Search Results - "Knight, Daniel R"
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Diversity and Evolution in the Genome of Clostridium difficile
Published in Clinical microbiology reviews (01-07-2015)“…Clostridium difficile infection (CDI) is the leading cause of antimicrobial and health care-associated diarrhea in humans, presenting a significant burden to…”
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Whole‐genome sequencing links Clostridium (Clostridioides) difficile in a single hospital to diverse environmental sources in the community
Published in Journal of applied microbiology (01-09-2022)“…Aims To investigate if Clostridium (Clostridioides) difficile infection (CDI), traditionally thought of as hospital‐acquired, can be genomically linked to…”
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Genomic Delineation of Zoonotic Origins of Clostridium difficile
Published in Frontiers in public health (20-06-2019)“…is toxin-producing antimicrobial resistant (AMR) enteropathogen historically associated with diarrhea and pseudomembranous colitis in hospitalized patients. In…”
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Major genetic discontinuity and novel toxigenic species in Clostridioides difficile taxonomy
Published in eLife (11-06-2021)“…Clostridioides difficile infection (CDI) remains an urgent global One Health threat. The genetic heterogeneity seen across C. difficile underscores its wide…”
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Removal of mobile genetic elements from the genome of Clostridioides difficile and the implications for the organism's biology
Published in Frontiers in microbiology (20-06-2024)“…is an emerging pathogen of One Health significance. Its highly variable genome contains mobile genetic elements (MGEs) such as transposons and prophages that…”
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Cross-Sectional Study Reveals High Prevalence of Clostridium difficile Non-PCR Ribotype 078 Strains in Australian Veal Calves at Slaughter
Published in Applied and Environmental Microbiology (01-04-2013)“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Prevalence of Gastrointestinal Clostridium difficile Carriage in Australian Sheep and Lambs
Published in Applied and Environmental Microbiology (01-09-2013)“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Towards integrated cross-sectoral surveillance of pathogens and antimicrobial resistance: Needs, approaches, and considerations for linking surveillance to action
Published in Environment international (01-10-2024)“…Pathogenic and antimicrobial-resistant (AMR) microorganisms are continually transmitted between human, animal, and environmental reservoirs, contributing to…”
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Clostridium difficile ribotype 017 - characterization, evolution and epidemiology of the dominant strain in Asia
Published in Emerging microbes & infections (01-01-2019)“…Clostridium difficile ribotype (RT) 017 is an important toxigenic C. difficile RT which, due to a deletion in the repetitive region of the tcdA gene, only…”
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Laboratory detection of Clostridium difficile in piglets in Australia
Published in Journal of clinical microbiology (01-11-2014)“…Clostridium difficile is a well-known enteric pathogen of humans and the causative agent of high-morbidity enteritis in piglets aged 1 to 7 days. C. difficile…”
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Significant Differences Characterise the Correlation Coefficients between Biocide and Antibiotic Susceptibility Profiles in Staphylococcus aureus
Published in Current pharmaceutical design (01-01-2015)“…There is a growing concern by regulatory authorities for the selection of antibiotic resistance caused by the use of biocidal products. We aimed to complete…”
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Spectrum of antibacterial activity and mode of action of a novel tris-stilbene bacteriostatic compound
Published in Scientific reports (02-05-2018)“…The spectrum of activity and mode of action of a novel antibacterial agent, 135C , was investigated using a range of microbiological and genomic approaches…”
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Prevalence of binary toxin positive Clostridium difficile in diarrhoeal humans in the absence of epidemic ribotype 027
Published in PloS one (08-11-2017)“…Virulence of Clostridium difficile is primarily attributed to the large clostridial toxins A and B while the role of binary toxin (CDT) remains unclear. The…”
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Correlating Quantitative and Genomic SARS-CoV-2 Wastewater Data with Clinical Metrics in Metropolitan Perth, Western Australia
Published in Environments (Basel, Switzerland) (01-04-2024)“…Wastewater-based epidemiology (WBE) has emerged as a key method for the continuous monitoring of COVID-19 prevalence including circulating SARS-CoV-2 lineages…”
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Antimicrobial susceptibility of Clostridium difficile isolated in Thailand
Published in Antimicrobial resistance & infection control (08-06-2017)“…Exposure to antimicrobials is the major risk factor associated with infection (CDI). Paradoxically, treatment of CDI with antimicrobials remains the preferred…”
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Complete Genome Sequences of Evolutionary Clade C-III Strains of Clostridioides ( Clostridium ) difficile Isolated from the Environment in Western Australia
Published in Microbiology resource announcements (17-05-2023)“…Clostridioides (Clostridium) difficile in the environment is thought to contribute to C. difficile infection in community settings. Here, we provide complete…”
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Genomic Analysis of Clostridioides difficile Recovered from Horses in Western Australia
Published in Microorganisms (Basel) (03-07-2023)“…poses an ongoing threat as a cause of gastrointestinal disease in humans and animals. Traditionally considered a human healthcare-related disease, increases in…”
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Development of 1,2,4-Oxadiazole Antimicrobial Agents to Treat Enteric Pathogens within the Gastrointestinal Tract
Published in ACS omega (01-03-2022)“…Colonization of the gastrointestinal (GI) tract with pathogenic bacteria is an important risk factor for the development of certain potentially severe and…”
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Cationic Peptidomimetic Amphiphiles Having a N-Aryl- or N-Naphthyl-1,2,3-Triazole Core Structure Targeting Clostridioides (Clostridium) difficile: Synthesis, Antibacterial Evaluation, and an In Vivo C. difficile Infection Model
Published in Antibiotics (Basel) (26-07-2021)“…Clostridioides (also known as Clostridium) difficile is a Gram-positive anaerobic, spore producing bacterial pathogen that causes severe gastrointestinal…”
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One Health: the global challenge of Clostridium difficile infection
Published in Microbiology Australia (01-03-2020)“…The One Health concept recognises that the health of humans is interconnected to the health of animals and the environment. It encourages multidisciplinary…”
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