Search Results - "Klunk, W"

Imaging beta-amyloid plaques and neurofibrillary tangles in the aging human brain by Mathis, C A, Wang, Y, Klunk, W E

“…The development of radioligands to image beta-amyloid (A beta) plaques and neurofibrillary tangles (NFTs) in vivo in the aging human brain is an important and…”
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[11C]PIB in a nondemented population : Potential antecedent marker of Alzheimer disease by MINTUN, M. A, LAROSSA, G. N, SHELINE, Y. I, DENCE, C. S, LEE, S. Y, MACH, R. H, KLUNK, W. E, MATHIS, C. A, DEKOSKY, S. T, MORRIS, J. C

“…Beta-amyloid (Abeta) plaques are the hallmark of Alzheimer disease (AD). A PET imaging tracer that binds to Abeta plaques in vivo,…”
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Imaging β-amyloid burden in aging and dementia by ROWE, C. C, NG, S, SMITH, C, WOODWARD, M, MERORY, J, TOCHON-DANGUY, H, O'KEEFE, G, KLUNK, W. E, MATHIS, C. A, PRICE, J. C, MASTERS, C. L, VILLEMAGNE, V. L, ACKERMANN, U, GONG, S. J, PIKE, K, SAVAGE, G, COWIE, T. F, DICKINSON, K. L, MARUFF, P, DARBY, D

“…To compare brain beta-amyloid (Abeta) burden measured with [(11)C]Pittsburgh Compound B (PIB) PET in normal aging, Alzheimer disease (AD), and other dementias…”
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Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB by RESNICK, S. M, SOJKOVA, J, KRAUT, M. A, WONG, D. F, ZHOU, Y, AN, Y, YE, W, HOLT, D. P, DANNALS, R. F, MATHIS, C. A, KLUNK, W. E, FERRUCCI, L

“…To investigate whether longitudinal declines in cognition are associated with higher fibrillar amyloid-beta (Abeta) deposition in vivo in individuals without…”
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Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease by Lopez, O L, Becker, J T, Wahed, A S, Saxton, J, Sweet, R A, Wolk, D A, Klunk, W, DeKosky, S T

“…Background:Patients using cholinesterase inhibitors (ChEIs) have a delay in nursing home (NH) admission compared with those who were not using the medication…”
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Plasma biosignature and brain pathology related to persistent cognitive impairment in late-life depression by Diniz, B S, Sibille, E, Ding, Y, Tseng, G, Aizenstein, H J, Lotrich, F, Becker, J T, Lopez, O L, Lotze, M T, Klunk, W E, Reynolds, C F, Butters, M A

“…Cognitive impairment is highly prevalent among individuals with late-life depression (LLD) and tends to persist even after successful treatment. The biological…”
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Imaging amyloid deposition in Lewy body diseases by Gomperts, S N, Rentz, D M, Moran, E, Becker, J A, Locascio, J J, Klunk, W E, Mathis, C A, Elmaleh, D R, Shoup, T, Fischman, A J, Hyman, B T, Growdon, J H, Johnson, K A

“…Extrapyramidal motor symptoms precede dementia in Parkinson disease (PDD) by many years, whereas dementia occurs early in dementia with Lewy bodies (DLB)…”
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Precuneus amyloid burden is associated with reduced cholinergic activity in Alzheimer disease by IKONOMOVIC, M. D, KLUNK, W. E, ABRAHAMSON, E. E, WUU, J, MATHIS, C. A, SCHEFF, S. W, MUFSON, E. J, DEKOSKY, S. T

“…This study examined the relationship between postmortem precuneus cholinergic enzyme activity, Pittsburgh compound B (PiB) binding, and soluble amyloid-β…”
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An improved algorithm of white matter hyperintensity detection in elderly adults by Ding, T, Cohen, AD, O’Connor, EE, Karim, HT, Crainiceanu, A, Muschelli, J, Lopez, O, Klunk, WE, Aizenstein, HJ, Krafty, R, Crainiceanu, CM, Tudorascu, DL

“…•OASIS-AD is a method for automatic segmentation of white matter hyperintensities in older adults using structural brain MRIs.•OASIS-AD is an approach evolved…”
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Imaging amyloid deposition in Lewy body diseases by GOMPERTS, S. N, RENTZ, D. M, HYMAN, B. T, GROWDON, J. H, JOHNSON, K. A, MORAN, E, BECKER, J. A, LOCASCIO, J. J, KLUNK, W. E, MATHIS, C. A, ELMALEH, D. R, SHOUP, T, FISCHMAN, A. J

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Relationship of amyloid beta and neurofibrillary tau deposition in Neurodegeneration in Aging Down Syndrome (NiAD) study at baseline by Tudorascu, DL, Laymon, CM, Zammit, M, Minhas, DS, Anderson, SJ, Ellison, PA, Zaman, S, Ances, BM, Sabbagh, M, Johnson, SC, Mathis, CA, Klunk, WE, Handen, BL, Christian, BT, Cohen, AD

