Search Results - "Knepel, W"

Inhibition of MafA transcriptional activity and human insulin gene transcription by interleukin-1β and mitogen-activated protein kinase kinase kinase in pancreatic islet beta cells by Oetjen, E, Blume, R, Cierny, I, Schlag, C, Kutschenko, A, Krätzner, R, Stein, R, Knepel, W

“…Aims/hypothesis Inappropriate insulin secretion and biosynthesis are hallmarks of beta cell dysfunction and contribute to the progression from a prediabetic…”
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Loss of insulin-induced inhibition of glucagon gene transcription in hamster pancreatic islet alpha cells by long-term insulin exposure by González, M, Böer, U, Dickel, C, Quentin, T, Cierny, I, Oetjen, E, Knepel, W

“…Aims/hypothesis Diabetes mellitus type 2 is characterised by hyperglucagonaemia, resulting in hepatic glucose production and hyperglycaemia. Considering that…”
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Inhibition of membrane depolarisation-induced transcriptional activity of cyclic AMP response element binding protein (CREB) by the dual-leucine-zipper-bearing kinase in a pancreatic islet beta cell line by Oetjen, E, Lechleiter, A, Blume, R, Nihalani, D, Holzman, L, Knepel, W

“…Aims/hypothesis The activation of the transcription factor cyclic AMP response element binding protein (CREB) by protein kinase A is inhibited by the human…”
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Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene transcription by Schwaninger, M, Schöfl, C, Blume, R, Rössig, L, Knepel, W

“…Clinical observations agree that antidepressant drugs are effective only after a lag phase of 1-3 weeks. This delay could be explained at the molecular level…”
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Membrane depolarization and calcium influx induce glucagon gene transcription in pancreatic islet cells through the cyclic AMP-responsive element by SCHWANINGER, M, GUNDULA LUX, BLUME, G, OETIJEN, E, HIDAKA, H, KNEPEL, W

“…Glucagon-producing pancreatic islet cells generate calcium-dependent action potentials. By the control of calcium influx through voltage-gated calcium…”
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Involvement of the Ca-dependent Phosphatase Calcineurin in Gene Transcription That Is Stimulated by cAMP through cAMP Response Elements by Schwaninger, M, Blume, R, Krüger, M, Lux, G, Oetjen, E, Knepel, W

“…Gene transcription can be induced by cAMP and Ca through distinct protein kinases phosphorylating the transcription factor CREB, which binds to cAMP response…”
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Distinct properties of the cAMP-responsive element of the rat insulin I gene by Oetjen, E, Diedrich, T, Eggers, A, Eckert, B, Knepel, W

“…The cAMP response element (CRE)-binding transcription factor CREB can mediate induction of gene transcription in response to calcium as well as to cAMP. Since…”
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Transcriptional activation of the rat glucagon gene by the cyclic AMP-responsive element in pancreatic islet cells by KNEPEL, W, CHAFITZ, J, HABENER, J. F

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Transcriptional control of pancreatic islet hormones gene expression by Knepel, W

“…Initiation of transcription requires transcription factors that recognize specific DNA sequences present in promoters and enhancers of the respective genes…”
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Alpha-cell-specific expression of the glucagon gene is conferred to the glucagon promoter element by the interactions of DNA-binding proteins by PHILIPPE, J, DRUCKER, D. J, KNEPEL, W, JEPEAL, L, MISULOVIN, Z, HABENER, J. F

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Inhibition of cAMP-responsive element-mediated gene transcription by cyclosporin A and FK506 after membrane depolarization by Schwaninger, M, Blume, R, Oetjen, E, Lux, G, Knepel, W

“…The cAMP-responsive element (CRE) and its cognate transcription factor CREB can mediate induction of gene transcription in response to membrane depolarization…”
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Inhibition of CREB- and cAMP response element-mediated gene transcription by the immunosuppressive drugs cyclosporin A and FK506 in T cells by Krüger, M, Schwaninger, M, Blume, R, Oetjen, E, Knepel, W

“…The clinically important immunosuppressant drugs cyclosporin A and FK506 (tacrolimus) inhibit in T-cells calcineurin phosphatase activity and nuclear…”
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Characterization of a novel protein kinase C response element in the glucagon gene by Fürstenau, U, Schwaninger, M, Blume, R, Kennerknecht, I, Knepel, W

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A pancreatic islet cell-specific enhancer-like element in the glucagon gene contains two domains binding distinct cellular proteins by KNEPEL, W, JEPEAL, L, HABENER, J. F

“…Interactions of nuclear proteins with cis-control elements are involved in the programmed developmental expression of the islet polypeptide hormone genes…”
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Nuclear protein binding and functional activity of a variant insulin gene found in non-insulin-dependent diabetes mellitus by Yildiz, N, Diedrich, T, Knepel, W

“…In a subset of patients with non-insulin-dependent diabetes mellitus an 8-base pair (bp) repeat was found from -322 to -315 in the 5'-flanking region of the…”
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GRF elevates cytosolic free calcium concentration in rat anterior pituitary cells by Schöfl, C, Sandow, J, Knepel, W

“…The effect of human growth hormone-releasing factor (GRF) on intracellular free calcium concentration ([Ca2+]i) was examined in rat anterior pituitary cells…”
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The effect of naloxone on vasopressin release from rat neurohypophysis incubated in vitro by Knepel, W, Meyer, D K

“…Rat posterior pituitaries were superfused in vitro and stimulated electrically. The concentrations of vasopressin in the superfusion medium were determined by…”
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Transcriptional Activity of Domain A of the Rat Glucagon G3 Element Conferred by an Islet-Specific Nuclear Protein That Also Binds to Similar Pancreatic Islet Cell-Specific Enhancer Sequences (PISCES) by WREGE, ANTJE, DIEDRICH, THOMAS, HOCHHUTH, CHRISTA, KNEPEL, WILLHART

“…A pancreatic islet cell-specific enhancer element in the rat glucagon gene, Glu-G3, contains two domains, one of which, domain A, has been shown to be…”
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Evidence for inhibition by beta-endorphin of vasopressin release during foot shock-induced stress in the rat by Knepel, W, Nutto, D, Hertting, G

“…This study was to ascertain the effect of naloxone and dexamethasone on vasopressin and beta-endorphin release in the rat during inescapable electric foot…”
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Effect of prostaglandin E2 on ACTH and β-endorphin release from rat adenohypophysis in vitro after secretagogues which can mimic various first or second messengers by KNEPEL, W, GÖTZ, D

“…The purpose of the present study was to further characterize the inhibition by prostaglandin E2 (PGE2) of adrenocorticotropin (ACTH) and beta-endorphin release…”
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