Search Results - "Knappe, A"

The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A by Flühe, Leif, Knappe, Thomas A, Gattner, Michael J, Schäfer, Antje, Burghaus, Olaf, Linne, Uwe, Marahiel, Mohamed A

“…The unusual crosslinks between cysteine residues and the peptide backbone in the antibiotic peptide subtilosin A are formed by a new member of the radical SAM…”
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Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds by Wamhoff, Eike-Christian, Ronsard, Larance, Feldman, Jared, Knappe, Grant A., Hauser, Blake M., Romanov, Anna, Case, James Brett, Sanapala, Shilpa, Lam, Evan C., Denis, Kerri J. St, Boucau, Julie, Barczak, Amy K., Balazs, Alejandro B., Diamond, Michael S., Schmidt, Aaron G., Lingwood, Daniel, Bathe, Mark

“…Protein-based virus-like particles (P-VLPs) are commonly used to spatially organize antigens and enhance humoral immunity through multivalent antigen display…”
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Isolation and Structural Characterization of Capistruin, a Lasso Peptide Predicted from the Genome Sequence of Burkholderia thailandensis E264 by Knappe, Thomas A, Linne, Uwe, Zirah, Séverine, Rebuffat, Sylvie, Xie, Xiulan, Marahiel, Mohamed A

“…Lasso peptides are a structurally unique class of bioactive peptides characterized by a knotted arrangement, where the C-terminus threads through an N-terminal…”
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Bacterial Chaperone Domain Insertions Convert Human FKBP12 into an Excellent Protein-Folding Catalyst-A Structural and Functional Analysis by Žoldák, Gabriel, Knappe, Thomas A, Geitner, Anne-Juliane, Scholz, Christian, Dobbek, Holger, Schmid, Franz X, Jakob, Roman P

“…Many folding enzymes use separate domains for the binding of substrate proteins and for the catalysis of slow folding reactions such as prolyl isomerization…”
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Rational Improvement of the Affinity and Selectivity of Integrin Binding of Grafted Lasso Peptides by Hegemann, Julian D, De Simone, Mariarosaria, Zimmermann, Marcel, Knappe, Thomas A, Xie, Xiulan, Di Leva, Francesco Saverio, Marinelli, Luciana, Novellino, Ettore, Zahler, Stefan, Kessler, Horst, Marahiel, Mohamed A

“…Integrins moderate diverse important functions in the human body and are promising targets in cancer therapy. Hence, the selective inhibition of specific…”
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A conformal array of microfabricated optically-pumped first-order gradiometers for magnetoencephalography by Nardelli, N. V., Perry, A. R., Krzyzewski, S. P., Knappe, S. A.

“…An array of 21 first-order gradiometers based on zero-field optically-pumped magnetometers is demonstrated for use in magnetoencephalography. Sensors are…”
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Dissecting the Maturation Steps of the Lasso Peptide Microcin J25 in vitro by Yan, Kok-Phen, Li, Yanyan, Zirah, Séverine, Goulard, Christophe, Knappe, Thomas A., Marahiel, Mohamed A., Rebuffat, Sylvie

“…Microcin J25 is the archetype of a growing class of bacterial ribosomal peptides possessing a knotted topology (lasso peptides). It consists of an…”
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The glucagon receptor antagonist BI-32169 constitutes a new class of lasso peptides by Knappe, Thomas A., Linne, Uwe, Xie, Xiulan, Marahiel, Mohamed A.

“…The glucagon receptor antagonist BI-32169, recently isolated from Streptomyces sp., was described as a bicyclic peptide, although its primary structure…”
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The Antibacterial Threaded-lasso Peptide Capistruin Inhibits Bacterial RNA Polymerase by Kuznedelov, Konstantin, Semenova, Ekaterina, Knappe, Thomas A., Mukhamedyarov, Damir, Srivastava, Aashish, Chatterjee, Sujoy, Ebright, Richard H., Marahiel, Mohamed A., Severinov, Konstantin

“…Capistruin, a ribosomally synthesized, post-translationally modified peptide produced by Burkholderia thailandensis E264, efficiently inhibits growth of…”
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The impact of variable temperatures on the redox conditions and the behaviour of pharmaceutical residues during artificial recharge by Massmann, G., Greskowiak, J., Dünnbier, U., Zuehlke, S., Knappe, A., Pekdeger, A.

