Search Results - "Knable, Michael B"

Using the NIH Research, Condition and Disease Categorization Database for research advocacy: Schizophrenia research at NIMH as an example by Torrey, E Fuller, Knable, Michael B, Rush, A John, Simmons, Wendy W, Snook, John, Jaffe, D J

“…In 2008 the National Institutes of Health established the Research, Condition and Disease Categorization Database (RCDC) that reports the amount spent by NIH…”
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Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brains by Torrey, E. Fuller, Barci, Beata M., Webster, Maree J., Bartko, John J., Meador-Woodruff, James H., Knable, Michael B.

“…Previous studies of postmortem neurochemical markers in severe psychiatric disorders have been carried out on different brain collections, making it difficult…”
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Deficient Hippocampal Neuron Expression of Proteasome, Ubiquitin, and Mitochondrial Genes in Multiple Schizophrenia Cohorts by Altar, C. Anthony, Jurata, Linda W., Charles, Vin, Lemire, Andrew, Liu, Peng, Bukhman, Yury, Young, Theresa A., Bullard, Jeff, Yokoe, Hiroko, Webster, Maree J., Knable, Michael B., Brockman, Jeffrey A.

“…Hippocampal dentate granule neurons are altered in schizophrenia, but it is unknown if their gene expressions change in schizophrenia or other psychiatric…”
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Assessment of the 2019 national institute of mental health grant portfolio for bipolar disorder research by Knable, Michael B., Torrey, E. Fuller

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Putative psychosis genes in the prefrontal cortex: combined analysis of gene expression microarrays by Choi, Kwang Ho, Elashoff, Michael, Higgs, Brandon W, Song, Jonathan, Kim, Sanghyeon, Sabunciyan, Sarven, Diglisic, Suad, Yolken, Robert H, Knable, Michael B, Torrey, E Fuller, Webster, Maree J

“…Recent studies have shown similarities between schizophrenia and bipolar disorder in phenotypes and in genotypes, and those studies have contributed to an…”
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Dopamine, the prefrontal cortex and schizophrenia by Knable, M B, Weinberger, D R

“…Dysfunction of the prefrontal cortex (PFC) in schizophrenia has been suspected based on observations from clinical, neuropsychological and neuroimaging…”
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Multivariate analysis of prefrontal cortical data from the Stanley Foundation Neuropathology Consortium by Knable, Michael B, Torrey, E.Fuller, Webster, Maree J, Bartko, John J

“…Prefrontal cortical tissue from the Stanley Foundation Neuropathology Consortium, which contains samples from patients with schizophrenia, bipolar disorder,…”
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Schizophrenia as a developmental disorder of the cerebral cortex by Raedler, Thomas J, Knable, Michael B, Weinberger, Daniel R

“…The hypothesis that schizophrenia results from a developmental, as opposed to a degenerative, process affecting the cerebral cortex has become popular in…”
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The relationship between dorsolateral prefrontal N-acetylaspartate measures and striatal dopamine activity in schizophrenia by Bertolino, Alessandro, Knable, Michael B, Saunders, Richard C, Callicott, Joseph H, Kolachana, Bhaskar, Mattay, Venkata S, Bachevalier, Jocelyne, Frank, Joseph A, Egan, Michael, Weinberger, Daniel R

“…Background: Pathology of dorsolateral prefrontal cortex and dysregulation of dopaminergic neurons have been associated with the pathophysiology of…”
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In Vivo Determination of Muscarinic Acetylcholine Receptor Availability in Schizophrenia by Raedler, Thomas J., Knable, Michael B., Jones, Douglas W., Urbina, Richard A., Gorey, Julia G., Lee, Kan S., Egan, Michael F., Coppola, Richard, Weinberger, Daniel R.

