Search Results - "Knapp, Anne‐Marie"

Severe combined immunodeficiency in stimulator of interferon genes (STING) V154M/wild-type mice by Bouis, Delphine, Kirstetter, Peggy, Arbogast, Florent, Lamon, Delphine, Delgado, Virginia, Jung, Sophie, Ebel, Claudine, Jacobs, Hugues, Knapp, Anne-Marie, Jeremiah, Nadia, Belot, Alexandre, Martin, Thierry, Crow, Yanick J., André-Schmutz, Isabelle, Korganow, Anne-Sophie, Rieux-Laucat, Frédéric, Soulas-Sprauel, Pauline

“…Autosomal dominant gain-of-function mutations in human stimulator of interferon genes (STING) lead to a severe autoinflammatory disease called STING-associated…”
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Normal B cells express ZAP70 in chronic lymphocytic leukemia: A link between autoimmunity and lymphoproliferation? by Ghergus, Dana, Martin, Mickaël, Knapp, Anne‐Marie, Delmotte, Fabien, Joublin‐Delavat, Aurélie, Jung, Sophie, Schickel, Jean‐Nicolas, Mendel, Isabelle, Dupuis, Arnaud, Drénou, Bernard, Ghesquières, Hervé, Salles, Gilles, Baseggio, Lucile, Herbrecht, Raoul, Korganow, Anne‐Sophie, Vallat, Laurent, Soulas‐Sprauel, Pauline, Meffre, Eric, Martin, Thierry

“…ZAP70 has a prognostic value in chronic lymphocytic leukemia (CLL), through altered B‐cell receptor signaling, which is important in CLL pathogenesis. A good…”
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Synovial fibroblasts promote immunoglobulin class switching by a mechanism involving BAFF by Alsaleh, Ghada, François, Antoine, Knapp, Anne‐Marie, Schickel, Jean‐Nicolas, Sibilia, Jean, Pasquali, Jean‐Louis, Gottenberg, Jacques‐Eric, Wachsmann, Dominique, Soulas‐Sprauel, Pauline

“…Fibroblast‐like synoviocytes (FLSs) are important actors in rheumatoid arthritis (RA) pathogenesis. The autoimmune nature of RA is attributed to autoantibody…”
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Chronic bacterial infection activates autoreactive B cells and induces isotype switching and autoantigen‐driven mutations by Jung, Sophie, Schickel, Jean‐Nicolas, Kern, Aurélie, Knapp, Anne‐Marie, Eftekhari, Pierre, Da Silva, Sylvia, Jaulhac, Benoît, Brink, Robert, Soulas‐Sprauel, Pauline, Pasquali, Jean‐Louis, Martin, Thierry, Korganow, Anne‐Sophie

“…The links between infections and the development of B‐cell‐mediated autoimmune diseases are still unclear. In particular, it has been suggested that…”
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B cell signature during inactive systemic lupus is heterogeneous: toward a biological dissection of lupus by Garaud, Jean-Claude, Schickel, Jean-Nicolas, Blaison, Gilles, Knapp, Anne-Marie, Dembele, Doulaye, Ruer-Laventie, Julie, Korganow, Anne-Sophie, Martin, Thierry, Soulas-Sprauel, Pauline, Pasquali, Jean-Louis

“…Systemic lupus erythematosous (SLE) is an autoimmune disease with an important clinical and biological heterogeneity. B lymphocytes appear central to the…”
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Peripheral B cell abnormalities in patients with systemic lupus erythematosus in quiescent phase: Decreased memory B cells and membrane CD19 expression by Korganow, Anne-Sophie, Knapp, Anne-Marie, Nehme-Schuster, Hélène, Soulas-Sprauel, Pauline, Poindron, Vincent, Pasquali, Jean-Louis, Martin, Thierry

