Search Results - "Kluza, Jerome"

Mitochondrial spare respiratory capacity: Mechanisms, regulation, and significance in non‐transformed and cancer cells by Marchetti, Philippe, Fovez, Quentin, Germain, Nicolas, Khamari, Raeeka, Kluza, Jérôme

“…Mitochondrial metabolism must constantly adapt to stress conditions in order to maintain bioenergetic levels related to cellular functions. This absence of…”
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Implication of Rac1 GTPase in molecular and cellular mitochondrial functions by Bailly, Christian, Degand, Claire, Laine, William, Sauzeau, Vincent, Kluza, Jérôme

“…Rac1 is a member of the Rho GTPase family which plays major roles in cell mobility, polarity and migration, as a fundamental regulator of actin cytoskeleton…”
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TRPC3 shapes the ER-mitochondria Ca2+ transfer characterizing tumour-promoting senescence by Farfariello, Valerio, Gordienko, Dmitri V., Mesilmany, Lina, Touil, Yasmine, Germain, Emmanuelle, Fliniaux, Ingrid, Desruelles, Emilie, Gkika, Dimitra, Roudbaraki, Morad, Shapovalov, George, Noyer, Lucile, Lebas, Mathilde, Allart, Laurent, Zienthal-Gelus, Nathalie, Iamshanova, Oksana, Bonardi, Franck, Figeac, Martin, Laine, William, Kluza, Jerome, Marchetti, Philippe, Quesnel, Bruno, Metzger, Daniel, Bernard, David, Parys, Jan B., Lemonnier, Loïc, Prevarskaya, Natalia

“…Cellular senescence is implicated in a great number of diseases including cancer. Although alterations in mitochondrial metabolism were reported as senescence…”
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Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner by Errea, Agustina, Cayet, Delphine, Marchetti, Philippe, Tang, Cong, Kluza, Jerome, Offermanns, Stefan, Sirard, Jean-Claude, Rumbo, Martin

“…Lactate is an essential component of carbon metabolism in mammals. Recently, lactate was shown to signal through the G protein coupled receptor 81 (GPR81) and…”
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Lipid Metabolism and Resistance to Anticancer Treatment by Germain, Nicolas, Dhayer, Mélanie, Boileau, Marie, Fovez, Quentin, Kluza, Jerome, Marchetti, Philippe

“…Metabolic reprogramming is crucial to respond to cancer cell requirements during tumor development. In the last decade, metabolic alterations have been shown…”
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Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells by Trabelsi, Mohamed-Sami, Daoudi, Mehdi, Prawitt, Janne, Ducastel, Sarah, Touche, Véronique, Sayin, Sama I., Perino, Alessia, Brighton, Cheryl A., Sebti, Yasmine, Kluza, Jérôme, Briand, Olivier, Dehondt, Hélène, Vallez, Emmanuelle, Dorchies, Emilie, Baud, Grégory, Spinelli, Valeria, Hennuyer, Nathalie, Caron, Sandrine, Bantubungi, Kadiombo, Caiazzo, Robert, Reimann, Frank, Marchetti, Philippe, Lefebvre, Philippe, Bäckhed, Fredrik, Gribble, Fiona M., Schoonjans, Kristina, Pattou, François, Tailleux, Anne, Staels, Bart, Lestavel, Sophie

“…Bile acids are signalling molecules, which activate the transmembrane receptor TGR5 and the nuclear receptor FXR. BA sequestrants (BAS) complex bile acids in…”
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Comparison of the in vivo genotoxicity of electronic and conventional cigarettes aerosols after subacute, subchronic and chronic exposures by Platel, Anne, Dusautoir, Romain, Kervoaze, Gwenola, Dourdin, Gonzague, Gateau, Eulalie, Talahari, Smaïl, Huot, Ludovic, Simar, Sophie, Ollivier, Anaïs, Laine, William, Kluza, Jérôme, Gosset, Philippe, Garçon, Guillaume, Anthérieu, Sébastien, Guidice, Jean-Marc Lo, Nesslany, Fabrice

