Search Results - "Kluth, David"

Utility of renal biopsy in the clinical management of renal disease by Dhaun, Neeraj, Bellamy, Christopher O, Cattran, Daniel C, Kluth, David C

“…Characterizing chronic kidney disease (CKD) at all stages is an essential part of rational management and the renal biopsy plays a key role in defining the…”
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A novel role for myeloid endothelin-B receptors in hypertension by Czopek, Alicja, Moorhouse, Rebecca, Guyonnet, Léa, Farrah, Tariq, Lenoir, Olivia, Owen, Elizabeth, van Bragt, Job, Costello, Hannah M, Menolascina, Filippo, Baudrie, Véronique, Webb, David J, Kluth, David C, Bailey, Matthew A, Tharaux, Pierre-Louis, Dhaun, Neeraj

“…Abstract Aims Hypertension is common. Recent data suggest that macrophages (Mφ) contribute to, and protect from, hypertension. Endothelin-1 (ET-1) is the most…”
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Effect of remote online exam delivery on student experience and performance in applied knowledge tests by Jaap, Alan, Dewar, Avril, Duncan, Colin, Fairhurst, Karen, Hope, David, Kluth, David

“…The use of remote online delivery of summative assessments has been underexplored in medical education. Due to the COVID-19 pandemic, all end of year applied…”
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Long-term outcomes in elderly patients with ANCA-associated vasculitis by McGovern, Dominic, Williams, Sam P, Parsons, Katrina, Farrah, Tariq E, Gallacher, Peter J, Miller-Hodges, Eve, Kluth, David C, Hunter, Robert W, Dhaun, Neeraj

“…Abstract Objective ANCA-associated vasculitis (AAV) is a small vessel vasculitis that commonly presents in the elderly. However, there are few long-term…”
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Endothelin‐1 and the kidney – beyond BP by Dhaun, Neeraj, Webb, David J, Kluth, David C

“…Since its discovery over 20 years ago endothelin‐1 (ET‐1) has been implicated in a number of physiological and pathophysiological processes. Its role in the…”
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Endothelin blockade prevents the long-term cardiovascular and renal sequelae of acute kidney injury in mice by Czopek, Alicja, Moorhouse, Rebecca, Gallacher, Peter J, Pugh, Dan, Ivy, Jessica R, Farrah, Tariq E, Godden, Emily, Hunter, Robert W, Webb, David J, Tharaux, Pierre-Louis, Kluth, David C, Dear, James W, Bailey, Matthew A, Dhaun, Neeraj

“…Acute kidney injury (AKI) is common and associated with increased risks of cardiovascular and chronic kidney disease. Causative molecular/physiological…”
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Working with Commercially Available Quantum Dots for Immunofluorescence on Tissue Sections by Prost, Sandrine, Kishen, Ria E B, Kluth, David C, Bellamy, Christopher O C

“…Quantum dots are semiconductor fluorescent nanocrystals that exhibit excellent characteristics compared with more commonly used organic fluorescent dyes. For…”
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Macrophage/monocyte depletion by clodronate, but not diphtheria toxin, improves renal ischemia/reperfusion injury in mice by Ferenbach, David A, Sheldrake, Tara A, Dhaliwal, Kevin, Kipari, Tiina M J, Marson, Lorna P, Kluth, David C, Hughes, Jeremy

“…The role of resident renal mononuclear phagocytes in acute kidney injury is controversial with experimental data suggesting both deleterious and protective…”
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Infusion of IL-10-expressing cells protects against renal ischemia through induction of lipocalin-2 by Jung, Michaela, Sola, Anna, Hughes, Jeremy, Kluth, David C, Vinuesa, Eugenia, Viñas, Jose Luis, Pérez-Ladaga, Albert, Hotter, Georgina