“…Abstract B lymphocytes from patients with systemic lupus erythematosus (SLE) are hyperactive and produce autoantibodies. Several B cell phenotype…”
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Carabin deficiency in B cells increases BCR‐TLR9 costimulation‐induced autoimmunity by Schickel, Jean‐Nicolas, Pasquali, Jean‐Louis, Soley, Anne, Knapp, Anne‐Marie, Decossas, Marion, Kern, Aurélie, Fauny, Jean‐Daniel, Marcellin, Luc, Korganow, Anne‐Sophie, Martin, Thierry, Soulas‐Sprauel, Pauline

“…The mechanisms behind flares of human autoimmune diseases in general, and of systemic lupus in particular, are poorly understood. The present scenario proposes…”
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Overexpression of Fkbp11, a feature of lupus B cells, leads to B cell tolerance breakdown and initiates plasma cell differentiation by Ruer‐Laventie, Julie, Simoni, Léa, Schickel, Jean‐Nicolas, Soley, Anne, Duval, Monique, Knapp, Anne‐Marie, Marcellin, Luc, Lamon, Delphine, Korganow, Anne‐Sophie, Martin, Thierry, Pasquali, Jean‐Louis, Soulas‐Sprauel, Pauline

“…Systemic Lupus Erythematosus (SLE) is a severe systemic autoimmune disease, characterized by multi‐organ damages, triggered by an autoantibody‐mediated…”
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MyD88 Negatively Controls Hypergammaglobulinemia with Autoantibody Production during Bacterial Infection by Woods, Anne, Soulas-Sprauel, Pauline, Jaulhac, Benoit, Arditi, Bérénice, Knapp, Anne-Marie, Pasquali, Jean-Louis, Korganow, Anne-Sophie, Martin, Thierry

“…A large body of evidence has convincingly shown that Toll-like receptors are necessary sensors for infections with pathogens, but their activation was also…”
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Impaired TLR9 responses in B cells from patients with systemic lupus erythematosus by Gies, Vincent, Schickel, Jean-Nicolas, Jung, Sophie, Joublin, Aurélie, Glauzy, Salomé, Knapp, Anne-Marie, Soley, Anne, Poindron, Vincent, Guffroy, Aurélien, Choi, Jin-Young, Gottenberg, Jacques-Eric, Anolik, Jennifer H, Martin, Thierry, Soulas-Sprauel, Pauline, Meffre, Eric, Korganow, Anne-Sophie

“…B cells play a central role in systemic lupus erythematosus (SLE) pathophysiology but dysregulated pathways leading to a break in B cell tolerance remain…”
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A role for membrane IgD in the tolerance of pathological human rheumatoid factor B cells by Soulas, Pauline, Koenig‐Marrony, Severine, Julien, Sylvie, Knapp, Anne‐Marie, Garaud, Jean‐Claude, Pasquali, Jean‐Louis, Martin, Thierry

“…Under non‐autoimmune conditions, rheumatoid factor (RF) B cells coexist peacefully with their antigen (IgG), or can be transiently activated during secondary…”
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Autoantigen, innate immunity, and T cells cooperate to break B cell tolerance during bacterial infection by Soulas, Pauline, Woods, Anne, Jaulhac, Benoit, Knapp, Anne-Marie, Pasquali, Jean-Louis, Martin, Thierry, Korganow, Anne-Sophie

“…Autoantibody production during infections is considered to result from nonspecific activation of low-affinity autoreactive B cells. Whether this can lead to…”
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Pathogenic antiphospholipid antibody: an antigen-selected needle in a haystack by Lieby, Patricia, Poindron, Vincent, Roussi, Stamatiki, Klein, Cyril, Knapp, Anne-Marie, Garaud, Jean-Claude, Cerutti, Martine, Martin, Thierry, Pasquali, Jean-Louis

“…Antiphospholipid antibodies represent a heterogeneous group of autoantibodies directed against anionic phospholipids (PLs) usually linked to protein cofactors…”
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Memory B cells producing somatically mutated antiphospholipid antibodies are present in healthy individuals by Lieby, Patricia, Soley, Anne, Knapp, Anne-Marie, Cerutti, Martine, Freyssinet, Jean-Marie, Pasquali, Jean-Louis, Martin, Thierry

