Search Results - "Kneen, Clare O"

Oxadiazolone bioisosteres of pregabalin and gabapentin by Wustrow, David J., Belliotti, Thomas R., Capiris, Thomas, Kneen, Clare O., Bryans, Justin S., Field, Mark J., Williams, Dic, El-Kattan, Ayman, Buchholz, Lisa, Kinsora, Jack J., Lotarski, Susan M., Vartanian, Mark G., Taylor, Charles P., Donevan, Sean D., Thorpe, Andrew J., Schwarz, Jacob B.

“…A series of oxadiazolone bioisosteres of pregabalin 1 and gabapentin 2 were prepared, and several were found to exhibit similar potency for the α 2-δ subunit…”
Get full text

Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors by Street, Leslie J, Baker, Raymond, Book, Tracey, Kneen, Clare O, MacLeod, Angus M, Merchant, Kevin J, Showell, Graham A, Saunders, John, Herbert, Richard H

“…The synthesis and biochemical evaluation of novel 1,2,4-oxadiazole-based muscarinic agonists which can readily penetrate into the CNS is reported. Efficacy and…”
Get full text

Carboxylate bioisosteres of gabapentin by Burgos-Lepley, Carmen E., Thompson, Lisa R., Kneen, Clare O., Osborne, Simon A., Bryans, Justin S., Capiris, Thomas, Suman-Chauhan, Nirmala, Dooley, David J., Donovan, Cindy M., Field, Mark J., Vartanian, Mark G., Kinsora, Jack J., Lotarski, Susan M., El-Kattan, Ayman, Walters, Karen, Cherukury, Madhu, Taylor, Charles P., Wustrow, David J., Schwarz, Jacob B.

“…Ring expansion and acid replacement with tetrazole furnished a compound with a similar pattern of activity to gabapentin. A series of carboxylate bioisosteres…”
Get full text

Identification of Novel Ligands for the Gabapentin Binding Site on the α2δ Subunit of a Calcium Channel and Their Evaluation as Anticonvulsant Agents by Bryans, Justin S, Davies, Natasha, Gee, Nicolas S, Dissanayake, Visaka U. K, Ratcliffe, Giles S, Horwell, David C, Kneen, Clare O, Morrell, Andrew I, Oles, Ryszard J, O'Toole, John C, Perkins, Gemma M, Singh, Lakhbir, Suman-Chauhan, Nirmala, O'Neill, Jacqueline A

“…As part of a program to investigate the structure−activity relationships of Gabapentin (Neurontin), a number of alkylated analogues were synthesized and…”
Get full text

Tetrahydropyridyloxadiazoles: semi-rigid muscarinic ligands by Showell, Graham A, Gibbons, Tracey L, Kneen, Clare O, MacLeod, Angus M, Merchant, Kevin, Saunders, John, Freedman, Stephen B, Patel, Shailendra, Baker, Raymond

Get full text

Carboxylate bioisosteres of gabapentin Dedicated to David W. Robertson in memory of his outstanding contributions as a mentor and drug hunter by Burgos-Lepley, Carmen E, Thompson, Lisa R, Kneen, Clare O, Osborne, Simon A, Bryans, Justin S, Capiris, Thomas, Suman-Chauhan, Nirmala, Dooley, David J, Donovan, Cindy M, Field, Mark J, Vartanian, Mark G, Kinsora, Jack J, Lotarski, Susan M, El-Kattan, Ayman, Walters, Karen, Cherukury, Madhu, Taylor, Charles P, Wustrow, David J, Schwarz, Jacob B

“…A series of carboxylate bioisosteres of structures related to gabapentin 1 have been prepared. When the carboxylate was replaced by a tetrazole, this group was…”
Get full text

Tetrahydropyridyloxadiazoles : semirigid muscarinic ligands by SHOWELL, G. A, GIBBONS, T. L, KNEEN, C. O, MACLEOD, A. M, MERCHANT, K, SAUNDERS, J, FREEDMAN, S. B, PATEL, S, BAKER, R

“…Recent studies have described novel azabicycle-based muscarinic agonists which readily penetrate into the central nervous system and are capable of displaying…”
Get full text

Investigation into the preferred conformation of gabapentin for interaction with its binding site on the α2δ subunit of a calcium channel by Bryans, Justin S., Davies, Natasha, Gee, Nicolas S., Horwell, David C., Kneen, Clare O., Morrell, Andrew I., O'Neill, Jacqueline A., Ratcliffe, Giles S.

“…A series of conformationally restricted Gabapentin analogues has been synthesised and used to propose the preferred conformation of Gabapentin for it to bind…”
Get full text

Identification of Novel Ligands for the Gabapentin Binding Site on the α 2 δ Subunit of a Calcium Channel and Their Evaluation as Anticonvulsant Agents by Bryans, Justin S., Davies, Natasha, Gee, Nicolas S., Dissanayake, Visaka U. K., Ratcliffe, Giles S., Horwell, David C., Kneen, Clare O., Morrell, Andrew I., Oles, Ryszard J., O'Toole, John C., Perkins, Gemma M., Singh, Lakhbir, Suman-Chauhan, Nirmala, O'Neill, Jacqueline A.

Get full text

Purification of the 5-hydroxytryptamine 5-HT3 receptor from NCB20 cells by McKernan, R M, Gillard, N P, Quirk, K, Kneen, C O, Stevenson, G I, Swain, C J, Ragan, C I

“…A 5-hydroxytryptamine 5-HT3 receptor binding site has been purified from deoxycholate-solubilized NCB20 cell membranes. Purification (1,700-fold) was achieved…”
Get full text

Inotropic 'A' ring substituted sulmazole and isomazole analogs by Barraclough, Paul, Black, James W, Cambridge, David, Collard, David, Firmin, David, Gerskowitch, V. Paul, Glen, Robert C, Giles, Heather, Hill, Alan P

“…A series of "A" ring substituted sulmazole and isomazole analogues have been prepared and evaluated as inotropic agents. pKA's, protonation sites, and log P…”
Get full text

Inotropic activities of imidazopyridines by Barraclough, P, Black, J W, Cambridge, D, Gerskowitch, V P, Hull, R A, Lyer, R, King, W R, Kneen, C O, Nobbs, M S, Shah, G P

“…A series of 2-substituted 1H-imidazo[4,5-b]pyridines and the isomeric 1H-imidazo[4,5-c]pyridine derivatives has been prepared and evaluated as inotropic…”
Get more information