Search Results - "Klushevskaya, Elena S."
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Induction of the Erythroid Differentiation of K562 Cells Is Coupled with Changes in the Inter-Chromosomal Contacts of rDNA Clusters
Published in International journal of molecular sciences (01-06-2023)“…The expression of clusters of rDNA genes influences pluripotency; however, the underlying mechanisms are not yet known. These clusters shape inter-chromosomal…”
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Preferential Co-Expression and Colocalization of rDNA-Contacting Genes with LincRNAs Suggest Their Involvement in Shaping Inter-Chromosomal Interactions with Nucleoli
Published in International journal of molecular sciences (07-06-2024)“…Different developmental genes shape frequent dynamic inter-chromosomal contacts with rDNA units in human and cells. In the course of differentiation, changes…”
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Strong Activation of ID1 , ID2 , and ID3 Genes Is Coupled with the Formation of Vasculogenic Mimicry Phenotype in Melanoma Cells
Published in International journal of molecular sciences (01-09-2024)“…Gene expression patterns are very sensitive to external influences and are reflected in phenotypic changes. It was previously described that transferring…”
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Fragments of rDNA Genes Scattered over the Human Genome Are Targets of Small RNAs
Published in International journal of molecular sciences (10-03-2022)“…Small noncoding RNAs of different origins and classes play several roles in the regulation of gene expression. Here, we show that diverged and rearranged…”
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Genes Possessing the Most Frequent DNA DSBs Are Highly Associated with Development and Cancers, and Essentially Overlap with the rDNA-Contacting Genes
Published in International journal of molecular sciences (28-06-2022)“…Double-strand DNA breakes (DSBs) are the most deleterious and widespread examples of DNA damage. They inevitably originate from endogenous mechanisms in the…”
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rDNA Clusters Make Contact with Genes that Are Involved in Differentiation and Cancer and Change Contacts after Heat Shock Treatment
Published in Cells (Basel, Switzerland) (05-11-2019)“…Human rDNA clusters form numerous contacts with different chromosomal regions as evidenced by chromosome conformation capture data. Heterochromatization of…”
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Dynamics of Whole-Genome Contacts of Nucleoli in Drosophila Cells Suggests a Role for rDNA Genes in Global Epigenetic Regulation
Published in Cells (Basel, Switzerland) (03-12-2020)“…Chromosomes are organized into 3D structures that are important for the regulation of gene expression and differentiation. Important role in formation of…”
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Chromosomal Translocations in NK-Cell Lymphomas Originate from Inter-Chromosomal Contacts of Active rDNA Clusters Possessing Hot Spots of DSBs
Published in Cancers (02-08-2021)“…Endogenous hot spots of DNA double-strand breaks (DSBs) are tightly linked with transcription patterns and cancer. There are nine hot spots of DSBs (denoted…”
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Highly Productive Pine Forests in a Changing Climate
Published in Izvestiâ vysših učebnyh zavedenij. Lesnoj žurnal (01-12-2021)“…Forest steppe of the Central Chernozem Region (CCR) of Russia belongs to the zone of highly productive pine forests. In 2015, for the first time a partial…”
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