“…Antiphospholipid antibodies (aPLs) are associated with thrombosis and recurrent abortions during autoimmune pathologies, but they are also produced in healthy…”
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Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer by Sadras, Teresa, Martin, Mickaël, Kume, Kohei, Robinson, Mark E., Saravanakumar, Supraja, Lenz, Gal, Chen, Zhengshan, Song, Joo Y., Siddiqi, Tanya, Oksa, Laura, Knapp, Anne Marie, Cutler, Jevon, Cosgun, Kadriye Nehir, Klemm, Lars, Ecker, Veronika, Winchester, Janet, Ghergus, Dana, Soulas-Sprauel, Pauline, Kiefer, Friedemann, Heisterkamp, Nora, Pandey, Akhilesh, Ngo, Vu, Wang, Lili, Jumaa, Hassan, Buchner, Maike, Ruland, Jürgen, Chan, Wing-Chung, Meffre, Eric, Martin, Thierry, Müschen, Markus

“…Even though SYK and ZAP70 kinases share high sequence homology and serve analogous functions, their expression in B and T cells is strictly segregated…”
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Co-Expression of SYK and ZAP70 Subverts Negative B-Cell Selection and Enables Oncogenic Signaling in Multiple B-Cell Malignancies by Sadras, Teresa, Martin, Mickaël, Kim-Sing, Lauren, Cutler, Jevon, Lenz, Gal, Knapp, Anne Marie, Ghergus, Dana, Delmotte, Fabien, Schleiss, Cédric, Korganow, Anne-Sophie, Soulas-Sprauel, Pauline, Chen, Zhengshan, Pandey, Akhilesh, Weinstock, David M., Jumaa, Hassan, Meffre, Eric, Martin, Thierry, Müschen, Markus

“…B-cells are under intense selective pressure to eliminate autoreactive or premalignant clones. B-cell receptor (BCR) signals are required for survival,…”
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ZAP-70 Expression in Non Tumoral B Cells: Role in B Tolerance Breakdown? by Martin, Mickaël, Knapp, Anne Marie, Ghergus, Dana, Delmotte, Fabien, Vallat, Laurent, Schleiss, Cédric, Herbrecht, Raoul, Korganow, Anne-Sophie, Gros, Frédéric, Jung, Sophie, Soulas-Sprauel, Pauline, Meffre, Eric, Martin, Thierry

“…Abnormal expression of the tyrosine kinase ZAP-70 by tumoral B cells in chronic lymphocytic leukemia (CLL) is associated with bad prognosis, related to B cell…”
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A Percentage of Normal B Cells from CLL Patients Express ZAP-70, Which Is Associated with Autoimmunity and Could be Responsible for Arising of Malignant Clone by Ghergus, Dana, Knapp, Anne-Marie, Delmotte, Fabien, Martin, Mickael, Jung, Sophie, Schickel, Jean-Nicolas, Drenou, Bernard, Herbrecht, Raoul, Pasquali, Jean-Louis, Korganow, Anne-Sophie, Vallat, Laurent Daniel, Soulas-Sprauel, Pauline, Meffre, Eric, Martin, Thierry

“…Introduction Chronic lymphocytic leukemia (CLL) has the particularity of a dysregulated immune system that favors the development of autoimmunity (AI). The…”
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Infiltrating T cells from patients with primary Sjögren's syndrome express restricted or unrestricted T cell receptor V beta regions depending on the stage of the disease by Legras, F, Martin, T, Knapp, A M, Pasquali, J L

“…Organ-specific autoimmune diseases are usually considered to be mediated by autoreactive T cells which infiltrate the target tissue. Conceivably, these T cells…”
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Molecular analysis of rearranged VH genes during B cell chronic lymphocytic leukemia: intraclonal stability is frequent but not constant by Korganow, A S, Martin, T, Weber, J C, Lioure, B, Lutz, P, Knapp, A M, Pasquali, J L

“…Several genetic mechanisms have been shown to diversify the expressed antibody repertoire of committed B lymphocytes. These include V gene replacement, ongoing…”
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