiotics on bacteria: Killers and drivers of resistance evolution by Leclerc, Quentin J, Lindsay, Jodi A, Knight, Gwenan M

“…Bacteriophage (phage) are bacterial predators that can also spread antimicrobial resistance (AMR) genes between bacteria by generalised transduction. Phage are…”
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The transmission of Mycobacterium tuberculosis in high burden settings by Yates, Tom A, Dr, Khan, Palwasha Y, MBBCh, Knight, Gwenan M, PhD, Taylor, Jonathon G, PhD, McHugh, Timothy D, Prof, Lipman, Marc, MD, White, Richard G, PhD, Cohen, Ted, MD, Cobelens, Frank G, Prof, Wood, Robin, Prof, Moore, David A J, Prof, Abubakar, Ibrahim, Prof

“…Summary Unacceptable levels of Mycobacterium tuberculosis transmission are noted in high burden settings and a renewed focus on reducing person-to-person…”
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Modelling the implementation of narrow versus broader spectrum antibiotics in the empiric treatment of E. coli bacteraemia by Khurana, Mark P., Curran-Sebastian, Jacob, Bhatt, Samir, Knight, Gwenan M.

“…The implementation of new antimicrobial resistance stewardship programs is crucial in optimizing antibiotic use. However, prescription choices can be difficult…”
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Mathematical models of drug-resistant tuberculosis lack bacterial heterogeneity: A systematic review by Fuller, Naomi M, McQuaid, Christopher F, Harker, Martin J, Weerasuriya, Chathika K, McHugh, Timothy D, Knight, Gwenan M

“…Drug-resistant tuberculosis (DR-TB) threatens progress in the control of TB. Mathematical models are increasingly being used to guide public health decisions…”
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Mathematical modelling to study the horizontal transfer of antimicrobial resistance genes in bacteria: current state of the field and recommendations by Leclerc, Quentin J, Lindsay, Jodi A, Knight, Gwenan M

“…Antimicrobial resistance (AMR) is one of the greatest public health challenges we are currently facing. To develop effective interventions against this, it is…”
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Impact and cost-effectiveness of new tuberculosis vaccines in low- and middle-income countries by Knight, Gwenan M., Griffiths, Ulla, Sumner, Tom, Laurence, Yoko V., Gheorghe, Adrian, Vassall, Anna, Glaziou, Philippe, White, Richard G.

“…Significance To aid in prioritizing the development of tuberculosis (TB) vaccines most likely to reach the 2050 TB elimination goal, we estimated the impact…”
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Potential impact of tuberculosis vaccines in China, South Africa, and India by Harris, Rebecca C, Sumner, Tom, Knight, Gwenan M, Zhang, Hui, White, Richard G

“…More effective tuberculosis vaccines are needed to help reach World Health Organization tuberculosis elimination goals. Insufficient evidence exists on the…”
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Routine childhood immunisation during the COVID-19 pandemic in Africa: a benefit–risk analysis of health benefits versus excess risk of SARS-CoV-2 infection by Abbas, Kaja, Procter, Simon R, van Zandvoort, Kevin, Clark, Andrew, Funk, Sebastian, Mengistu, Tewodaj, Hogan, Dan, Dansereau, Emily, Jit, Mark, Flasche, Stefan, Houben, Rein M G J, Edmunds, W John, Villabona-Arenas, Christian Julian, Atkins, Katherine E, Knight, Gwenan M, Sun, Fiona Yueqian, Auzenbergs, Megan, Rosello, Alicia, Klepac, Petra, Hellewell, Joel, Russell, Timothy W, Tully, Damien C, Emery, Jon C, Gibbs, Hamish P, Munday, James D, Quilty, Billy J, Diamond, Charlie, Pearson, Carl A B, Leclerc, Quentin J, Nightingale, Emily S, Liu, Yang, Endo, Akira, Deol, Arminder K, Kucharski, Adam J, Abbott, Sam, Jarvis, Christopher I, O'Reilly, Kathleen, Jombart, Thibaut, Gimma, Amy, Bosse, Nikos I, Prem, Kiesha, Hué, Stéphane, Davies, Nicholas G, Eggo, Rosalind M, Clifford, Samuel, Medley, Graham

“…National immunisation programmes globally are at risk of suspension due to the severe health system constraints and physical distancing measures in place to…”
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Potential impact of influenza vaccine roll-out on antibiotic use in Africa by Knight, Gwenan M, Clarkson, Madeleine, de Silva, Thushan I

“…Influenza infections result in both inappropriate and appropriate antibiotic prescribing. There is a huge burden of both influenza and infections caused by…”
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Definition of a genetic relatedness cutoff to exclude recent transmission of meticillin-resistant Staphylococcus aureus: a genomic epidemiology analysis by Coll, Francesc, Raven, Kathy E, Knight, Gwenan M, Blane, Beth, Harrison, Ewan M, Leek, Danielle, Enoch, David A, Brown, Nicholas M, Parkhill, Julian, Peacock, Sharon J

“…Whole-genome sequencing (WGS) can be used in genomic epidemiology investigations to confirm or refute outbreaks of bacterial pathogens, and to support targeted…”
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The effectiveness of biosecurity interventions in reducing the transmission of bacteria from livestock to humans at the farm level: A systematic literature review by Youssef, Dina Mohamed, Wieland, Barbara, Knight, Gwenan M., Lines, Jo, Naylor, Nichola R.

“…Zoonotic bacterial infections are a health hazard for people who are in regular contact with livestock at the farm level. Improved biosecurity can limit…”
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Systematic review of mathematical models exploring the epidemiological impact of future TB vaccines by Harris, Rebecca C., Sumner, Tom, Knight, Gwenan M., White, Richard G.

“…Mathematical models are useful for assessing the potential epidemiological impact of future tuberculosis (TB) vaccines. We conducted a systematic review of…”
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Quantifying patient- and hospital-level antimicrobial resistance dynamics in Staphylococcus aureus from routinely collected data by Leclerc, Quentin, Clements, Alastair, Dunn, Helen, Hatcher, James, Lindsay, Jodi A, Grandjean, Louis, Knight, Gwenan M

“…Antimicrobial resistance (AMR) to all antibiotic classes has been found in the pathogen . The reported prevalence of these resistances varies, driven by…”
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Global burden of disease due to rifampicin-resistant tuberculosis: a mathematical modeling analysis by Menzies, Nicolas A., Allwood, Brian W., Dean, Anna S., Dodd, Pete J., Houben, Rein M. G. J., James, Lyndon P., Knight, Gwenan M., Meghji, Jamilah, Nguyen, Linh N., Rachow, Andrea, Schumacher, Samuel G., Mirzayev, Fuad, Cohen, Ted

“…In 2020, almost half a million individuals developed rifampicin-resistant tuberculosis (RR-TB). We estimated the global burden of RR-TB over the lifetime of…”
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