“…OBJECTIVE: Postmortem studies have implicated the central muscarinic acetylcholine system in schizophrenia. However, central muscarinic receptor availability…”
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Meta-analysis of 12 genomic studies in bipolar disorder by Elashoff, Michael, Higgs, Brandon W, Yolken, Robert H, Knable, Michael B, Weis, Serge, Webster, Maree J, Barci, Beata M, Torrey, E Fuller

“…Multiple genome-wide expression studies of bipolar disorder have been published. However, a unified picture of the genomic basis for the disease has not yet…”
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Reduced Central Serotonin Transporters in Alcoholism by Heinz, Andreas, Ragan, Paul, Jones, Douglas W., Hommer, Dan, Williams, Wendol, Knable, Michael B., Gorey, Julia G., Doty, Linda, Geyer, Christopher, Lee, Kan S., Coppola, Richard, Weinberger, Daniel R., Linnoila, Markku

“…Objective:Dysfunction of monoamine uptake mechanisms has been implicated in the pathogenesis of alcohol dependence. The authors explored whether serotonergic…”
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Central Muscarinic Acetylcholine Receptor Availability in Patients Treated with Clozapine by RAEDLER, Thomas J, KNABLE, Michael B, JONES, Douglas W, URBINA, Richard A, EGAN, Michael F, WEINBERGER, Daniel R

“…Clozapine is the prototypical atypical antipsychotic. In vitro, clozapine antagonizes a broad range of receptors, including dopamine, serotonin and muscarinic…”
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Preliminary experience with an ampakine (CX516) as a single agent for the treatment of schizophrenia: a case series by Marenco, Stefano, Egan, Michael F, Goldberg, Terry E, Knable, Michael B, McClure, Robert K, Winterer, Georg, Weinberger, Daniel R

“…We used l-(quinoxalin-6-ylcarbonyl)piperidine (CX516) (a modulator of the α-amino-3-hydroxy-5-methyl-4-isoxasole propionic acid (AMPA) receptor) as a sole…”
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Tourette Syndrome: Prediction of Phenotypic Variation in Monozygotic Twins by Caudate Nucleus D2 Receptor Binding by Wolf, Steven S., Jones, Douglas W., Knable, Michael B., Gorey, Julia G., Lee, Kan Sam, Hyde, Thomas M., Coppola, Richard, Weinberger, Daniel R.

“…Tourette syndrome, a chronic tic disorder with autosomal dominant inheritance, exhibits considerable phenotypic variability even within monozygotic twin pairs…”
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In Vivo Olanzapine Occupancy of Muscarinic Acetylcholine Receptors in Patients with Schizophrenia by Raedler, Thomas J, Knable, Michael B, Jones, Douglas W, Lafargue, Todd, Urbina, Richard A, Egan, Michael F, Pickar, David, Weinberger, Daniel R

“…Olanzapine is an atypical antipsychotic with potent antimuscarinic properties in vitro (Ki = 2–25 nM). We studied in vivo muscarinic receptor occupancy by…”
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Secretin for refractory schizophrenia by Sheitman, Brian B., Knable, Michael B., Jarskog, L.Fredrik, Chakos, Miranda, Boyce, Leslie H., Early, John, Lieberman, Jeffrey A.

“…In preliminary uncontrolled studies, intravenous injection of the gastrointestinal peptide secretin produced improvements in the symptoms of autism. Because of…”
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Topiramate for Bulimia Nervosa in Epilepsy by KNABLE, MICHAEL B.

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Distribution of dopamine D1-D4 receptor subtypes in human dorsal vagal complex by Hyde, Thomas M., Knable, Michael B., Murray, Angela M.

“…The distribution of D1/D5, D2/D3, D2/D3/D4, and individually, putative D2‐D4 receptors across the dorsal vagal complex of the human medulla was assessed with…”
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Controlled trial of hydroxychloroquine in schizophrenia by DESTA, Menelik, TADESSE, Azeb, GEBRE, Negussie, BARCI, Beata M, TORREY, E. Fuller, KNABLE, Michael B

“…Hydroxychloroquine is widely employed for the treatment of rheumatological diseases. A preliminary pilot study suggested that hydroxychloroquine may be a…”
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