“…Ischemia/reperfusion injury is a leading cause of acute renal failure triggering an inflammatory response associated with infiltrating macrophages, which…”
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Utility of interval kidney biopsy in ANCA-associated vasculitis by Chapman, Gavin B, Farrah, Tariq E, Chapman, Fiona A, Pugh, Dan, Bellamy, Christopher O C, Lahiri, Rashmi, Miller-Hodges, Eve, Kluth, David C, Hunter, Robert W, Dhaun, Neeraj

“…Abstract Objectives ANCA-associated vasculitis (AAV) is a rare autoimmune disorder that commonly involves the kidney. Early identification of kidney…”
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Circulating IgM Requires Plasma Membrane Disruption to Bind Apoptotic and Non-Apoptotic Nucleated Cells and Erythrocytes by Hesketh, Emily E, Dransfield, Ian, Kluth, David C, Hughes, Jeremy

“…Autoimmunity is associated with defective phagocytic clearance of apoptotic cells. IgM deficient mice exhibit an autoimmune phenotype consistent with a role…”
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Variation in passing standards for graduation‐level knowledge items at UK medical schools by Taylor, Celia A, Gurnell, Mark, Melville, Colin R, Kluth, David C, Johnson, Neil, Wass, Val

“…Objectives Given the absence of a common passing standard for students at UK medical schools, this paper compares independently set standards for common ‘one…”
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Macrophages Expressing Heme Oxygenase-1 Improve Renal Function in Ischemia/Reperfusion Injury by Ferenbach, David A, Ramdas, Vasudev, Spencer, Nishrin, Marson, Lorna, Anegon, Ignacio, Hughes, Jeremy, Kluth, David C

“…Acute kidney injury has a high mortality and lacks specific therapies, with ischemia/reperfusion injury (IRI) being the predominant cause. Macrophages (Mϕ)…”
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Unique Expression of Suppressor of Cytokine Signaling 3 Is Essential for Classical Macrophage Activation in Rodents In Vitro and In Vivo by Liu, Yu, Stewart, Keith N, Bishop, Eileen, Marek, Carylyn J, Kluth, David C, Rees, Andrew J, Wilson, Heather M

“…On infiltrating inflamed tissue, macrophages respond to the local microenvironment and develop one of two broad phenotypes: classically activated (M1)…”
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Hemin Preconditioning Upregulates Heme Oxygenase-1 in Deceased Donor Renal Transplant Recipients: A Randomized, Controlled, Phase IIB Trial by Thomas, Rachel A B, Czopek, Alicja, Bellamy, Christopher O C, McNally, Stephen J, Kluth, David C, Marson, Lorna P

“…BACKGROUNDThe enzyme heme oxygenase-1 (HO-1) degrades heme and protects against ischemia-reperfusion injury. Monocytes/macrophages are the major source of HO-1…”
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Variation in performance on common content items at UK medical schools by Hope, David, Kluth, David, Homer, Matthew, Dewar, Avril, Fuller, Richard, Cameron, Helen

“…Abstract Background Due to differing assessment systems across UK medical schools, making meaningful cross-school comparisons on undergraduate students’…”
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Choice of Illumination System & Fluorophore for Multiplex Immunofluorescence on FFPE Tissue Sections by Prost, Sandrine, Kishen, Ria E B, Kluth, David C, Bellamy, Christopher O C

“…The recent availability of novel dyes and alternative light sources to facilitate complex tissue immunofluorescence studies such as multiplex labelling has not…”
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Computed Tomography Angiography in the Diagnosis of ANCA-Associated Small- and Medium-Vessel Vasculitis by Dhaun, Neeraj, MD, PhD, Patel, Dilip, MD, Kluth, David C., MD, PhD

“…Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis that typically occurs without detectable antineutrophil cytoplasmic antibody. It leads to…”
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In absentia: lupus-like nephritis with seronegative antiphospholipid syndrome by Stewart, Ruaraidh F., MB BChir, Bellamy, Christopher O.C., MDPhD, FRCPath, Kluth, David C., MDPhD, Dhaun, Neeraj, MDPhD

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Strawberry gums by Hunter, Robert W, Kluth, David C, Dhaun, Neeraj

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