Search Results - "Knaus, Petra"

Role of bone morphogenetic proteins in sprouting angiogenesis: differential BMP receptor‐dependent signaling pathways balance stalk vs. tip cell competence by Benn, Andreas, Hiepen, Christian, Osterland, Marc, Schütte, Christof, Zwijsen, An, Knaus, Petra

“…Before the onset of sprouting angiogenesis, the endothelium is prepatterned for the positioning of tip and stalk cells. Both cell identities are not static, as…”
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YAP-Mediated Mechanotransduction in Skeletal Muscle by Fischer, Martina, Rikeit, Paul, Knaus, Petra, Coirault, Catherine

“…Skeletal muscle is not only translating chemical energy into mechanical work, it is also a highly adaptive and regenerative tissue whose architecture and…”
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BMPR2 inhibits activin and BMP signaling via wild-type ALK2 by Olsen, Oddrun Elise, Sankar, Meenu, Elsaadi, Samah, Hella, Hanne, Buene, Glenn, Darvekar, Sagar Ramesh, Misund, Kristine, Katagiri, Takenobu, Knaus, Petra, Holien, Toril

“…TGF-β/BMP superfamily ligands require heteromeric complexes of type 1 and 2 receptors for ligand-dependent downstream signaling. Activin A, a TGF-β superfamily…”
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VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling by Benn, Andreas, Bredow, Clara, Casanova, Isabel, Vukičević, Slobodan, Knaus, Petra

“…Several vascular disorders, such as aberrant angiogenesis, atherosclerosis and pulmonary hypertension, have been linked to dysfunctional BMP signaling…”
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BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics by Hiepen, Christian, Jatzlau, Jerome, Hildebrandt, Susanne, Kampfrath, Branka, Goktas, Melis, Murgai, Arunima, Cuellar Camacho, Jose Luis, Haag, Rainer, Ruppert, Clemens, Sengle, Gerhard, Cavalcanti-Adam, Elisabetta Ada, Blank, Kerstin G, Knaus, Petra

“…Balanced transforming growth factor-beta (TGFβ)/bone morphogenetic protein (BMP)-signaling is essential for tissue formation and homeostasis. While gain in…”
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Load‐induced osteogenic differentiation of mesenchymal stromal cells is caused by mechano‐regulated autocrine signaling by Schreivogel, Sophie, Kuchibhotla, Virinchi, Knaus, Petra, Duda, Georg N., Petersen, Ansgar

“…Mechanical boundary conditions critically influence the bone healing process. In this context, previous in vitro studies have demonstrated that cyclic…”
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BMP Stimulation Differentially Affects Phosphorylation and Protein Stability of β-Catenin in Breast Cancer Cell Lines by Ilhan, Mustafa, Hastar, Nurcan, Kampfrath, Branka, Spierling, Deniz Neslihan, Jatzlau, Jerome, Knaus, Petra

“…Increased expression and nuclear translocation of β-CATENIN is frequently observed in breast cancer, and it correlates with poor prognosis. Current treatment…”
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Cell‐specific responses to the cytokine TGFβ are determined by variability in protein levels by Strasen, Jette, Sarma, Uddipan, Jentsch, Marcel, Bohn, Stefan, Sheng, Caibin, Horbelt, Daniel, Knaus, Petra, Legewie, Stefan, Loewer, Alexander

“…The cytokine TGFβ provides important information during embryonic development, adult tissue homeostasis, and regeneration. Alterations in the cellular response…”
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Antagonistic Activities of Vegfr3/Flt4 and Notch1b Fine-tune Mechanosensitive Signaling during Zebrafish Cardiac Valvulogenesis by Fontana, Federica, Haack, Timm, Reichenbach, Maria, Knaus, Petra, Puceat, Michel, Abdelilah-Seyfried, Salim

“…The formation of cardiac valves depends on mechanical forces exerted by blood flow. Endocardial cells lining the interior of the heart are sensitive to these…”
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Characterization of Fibrodysplasia Ossificans Progessiva relevant Acvr1/Acvr2 Activin receptors in medaka (Oryzias latipes) by Trumpp, Michael, Tan, Wen Hui, Burdzinski, Wiktor, Basler, Yara, Jatzlau, Jerome, Knaus, Petra, Winkler, Christoph

“…Activin and Bone Morphogenetic Protein (BMP) signaling plays crucial roles in vertebrate organ formation, including osteo- and angiogenesis, and tissue…”
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External mechanical loading overrules cell-cell mechanical communication in sprouting angiogenesis during early bone regeneration by Dazzi, Chiara, Mehl, Julia, Benamar, Mounir, Gerhardt, Holger, Knaus, Petra, Duda, Georg N, Checa, Sara

“…Sprouting angiogenesis plays a key role during bone regeneration. For example, insufficient early revascularization of the injured site can lead to delayed or…”
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Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva by Chaikuad, Apirat, Alfano, Ivan, Kerr, Georgina, Sanvitale, Caroline E., Boergermann, Jan H., Triffitt, James T., von Delft, Frank, Knapp, Stefan, Knaus, Petra, Bullock, Alex N.