“…Tobacco smoking is classified as a human carcinogen. A wide variety of new products, in particular electronic cigarettes (e-cigs), have recently appeared on…”
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The troglitazone derivative EP13 disrupts energy metabolism through respiratory chain complex I inhibition in breast cancer cells and potentiates the antiproliferative effect of glycolysis inhibitntriors by Muller, Claire, Lacroix-Malgras, Victorine, Kluza, Jérôme, Laine, William, Güler, Yonca, Bost, Frédéric, Boisbrun, Michel, Mazerbourg, Sabine, Flament, Stéphane

“…BackgroundThe metabolism of cancer cells generally differs from that of normal cells. Indeed, most cancer cells have a high rate of glycolysis, even at normal…”
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Glucose metabolism and NRF2 coordinate the antioxidant response in melanoma resistant to MAPK inhibitors by Khamari, Raeeka, Trinh, Anne, Gabert, Pierre Elliott, Corazao-Rozas, Paola, Riveros-Cruz, Samuel, Balayssac, Stephane, Malet-Martino, Myriam, Dekiouk, Salim, Joncquel Chevalier Curt, Marie, Maboudou, Patrice, Garçon, Guillaume, Ravasi, Laura, Guerreschi, Pierre, Mortier, Laurent, Quesnel, Bruno, Marchetti, Philippe, Kluza, Jerome

“…Targeted therapies as BRAF and MEK inhibitor combination have been approved as first-line treatment for BRAF-mutant melanoma. However, disease progression…”
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p65/RelA NF‐κB fragments generated by RIPK3 activity regulate tumorigenicity, cell metabolism, and stemness characteristics by Touil, Yasmine, Latreche‐Carton, Céline, Bouazzati, Hassiba El, Nugues, Anne‐Lucie, Jouy, Nathalie, Thuru, Xavier, Laine, William, Lepretre, Frederic, Figeac, Martin, Tardivel, Meryem, Kluza, Jérôme, Idziorek, Thierry, Quesnel, Bruno

“…Receptor‐interacting protein kinase 3 (RIPK3) can induce necroptosis, apoptosis, or cell proliferation and is silenced in several hematological malignancies…”
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Mitochondrial electron transport is the cellular target of the oncology drug elesclomol by Blackman, Ronald K, Cheung-Ong, Kahlin, Gebbia, Marinella, Proia, David A, He, Suqin, Kepros, Jane, Jonneaux, Aurelie, Marchetti, Philippe, Kluza, Jerome, Rao, Patricia E, Wada, Yumiko, Giaever, Guri, Nislow, Corey

“…Elesclomol is a first-in-class investigational drug currently undergoing clinical evaluation as a novel cancer therapeutic. The potent antitumor activity of…”
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A New Strategy to Preserve and Assess Oxygen Consumption in Murine Tissues by Kluza, Jerome, Peugnet, Victoriane, Daunou, Blanche, Laine, William, Kervoaze, Gwenola, Rémy, Gaëlle, Loyens, Anne, Maboudou, Patrice, Fovez, Quentin, Grangette, Corinne, Wolowczuk, Isabelle, Gosset, Philippe, Garçon, Guillaume, Marchetti, Philippe, Pinet, Florence, Pichavant, Muriel, Dubois-Deruy, Emilie

“…Mitochondrial dysfunctions are implicated in several pathologies, such as metabolic, cardiovascular, respiratory, and neurological diseases, as well as in…”
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Mitochondrial inhibitors circumvent adaptive resistance to venetoclax and cytarabine combination therapy in acute myeloid leukemia by Bosc, Claudie, Saland, Estelle, Bousard, Aurélie, Gadaud, Noémie, Sabatier, Marie, Cognet, Guillaume, Farge, Thomas, Boet, Emeline, Gotanègre, Mathilde, Aroua, Nesrine, Mouchel, Pierre-Luc, Polley, Nathaniel, Larrue, Clément, Kaphan, Eléonore, Picard, Muriel, Sahal, Ambrine, Jarrou, Latifa, Tosolini, Marie, Rambow, Florian, Cabon, Florence, Nicot, Nathalie, Poillet-Perez, Laura, Wang, Yujue, Su, Xiaoyang, Fovez, Quentin, Kluza, Jérôme, Argüello, Rafael José, Mazzotti, Céline, Avet-Loiseau, Hervé, Vergez, François, Tamburini, Jérôme, Fournié, Jean-Jacques, Tiong, Ing S, Wei, Andrew H, Kaoma, Tony, Marine, Jean-Christophe, Récher, Christian, Stuani, Lucille, Joffre, Carine, Sarry, Jean-Emmanuel