“…The redox conditions below an artificial recharge pond in Berlin were largely dependent on seasonal temperature changes of 0–24 °C in the infiltrate. Aerobic…”
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Isolation, Structure Elucidation, and Biosynthesis of an Unusual Hydroxamic Acid Ester-Containing Siderophore from Actinosynnema mirum by Giessen, Tobias W, Franke, Kamila B, Knappe, Thomas A, Kraas, Femke I, Bosello, Mattia, Xie, Xiulan, Linne, Uwe, Marahiel, Mohamed A

“…In this study we report the isolation, structure elucidation, and biosynthesis of mirubactin (1), a siderophore containing an unprecedented chemical…”
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Erythrochelin - a hydroxamate-type siderophore predicted from the genome of Saccharopolyspora erythraea by Robbel, Lars, Knappe, Thomas A, Linne, Uwe, Xie, Xiulan, Marahiel, Mohamed A

“…The class of nonribosomally assembled siderophores encompasses a multitude of structurally diverse natural products. The genome of the erythromycin-producing…”
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The interleukin-10 family of cytokines by Fickenscher, Helmut, Hör, Simon, Küpers, Heide, Knappe, Andrea, Wittmann, Sabine, Sticht, Heinrich

“…A family of interleukin-10 (IL-10)-related cytokines has emerged, comprising a series of herpesviral and poxviral members and several cellular sequence…”
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Microfabricated saturated absorption laser spectrometer by Knappe, Svenja A, Robinson, Hugh G, Hollberg, Leo

“…We demonstrate a miniature microfabricated saturated absorption laser spectrometer. The system consists of miniature optics, a microfabricated Rb vapor cell,…”
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Insertion of a Chaperone Domain Converts FKBP12 into a Powerful Catalyst of Protein Folding by Knappe, Thomas A., Eckert, Barbara, Schaarschmidt, Peter, Scholz, Christian, Schmid, Franz X.

“…The catalytic activity of human FKBP12 as a prolyl isomerase is high towards short peptides, but very low in proline-limited protein folding reactions. In…”
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Functionalizing DNA origami to investigate and interact with biological systems by Knappe, Grant A., Wamhoff, Eike-Christian, Bathe, Mark

“…DNA origami has emerged as a powerful method to generate DNA nanostructures with dynamic properties and nanoscale control. These nanostructures enable complex…”
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Reducing crosstalk in optically-pumped magnetometer arrays by Nardelli, N V, Krzyzewski, S P, Knappe, S A

“…Optically pumped magnetometers (OPMs) operating in the spin-exchange relaxation-free regime are emerging as alternative sensors to superconducting quantum…”
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In Situ Covalent Functionalization of DNA Origami Virus-like Particles by Knappe, Grant A, Wamhoff, Eike-Christian, Read, Benjamin J, Irvine, Darrell J, Bathe, Mark

“…DNA origami is a powerful nanomaterial for biomedical applications due in part to its capacity for programmable, site-specific functionalization. To realize…”
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Charge Detection Mass Spectrometry Enables Molecular Characterization of Nucleic Acid Nanoparticles by Ofoegbu, Polycarp C, Knappe, Grant A, Romanov, Anna, Draper, Benjamin E, Bathe, Mark, Jarrold, Martin F

“…Nucleic acid nanoparticles (NANPs) are increasingly used in preclinical investigations as delivery vectors. Tools that can characterize assembly and assess…”
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Controlling Nuclease Degradation of Wireframe DNA Origami with Minor Groove Binders by Wamhoff, Eike-Christian, Romanov, Anna, Huang, Hellen, Read, Benjamin J., Ginsburg, Eric, Knappe, Grant A., Kim, Hyun Min, Farrell, Nicholas P., Irvine, Darrell J., Bathe, Mark

“…Viruslike particles (VLPs) fabricated using wireframe DNA origami are emerging as promising vaccine and gene therapeutic delivery platforms due to their…”
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