Search Results - "Knepper, M"

Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery by Zhou, H., Yuen, P.S.T., Pisitkun, T., Gonzales, P.A., Yasuda, H., Dear, J.W., Gross, P., Knepper, M.A., Star, R.A.

“…Urinary exosomes containing apical membrane and intracellular fluid are normally secreted into the urine from all nephron segments, and may carry protein…”
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Exosomal Fetuin-A identified by proteomics: A novel urinary biomarker for detecting acute kidney injury by Zhou, H., Pisitkun, T., Aponte, A., Yuen, P.S.T., Hoffert, J.D., Yasuda, H., Hu, X., Chawla, L., Shen, R.-F., Knepper, M.A., Star, R.A.

“…Urinary exosomes containing apical membrane and intracellular fluid are normally secreted into the urine from all nephron segments, and may carry protein…”
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Molecular physiology of urinary concentrating mechanism: regulation of aquaporin water channels by vasopressin by Knepper, M A

“…The purpose of this review is to illustrate the application of molecular methodologies to the investigation of a fundamentally integrative problem in renal…”
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Exosomes in urine: Who would have thought…? by Knepper, M.A., Pisitkun, T.

“…Normal urine contains thousands of proteins, largely due to the presence of ‘exosomes,’ tiny vesicles secreted into the urine by renal epithelial cells. These…”
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A Mobile Phone Text Messaging Intervention to Manage Fatigue for People With Multiple Sclerosis, Spinal Cord Injury, and Stroke: Development and Usability Testing by Morgan, Kerri A, Wong, Alex W K, Walker, Kim, Desai, Rachel Heeb, Knepper, Tina M, Newland, Pamela K

“…Fatigue significantly affects daily functioning in persons with disabilities. Fatigue management can be challenging, and the information provided during…”
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Long-term regulation of four renal aquaporins in rats by Terris, J, Ecelbarger, C A, Nielsen, S, Knepper, M A

“…The aquaporins are molecular water channels expressed in the kidney and other organs. To investigate long-term regulation of renal expression of these water…”
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Aquaporin-3 water channel localization and regulation in rat kidney by Ecelbarger, C A, Terris, J, Frindt, G, Echevarria, M, Marples, D, Nielsen, S, Knepper, M A

“…The aquaporins are a family of water channels expressed in several water-transporting tissues, including the kidney. We have used a peptide-derived,…”
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Distribution of aquaporin-4 water channel expression within rat kidney by Terris, J, Ecelbarger, C A, Marples, D, Knepper, M A, Nielsen, S

“…The aquaporins are a family of transmembrane proteins that function as molecular water channels. Recently, a mercurial-insensitive water channel [MIWC or…”
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Redistribution of aquaporin-2 water channels induced by vasopressin in rat kidney inner medullary collecting duct by Marples, D, Knepper, M A, Christensen, E I, Nielsen, S

“…Aquaporin-2 (AQP2) is the predominant vasopressin-regulated water channel of the renal collecting duct. We tested whether vasopressin induces translocation of…”
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UT-A2: a 55-kDa urea transporter in thin descending limb whose abundance is regulated by vasopressin by Wade, J B, Lee, A J, Liu, J, Ecelbarger, C A, Mitchell, C, Bradford, A D, Terris, J, Kim, G H, Knepper, M A

“…The renal urea transporter gene (UT-A) produces different transcripts in the inner medullary collecting ducts (UT-A1) and thin descending limbs of Henle's loop…”
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Cellular and Subcellular Immunolocalization of Vasopressin-Regulated Water Channel in Rat Kidney by Nielsen, Soren, DiGiovanni, Susan R., Christensen, Erik Ilso, Knepper, Mark A., Harris, H. William

“…Vasopressin (antidiuretic hormone) regulates body water balance by controlling water permeability of the renal collecting ducts. The control mechanisms may…”
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The Aquaporin Family of Molecular Water Channels by Knepper, Mark A.

“…The aquaporins (AQPs) are a family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of cells of many…”
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Vasopressin Increases Water Permeability of Kidney Collecting Duct by Inducing Translocation of Aquaporin-CD Water Channels to Plasma Membrane by Nielsen, Soren, Chou, Chung-Lin, Marples, David, Christensen, Erik I., Kishore, Bellamkonda K., Knepper, Mark A.

“…Water excretion by the kidney is regulated by the peptide hormone vasopressin. Vasopressin increases the water permeability of the renal collecting duct cells,…”
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Dysregulation of renal sodium transporters in gentamicin-treated rats by Sassen, M.C., Kim, S.W., Kwon, T.-H., Knepper, M.A., Miller, R.T., Frøkiær, J., Nielsen, S.

“…We aimed to investigate the molecular mechanisms underlying the renal wasting of Na+, K+, Ca2+, and Mg2+ in gentamicin (GM)-treated rats. Male Wistar rats were…”
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Localization and regulation of the rat renal Na(+)-K(+)-2Cl- cotransporter, BSC-1 by Ecelbarger, C A, Terris, J, Hoyer, J R, Nielsen, S, Wade, J B, Knepper, M A

“…To investigate the role of the thick ascending limb (TAL) Na(+)-K(+)-2Cl- cotransporter in regulation of water excretion, we have prepared a peptide-derived…”
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Long-term regulation of proximal tubule acid–base transporter abundance by angiotensin II by Turban, S., Beutler, K.T., Morris, R.G., Masilamani, S., Fenton, R.A., Knepper, M.A., Packer, R.K.

“…In the proximal tubule, angiotensin II (Ang-II) regulates HCO−3 reabsorption and H+ secretion by binding the type 1 Ang-II (AT1) receptor, stimulating…”
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Bilateral ureteral obstruction downregulates expression of vasopressin-sensitive AQP-2 water channel in rat kidney by Frøkiaer, J, Marples, D, Knepper, M A, Nielsen, S

“…Polyuria after release of bilateral ureteral obstruction (BUO) is frequently seen in patients with urological disorders. In this study, we examined the effect…”
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Aldosterone-mediated regulation of ENaC alpha, beta, and gamma subunit proteins in rat kidney by Masilamani, S, Kim, G H, Mitchell, C, Wade, J B, Knepper, M A

“…Aldosterone stimulates sodium transport in the renal collecting duct by activating the epithelial sodium channel (ENaC). To investigate the basis of this…”
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Hypokalemia-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla and cortex by Marples, D, Frøkiaer, J, Dørup, J, Knepper, M A, Nielsen, S

“…Prolonged hypokalemia causes vasopressin-resistant polyuria. We have recently shown that another cause of severe polyuria, chronic lithium therapy, is…”
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CHIP28 Water Channels Are Localized in Constitutively Water-Permeable Segments of the Nephron by Nielsen, Søren, Smith, Barbara L., Christensen, Erik Ilsø, Knepper, Mark A., Agre, Peter

“…The sites of water transport along the nephron are well characterized, but the molecular basis of renal water transport remains poorly understood. CHIP28 is a…”
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