Search Results - "Kluskens, Leon D."

A thermostable salmonella phage endolysin, Lys68, with broad bactericidal properties against gram-negative pathogens in presence of weak acids by Oliveira, Hugo, Thiagarajan, V., Walmagh, Maarten, Sillankorva, Sanna, Lavigne, Rob, Petersen, T. Neves, Kluskens, Leon, Azeredo, Joana

“…Resistance rates are increasing among several problematic Gram-negative pathogens, a fact that has encouraged the development of new antimicrobial agents. This…”
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Molecular Aspects and Comparative Genomics of Bacteriophage Endolysins by Oliveira, Hugo Alexandre Mendes, Melo, Luís D. R., Santos, Sílvio Roberto Branco, Nóbrega, Franklin Luzia, Ferreira, Eugénio C., Cerca, Nuno, Azeredo, Joana, Kluskens, Leon

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Bacteriophage endolysins as a response to emerging foodborne pathogens by Oliveira, Hugo, Azeredo, Joana, Lavigne, Rob, Kluskens, Leon. D.

“…Continuous reports on foodborne outbreaks and increasing prevalence of antibiotic-resistant bacteria call for the development of novel preservation techniques…”
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Structural and enzymatic characterization of ABgp46, a novel phage endolysin with broad anti-Gram-negative bacterial activity by Oliveira, Hugo Alexandre Mendes, Boas, Diana Patrícia Andrade Vilas, Mesnage, Stéphane, Kluskens, Leon, Lavigne, Rob, Sillankorva, Sanna, Secundo, Francesco, Azeredo, Joana

“…The present study demonstrates the antibacterial potential of a phage endolysin against Gram-negative pathogens, particularly against multidrug resistant…”
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Selection of novel peptides homing the 4T1 CELL line: exploring alternative targets for triple negative breast cancer by Silva, V., Ferreira, Débora, Nóbrega, Franklin Luzia, Martins, Ivone M., Kluskens, Leon, Rodrigues, L. R.

“…The use of bacteriophages to select novel ligands has been widely explored for cancer therapy. Their application is most warranted in cancer subtypes lacking…”
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Requirements of the Engineered Leader Peptide of Nisin for Inducing Modification, Export, and Cleavage by Plat, Annechien, Kluskens, Leon D, Kuipers, Anneke, Rink, Rick, Moll, Gert N

“…Nisin A is a pentacyclic peptide antibiotic produced by Lactococcus lactis. The leader peptide of prenisin keeps nisin inactive and has a role in inducing…”
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Angiotensin-(1-7) with thioether bridge: an angiotensin-converting enzyme-resistant, potent angiotensin-(1-7) analog by Kluskens, Leon D, Nelemans, S Adriaan, Rink, Rick, de Vries, Louwe, Meter-Arkema, Anita, Wang, Yong, Walther, Thomas, Kuipers, Anneke, Moll, Gert N, Haas, Marijke

“…The in vivo efficacy of many therapeutic peptides is hampered by their rapid proteolytic degradation. Cyclization of these therapeutic peptides is an excellent…”
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Unexploited opportunities for phage therapy by Oliveira, Hugo, Sillankorva, Sanna, Merabishvili, Maia, Kluskens, Leon D, Azeredo, Joana

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Dissection and Modulation of the Four Distinct Activities of Nisin by Mutagenesis of Rings A and B and by C-Terminal Truncation by Rink, Rick, Wierenga, Jenny, Kuipers, Anneke, Kluskens, Leon D, Driessen, Arnold J.M, Kuipers, Oscar P, Moll, Gert N

“…Nisin A is a pentacyclic antibiotic peptide produced by various Lactococcus lactis strains. Nisin displays four different activities: (i) it autoinduces its…”
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The first Paenibacillus larvae bacteriophage endolysin (PlyPl23) with high potential to control American foulbrood by Oliveira, A., Leite, Marta, Kluskens, Leon, Santos, Sílvio Roberto Branco, Melo, Luís D. R., Azeredo, Joana

“…Endolysins, which are peptidoglycan-degrading enzymes expressed during the terminal stage of the reproduction cycle of bacteriophages, have great potential to…”
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Production of curcuminoids from tyrosine by a metabolically engineered Escherichia coli using caffeic acid as an intermediate by Rodrigues, Joana L., Araújo, Rafael G., Prather, Kristala L. J., Kluskens, Leon D., Rodrigues, Ligia R.

