Search Results - "Knight, D R"

ProHits-viz: a suite of web tools for visualizing interaction proteomics data by Knight, James D R, Choi, Hyungwon, Gupta, Gagan D, Pelletier, Laurence, Raught, Brian, Nesvizhskii, Alexey I, Gingras, Anne-Claude

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Long-term follow-up on overall survival from the MM-009 and MM-010 phase III trials of lenalidomide plus dexamethasone in patients with relapsed or refractory multiple myeloma by Dimopoulos, M A, Chen, C, Spencer, A, Niesvizky, R, Attal, M, Stadtmauer, E A, Petrucci, M T, Yu, Z, Olesnyckyj, M, Zeldis, J B, Knight, R D, Weber, D M

“…We present a pooled update of two large, multicenter MM-009 and MM-010 placebo-controlled randomized phase III trials that included 704 patients and assessed…”
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Natural products show diverse mechanisms of action against Clostridium difficile by Roshan, N., Riley, T.V., Knight, D.R., Steer, J.H., Hammer, K.A.

“…Aims To investigate the mechanisms of action of natural products with bactericidal (cinnamon root powder, peppermint oil, trans‐cinnamaldehyde, menthol and…”
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Phase I Study of an Immunomodulatory Thalidomide Analog, CC-4047, in Relapsed or Refractory Multiple Myeloma by SCHEY, S. A, FIELDS, P, BARTLETT, J. B, CLARKE, I. A, ASHAN, G, KNIGHT, R. D, STREETLY, M, DALGLEISH, A. G

“…To assess the safety, efficacy, and immunomodulatory effects of CC-4047 (Actimid; Celgene, San Diego, CA) in patients with relapsed or refractory myeloma…”
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The GATOR–Rag GTPase pathway inhibits mTORC1 activation by lysosome-derived amino acids by Hesketh, Geoffrey G., Papazotos, Fotini, Pawling, Judy, Rajendran, Dushyandi, Knight, James D. R., Martinez, Sebastien, Taipale, Mikko, Schramek, Daniel, Dennis, James W., Gingras, Anne-Claude

“…Intricacies of amino acid sensing The way in which cells sense amino acids derived from external proteins taken up by micropinocytosis and then degraded in the…”
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A web-tool for visualizing quantitative protein-protein interaction data by Knight, James D. R., Liu, Guomin, Zhang, Jian Ping, Pasculescu, Adrian, Choi, Hyungwon, Gingras, Anne-Claude

“…Quantitative interaction proteomics data can be a challenge to efficiently analyze and subsequently present to an audience in a simple and easy to understand…”
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Clostridium difficile infection diagnosis in a paediatric population: comparison of methodologies by Hart, J., Putsathit, P., Knight, D. R., Sammels, L., Riley, T. V., Keil, A.

“…The increasing incidence of Clostridium difficile infection (CDI) in paediatric hospitalised populations, combined with the emergence of hypervirulent strains,…”
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Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions by Couzens, Amber L, Knight, James D R, Kean, Michelle J, Teo, Guoci, Weiss, Alexander, Dunham, Wade H, Lin, Zhen-Yuan, Bagshaw, Richard D, Sicheri, Frank, Pawson, Tony, Wrana, Jeffrey L, Choi, Hyungwon, Gingras, Anne-Claude

“…The Hippo pathway regulates organ size and tissue homeostasis in response to multiple stimuli, including cell density and mechanotransduction. Pharmacological…”
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Conservation, variability and the modeling of active protein kinases by Knight, James D R, Qian, Bin, Baker, David, Kothary, Rashmi

“…The human proteome is rich with protein kinases, and this richness has made the kinase of crucial importance in initiating and maintaining cell behavior…”
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Clostridium difficile and One Health by Lim, S.C., Knight, D.R., Riley, T.V.