“…Therapy resistance represents a major clinical challenge in acute myeloid leukemia (AML). Here we define a 'MitoScore' signature, which identifies high…”
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Metabolic features of melanoma: a gold mine of new therapeutic targets? by Marchetti, Philippe, Guerreschi, Pierre, Kluza, Jérôme, Mortier, Laurent

“…In recent years, our knowledge regarding the metabolism of melanoma has greatly advanced and consequently new therapeutic strategies are being developed. This…”
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Integration of Mitochondrial Targeting for Molecular Cancer Therapeutics by Kluza, Jerome, Mortier, Laurent, Guerreschi, Pierre, Marchetti, Philippe

“…Mitochondrial metabolism greatly influences cancer cell survival, invasion, metastasis, and resistance to many anticancer drugs. Furthermore,…”
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Antimetabolic cooperativity with the clinically approved l-asparaginase and tyrosine kinase inhibitors to eradicate CML stem cells by Trinh, Anne, Khamari, Raeeka, Fovez, Quentin, Mahon, François-Xavier, Turcq, Béatrice, Bouscary, Didier, Maboudou, Patrice, Joncquel, Marie, Coiteux, Valérie, Germain, Nicolas, Laine, William, Dekiouk, Salim, Jean-Pierre, Sandrine, Maguer-Satta, Veronique, Ghesquiere, Bart, Idziorek, Thierry, Quesnel, Bruno, Kluza, Jerome, Marchetti, Philippe

“…Long-term treatment with tyrosine kinase inhibitors (TKI) represents an effective cure for chronic myeloid leukemia (CML) patients and discontinuation of TKI…”
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Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78 by Kotecha, Minal, Kluza, Jerome, Wells, Geoff, O'Hare, C Caroline, Forni, Claudia, Mantovani, Roberto, Howard, Philip W, Morris, Peter, Thurston, David E, Hartley, John A, Hochhauser, Daniel

“…Many genes involved in cell cycle control have promoters that bind the heterotrimeric transcription factor NF-Y. Several minor-groove binding drugs have been…”
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Targeting chelatable iron as a therapeutic modality in Parkinson's disease by Devos, David, Moreau, Caroline, Devedjian, Jean Christophe, Kluza, Jérome, Petrault, Maud, Laloux, Charlotte, Jonneaux, Aurélie, Ryckewaert, Gilles, Garçon, Guillaume, Rouaix, Nathalie, Duhamel, Alain, Jissendi, Patrice, Dujardin, Kathy, Auger, Florent, Ravasi, Laura, Hopes, Lucie, Grolez, Guillaume, Firdaus, Wance, Sablonnière, Bernard, Strubi-Vuillaume, Isabelle, Zahr, Noel, Destée, Alain, Corvol, Jean-Christophe, Pöltl, Dominik, Leist, Marcel, Rose, Christian, Defebvre, Luc, Marchetti, Philippe, Cabantchik, Z Ioav, Bordet, Régis

“…The pathophysiological role of iron in Parkinson's disease (PD) was assessed by a chelation strategy aimed at reducing oxidative damage associated with…”
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Mitochondrial adaptation decreases drug sensitivity of persistent triple negative breast cancer cells surviving combinatory and sequential chemotherapy by Winter, Marie, Nait Eldjoudi, Amina, Guette, Catherine, Hondermarck, Hubert, Bourette, Roland P, Fovez, Quentin, Laine, William, Ghesquiere, Bart, Adriaenssens, Eric, Kluza, Jérôme, Le Bourhis, Xuefen

“…Triple negative breast cancer (TNBC) is an aggressive malignancy for which chemotherapy remains the standard treatment. However, between 3 and 5 years after…”
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Relationships between DNA strand breakage and apoptotic progression upon treatment of HL-60 leukemia cells with tafluposide or etoposide by Kluza, Jérôme, Mazinghien, Romain, Irwin, Helen, Hartley, John A, Bailly, Christian

“…Tafluposide (F11782), an epipodophyllotoxin derivative currently undergoing phase I clinical trials, is structurally close to the established anti-cancer drug…”
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