“…Importance Adults with Down syndrome (DS) are at high‐risk of revealing Alzheimer's disease (AD) pathology, in part due to the triplication of chromosome 21…”
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Preclinical trials in autosomal dominant AD: Implementation of the DIAN-TU trial by Mills, S.M., Mallmann, J., Santacruz, A.M., Fuqua, A., Carril, M., Aisen, P.S., Althage, M.C., Belyew, S., Benzinger, T.L., Brooks, W.S., Buckles, V.D., Cairns, N.J., Clifford, D., Danek, A., Fagan, A.M., Farlow, M., Fox, N., Ghetti, B., Goate, A.M., Heinrichs, D., Hornbeck, R., Jack, C., Jucker, M., Klunk, W.E., Marcus, D.S., Martins, R.N., Masters, C.M., Mayeux, R., McDade, E., Morris, J.C., Oliver, A., Ringman, J.M., Rossor, M.N., Salloway, S., Schofield, P.R., Snider, J., Snyder, P., Sperling, R.A., Stewart, C., Thomas, R.G., Xiong, C., Bateman, R.J.

“…The Dominantly Inherited Alzheimer's Network Trials Unit (DIAN-TU) was formed to direct the design and management of interventional therapeutic trials of…”
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11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration by RABINOVICI, G. D, FURST, A. J, MATHIS, C. A, ROSEN, H. J, MILLER, B. L, JAGUST, W. J, O'NEIL, J. P, RACINE, C. A, MORMINO, E. C, BAKER, S. L, CHETTY, S, PATEL, P, PAGLIARO, T. A, KLUNK, W. E

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Imaging of CNS myelin by positron-emission tomography by Stankoff, Bruno, Wang, Yanming, Bottlaender, Michel, Aigrot, Marie-Stephane, Dolle, Frederic, Wu, Chunying, Feinstein, Douglas, Huang, Guo-Feng, Semah, Frank, Mathis, Chester A, Klunk, William, Gould, Robert M, Lubetzki, Catherine, Zalc, Bernard

“…Promoting myelin repair is one of the most promising therapeutic avenues in the field of myelin disorders. In future clinical trials, evaluation of…”
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X-34, A Fluorescent Derivative of Congo Red: A Novel Histochemical Stain for Alzheimer's Disease Pathology by Styren, Scot D, Hamilton, Ronald L, Styren, Gisele C, Klunk, William E

“…X-34, a lipophilic, highly fluorescent derivative of Congo red, was examined as a histochemical stain for pathological changes in Alzheimer's disease (AD)…”
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Amyloid Deposition Begins in the Striatum of Presenilin-1 Mutation Carriers from Two Unrelated Pedigrees by Klunk, William E, Price, Julie C, Mathis, Chester A, Tsopelas, Nicholas D, Lopresti, Brian J, Ziolko, Scott K, Bi, Wenzhu, Hoge, Jessica A, Cohen, Ann D, Ikonomovic, Milos D, Saxton, Judith A, Snitz, Beth E, Pollen, Daniel A, Moonis, Majaz, Lippa, Carol F, Swearer, Joan M, Johnson, Keith A, Rentz, Dorene M, Fischman, Alan J, Aizenstein, Howard J, DeKosky, Steven T

“…The amyloid cascade hypothesis suggests that the aggregation and deposition of amyloid-beta protein is an initiating event in Alzheimer's disease (AD). Using…”
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Research evaluation and diagnosis of probable Alzheimer's disease over the last two decades : I by LOPEZ, O. L, BECKER, J. T, DEKOSKY, S. T, KLUNK, W, SAXTON, J, HAMILTON, R. L, KAUFER, D. I, SWEET, R. A, MELTZER, C. Cidis, WISNIEWSKI, S, KAMBOH, M. I

“…To describe the experience of a research clinic diagnosing AD during the last two decades, with special emphasis on patients who meet the National Institute of…”
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Reduced binding of Pittsburgh Compound-B in areas of white matter hyperintensities by Goodheart, A E, Tamburo, E, Minhas, D, Aizenstein, H J, McDade, E, Snitz, B E, Price, J C, Mathis, C A, Lopez, O L, Klunk, W E, Cohen, A D

“…The amyloid imaging agent, Pittsburgh Compound-B, binds with high affinity to β-amyloid (Aβ) in the brain, and it is well established that PiB also shows…”
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Accuracy of four clinical diagnostic criteria for the diagnosis of neurodegenerative dementias by LOPEZ, O. L, LITVAN, I, CATT, K. E, STOWE, R, KLUNK, W, KAUFER, D. I, BECKER, J. T, DEKOSKY, S. T

“…To evaluate the inter-rater reliability and validity of clinical diagnostic criteria for neurodegenerative dementias. Inter-rater accuracy of the diagnosis of…”
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Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain by Klunk, William E., Wang, Yanming, Huang, Guo-feng, Debnath, Manik L., Holt, Daniel P., Mathis, Chester A.

“…In vivo assessment of the beta-sheet proteins deposited in amyloid plaques (Aβ peptide) or neurofibrillary tangles (tau protein) presents a target for the…”
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