“…For over four decades, Clostridium difficile has been a significant enteric pathogen of humans. It is associated with the use of antimicrobials that generally…”
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Muscle O2 uptake kinetics in humans: implications for metabolic control by Grassi, B, Poole, D C, Richardson, R S, Knight, D R, Erickson, B K, Wagner, P D

“…Muscle O2 uptake (VO2) kinetics in response to an augmented energetic requirement (on-transition) has never been directly determined in humans. We have…”
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Pamidronate prevents skeletal complications and is effective palliative treatment in women with breast carcinoma and osteolytic bone metastases long term follow-up of two randomized, placebo-controlled trials by LIPTON, A, THERIAULT, R. L, HORTOBAGYI, G. N, SIMEONE, J, KNIGHT, R. D, MELLARS, K, REITSMA, D. J, HEFFERNAN, M, SEAMAN, J. J

“…Pamidronate therapy previously has been shown to reduce skeletal complications effectively for up to 12 months in breast carcinoma patients with bone…”
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Toxicity profile of the immunomodulatory thalidomide analogue, lenalidomide: Phase I clinical trial of three dosing schedules in patients with solid malignancies by Sharma, R.A., Steward, W.P., Daines, C.A., Knight, R.D., O’Byrne, K.J., Dalgleish, A.G.

“…Thalidomide is an anti-angiogenic agent currently used to treat patients with malignant cachexia or multiple myeloma. Lenalidomide (CC-5013) is an…”
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The role of conserved water molecules in the catalytic domain of protein kinases by Knight, James D. R., Hamelberg, Donald, McCammon, J. Andrew, Kothary, Rashmi

“…Protein kinases are essential signaling molecules with a characteristic bilobal shape that has been studied for over 15 years. Despite the number of crystal…”
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Efficacy of Pamidronate in Reducing Skeletal Complications in Patients with Breast Cancer and Lytic Bone Metastases by Hortobagyi, Gabriel N, Theriault, Richard L, Porter, Lester, Blayney, Douglas, Lipton, Allan, Sinoff, Clive, Wheeler, Helen, Simeone, Joseph F, Seaman, John, Knight, Robert D, Heffernan, Maika, Reitsma, Dirk J, Kennedy, Ian, Allan, Simon G, Mellars, Kathleen

“…Bone metastases occur in most women with advanced breast cancer. The destruction of bone in these lesions results from osteoclast-induced bone resorption that…”
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MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway by Couzens, Amber L., Xiong, Shawn, Knight, James D.R., Mao, Daniel Y., Guettler, Sebastian, Picaud, Sarah, Kurinov, Igor, Filippakopoulos, Panagis, Sicheri, Frank, Gingras, Anne-Claude

“…The Hippo tumor suppressor pathway regulates organ size and tissue homoeostasis in response to diverse signaling inputs. The core of the pathway consists of a…”
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Wave and place fixed DPOAE maps of the human ear by Knight, R D, Kemp, D T

“…Human intermodulation distortion product otoacoustic emissions (DPOAE) can be a mixture of low and high latency components. They have different level, phase,…”
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SAINTq: Scoring protein-protein interactions in affinity purification - mass spectrometry experiments with fragment or peptide intensity data by Teo, Guoci, Koh, Hiromi, Fermin, Damian, Lambert, Jean-Philippe, Knight, James D.R., Gingras, Anne-Claude, Choi, Hyungwon

“…SAINT (Significance Analysis of INTeractome) is a probabilistic method for scoring bait‐prey interactions against negative controls in affinity purification –…”
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Contamination of Australian newborn calf carcasses at slaughter with Clostridium difficile by Knight, D.R., Putsathit, P., Elliott, B., Riley, T.V.

“…In North America and Europe, reports of a genetic overlap between toxigenic strains of Clostridium difficile isolated from humans, livestock and retail meat…”
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Extended survival and reduced risk of AML progression in erythroid-responsive lenalidomide-treated patients with lower-risk del(5q) MDS by List, A F, Bennett, J M, Sekeres, M A, Skikne, B, Fu, T, Shammo, J M, Nimer, S D, Knight, R D, Giagounidis, A

“…Lenalidomide is the approved treatment for patients with red blood cell (RBC) transfusion-dependent lower-risk myelodysplastic syndromes (MDS) and chromosome…”
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