“…Curcuminoids are phenylpropanoids with high pharmaceutical potential. Herein, we report an engineered artificial pathway in Escherichia coli to produce natural…”
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M13 phage grafted with peptide motifs as a tool to detect amyloid-β oligomers in brain tissue by Martins, Ivone M., Lima, Alexandre, de Graaff, Wim, Cristóvão, Joana S., Brosens, Niek, Aronica, Eleonora, Kluskens, Leon D., Gomes, Cláudio M., Azeredo, Joana, Kessels, Helmut W.

“…Oligomeric clusters of amyloid-β (Aβ) are one of the major biomarkers for Alzheimer’s disease (AD). However, proficient methods to detect Aβ-oligomers in brain…”
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Post-translational Modification of Therapeutic Peptides By NisB, the Dehydratase of the Lantibiotic Nisin by Kluskens, Leon D, Kuipers, Anneke, Rink, Rick, de Boef, Esther, Fekken, Susan, Driessen, Arnold J. M, Kuipers, Oscar P, Moll, Gert N

“…Post-translationally introduced dehydroamino acids often play an important role in the activity and receptor specificity of biologically active peptides. In…”
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NisC, the Cyclase of the Lantibiotic Nisin, Can Catalyze Cyclization of Designed Nonlantibiotic Peptides by Rink, Rick, Kluskens, Leon D, Kuipers, Anneke, Driessen, Arnold J. M, Kuipers, Oscar P, Moll, Gert N

“…Nisin is a pentacyclic peptide antibiotic active against Gram-positive bacteria. Its thioether rings are formed by two enzymatic steps:  nisin dehydratase…”
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Correction to: The first Paenibacillus larvae bacteriophage endolysin (PlyPl23) with high potential to control American foulbrood by Oliveira, A., Leite, Marta, Kluskens, Leon, Santos, Sílvio Roberto Branco, Melo, Luís D. R., Azeredo, Joana

“…The Data Availability statement for this paper is incorrect. The correct statement is: All relevant data are within the paper and its Supporting Information…”
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Production of Dehydroamino Acid-Containing Peptides by Lactococcus lactis by Rink, Rick, Wierenga, Jenny, Kuipers, Anneke, Kluskens, Leon D, Driessen, Arnold J.M, Kuipers, Oscar P, Moll, Gert N

“…Nisin is a pentacyclic peptide antibiotic produced by some Lactococcus lactis strains. Nisin contains dehydroresidues and thioether rings that are…”
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NisT, the Transporter of the Lantibiotic Nisin, Can Transport Fully Modified, Dehydrated, and Unmodified Prenisin and Fusions of the Leader Peptide with Non-lantibiotic Peptides by Kuipers, Anneke, de Boef, Esther, Rink, Rick, Fekken, Susan, Kluskens, Leon D, Driessen, Arnold J M, Leenhouts, Kees, Kuipers, Oscar P, Moll, Gert N

“…Lantibiotics are lanthionine-containing peptide antibiotics. Nisin, encoded by nisA , is a pentacyclic lantibiotic produced by some Lactococcus lactis strains…”
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Mechanistic Dissection of the Enzyme Complexes Involved in Biosynthesis of Lacticin 3147 and Nisin by Kuipers, Anneke, Meijer-Wierenga, Jenny, Rink, Rick, Kluskens, Leon D, Moll, Gert N

“…The thioether rings in the lantibiotics lacticin 3147 and nisin are posttranslationally introduced by dehydration of serines and threonines, followed by…”
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Sec-Mediated Transport of Posttranslationally Dehydrated Peptides in Lactococcus lactis by Kuipers, Anneke, Wierenga, Jenny, Rink, Rick, Kluskens, Leon D, Driessen, Arnold J.M, Kuipers, Oscar P, Moll, Gert N

“…Nisin is a lanthionine-containing antimicrobial peptide produced by Lactococcus lactis. Its (methyl)lanthionines are introduced by two posttranslational…”
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Influence of Shifting Positions of Ser, Thr, and Cys Residues in Prenisin on the Efficiency of Modification Reactions and on the Antimicrobial Activities of the Modified Prepeptides by Lubelski, Jacek, Overkamp, Wout, Kluskens, Leon D, Moll, Gert N, Kuipers, Oscar P

“…Since the recent discovery that the nisin modification and transport machinery can be used to produce and modify peptides unrelated to nisin, specific…”
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