“…Bone morphogenetic protein (BMP) receptor kinases are tightly regulated to control development and tissue homeostasis. Mutant receptor kinase domains escape…”
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Functional regulation of YAP mechanosensitive transcriptional coactivator by Focused Low-Intensity Pulsed Ultrasound (FLIPUS) enhances proliferation of murine mesenchymal precursors by Puts, Regina, Rikeit, Paul, Ruschke, Karen, Knaus, Petra, Schreivogel, Sophie, Raum, Kay

“…Yes-associated protein (YAP) acts as a mechanotransducer in determining the cell fate of murine C2C12 mesenchymal precursors as investigated after stimulation…”
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It Takes Two to Tango: Endothelial TGFβ/BMP Signaling Crosstalk with Mechanobiology by Hiepen, Christian, Mendez, Paul-Lennard, Knaus, Petra

“…Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-beta (TGFβ) superfamily of cytokines. While some ligand members are potent…”
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BMP10 as a potent inducer of trophoblast differentiation in human embryonic and induced pluripotent stem cells by Lichtner, Björn, Knaus, Petra, Lehrach, Hans, Adjaye, James

“…Abstract Bone morphogenetic proteins (BMPs) are known to induce diverse differentiation fates in human embryonic stem cells (hESCs). In the present study, we…”
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Nanoscale Control of Surface Immobilized BMP-2: Toward a Quantitative Assessment of BMP-Mediated Signaling Events by Schwab, Elisabeth H, Pohl, Theresa L. M, Haraszti, Tamás, Schwaerzer, Gerburg K, Hiepen, Christian, Spatz, Joachim P, Knaus, Petra, Cavalcanti-Adam, Elisabetta A

“…In this work we determine the impact of surface density of immobilized BMP-2 on intracellular signal transduction. We use block copolymer micellar…”
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Cofilin-1 phosphorylation catalyzed by ERK1/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by lamin A/C gene mutation by Chatzifrangkeskou, Maria, Yadin, David, Marais, Thibaut, Chardonnet, Solenne, Cohen-Tannoudji, Mathilde, Mougenot, Nathalie, Schmitt, Alain, Crasto, Silvia, Di Pasquale, Elisa, Macquart, Coline, Tanguy, Yannick, Jebeniani, Imen, Pucéat, Michel, Morales Rodriguez, Blanca, Goldmann, Wolfgang H, Dal Ferro, Matteo, Biferi, Maria-Grazia, Knaus, Petra, Bonne, Gisèle, Worman, Howard J, Muchir, Antoine

“…Abstract Hyper-activation of extracellular signal-regulated kinase (ERK) 1/2 contributes to heart dysfunction in cardiomyopathy caused by mutations in the…”
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BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway by Kopf, Jessica, Petersen, Ansgar, Duda, Georg N, Knaus, Petra

“…Efficient osteogenic differentiation is highly dependent on coordinated signals arising from growth factor signalling and mechanical forces. Bone morphogenetic…”
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Atheroprone fluid shear stress-regulated ALK1-Endoglin-SMAD signaling originates from early endosomes by Mendez, Paul-Lennard, Obendorf, Leon, Jatzlau, Jerome, Burdzinski, Wiktor, Reichenbach, Maria, Nageswaran, Vanasa, Haghikia, Arash, Stangl, Verena, Hiepen, Christian, Knaus, Petra

“…Fluid shear stress enhances endothelial SMAD1/5 signaling via the BMP9-bound ALK1 receptor complex supported by the co-receptor Endoglin. While moderate…”
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MiR‐497∼195 Cluster MicroRNAs Regulate Osteoblast Differentiation by Targeting BMP Signaling by Grünhagen, Johannes, Bhushan, Raghu, Degenkolbe, Elisa, Jäger, Marten, Knaus, Petra, Mundlos, Stefan, Robinson, Peter N, Ott, Claus‐Eric

“…ABSTRACT MicroRNAs play important roles during cell reprogramming and differentiation. In this study, we identified the miR‐497∼195 cluster, a member of the…”
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