Search Results - "Klunk, Mariah H."

Adjunct antibody administration with standard treatment reduces relapse rates in a murine tuberculosis model of necrotic granulomas by Ordonez, Alvaro A, Pokkali, Supriya, Kim, Sunhwa, Carr, Brian, Klunk, Mariah H, Tong, Leah, Saini, Vikram, Chang, Yong S, McKevitt, Matthew, Smith, Victoria, Gossage, David L, Jain, Sanjay K

“…Matrix metalloproteinase (MMP)-9 is a zinc-dependent protease associated with early immune responses to Mycobacterium tuberculosis infection, macrophage…”
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Mouse model of pulmonary cavitary tuberculosis and expression of matrix metalloproteinase-9 by Ordonez, Alvaro A, Tasneen, Rokeya, Pokkali, Supriya, Xu, Ziyue, Converse, Paul J, Klunk, Mariah H, Mollura, Daniel J, Nuermberger, Eric L, Jain, Sanjay K

“…Cavitation is a key pathological feature of human tuberculosis (TB), and is a well-recognized risk factor for transmission of infection, relapse after…”
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11C-PABA as a PET Radiotracer for Functional Renal Imaging: Preclinical and First-in-Human Study by Ruiz-Bedoya, Camilo A, Ordonez, Alvaro A, Werner, Rudolf A, Plyku, Donika, Klunk, Mariah H, Leal, Jeff, Lesniak, Wojciech G, Holt, Daniel P, Dannals, Robert F, Higuchi, Takahiro, Rowe, Steven P, Jain, Sanjay K

“…Aminobenzoic acid (PABA) has been previously used as an exogenous marker to verify completion of 24-h urine sampling. Therefore, we hypothesized that PABA…”
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Rabbit model of Staphylococcus aureus implant-associated spinal infection by Gordon, Oren, Miller, Robert J, Thompson, John M, Ordonez, Alvaro A, Klunk, Mariah H, Dikeman, Dustin A, Joyce, Daniel P, Ruiz-Bedoya, Camilo A, Miller, Lloyd S, Jain, Sanjay K

“…Post-surgical implant-associated spinal infection is a devastating complication commonly caused by Biofilm formation is thought to reduce penetration of…”
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Radiosynthesis and PET Bioimaging of 76Br-Bedaquiline in a Murine Model of Tuberculosis by Ordonez, Alvaro A, Carroll, Laurence S, Abhishek, Sudhanshu, Mota, Filipa, Ruiz-Bedoya, Camilo A, Klunk, Mariah H, Singh, Alok K, Freundlich, Joel S, Mease, Ronnie C, Jain, Sanjay K

“…Bedaquiline is a promising drug against tuberculosis (TB), but limited data are available on its intralesional pharmacokinetics. Moreover, current techniques…”
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A Systematic Approach for Developing Bacteria-Specific Imaging Tracers by Ordonez, Alvaro A, Weinstein, Edward A, Bambarger, Lauren E, Saini, Vikram, Chang, Yong S, DeMarco, Vincent P, Klunk, Mariah H, Urbanowski, Michael E, Moulton, Kimberly L, Murawski, Allison M, Pokkali, Supriya, Kalinda, Alvin S, Jain, Sanjay K

“…The modern patient is increasingly susceptible to bacterial infections including those due to multidrug-resistant organisms (MDROs). Noninvasive whole-body…”
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Matrix Metalloproteinase Inhibition in a Murine Model of Cavitary Tuberculosis Paradoxically Worsens Pathology by Ordonez, Alvaro A, Pokkali, Supriya, Sanchez-Bautista, Julian, Klunk, Mariah H, Urbanowski, Michael E, Kübler, André, Bishai, William R, Elkington, Paul T, Jain, Sanjay K

“…Treatment with cipemastat, a selective matrix metalloproteinase inhibitor, paradoxically worsens disease in a mouse model of tuberculosis. Our investigation…”
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11 C-PABA as a PET Radiotracer for Functional Renal Imaging: Preclinical and First-in-Human Study by Ruiz-Bedoya, Camilo A, Ordonez, Alvaro A, Werner, Rudolf A, Plyku, Donika, Klunk, Mariah H, Leal, Jeff, Lesniak, Wojciech G, Holt, Daniel P, Dannals, Robert F, Higuchi, Takahiro, Rowe, Steven P, Jain, Sanjay K

“…Aminobenzoic acid (PABA) has been previously used as an exogenous marker to verify completion of 24-h urine sampling. Therefore, we hypothesized that PABA…”
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Caspase-Based PET for Evaluating Pro-Apoptotic Treatments in a Tuberculosis Mouse Model by Ordonez, Alvaro A., Abhishek, Sudhanshu, Singh, Alok K., Klunk, Mariah H., Azad, Babak Benham, Aboagye, Eric O., Carroll, Laurence, Jain, Sanjay K.

“…Purpose Despite recent advances in antimicrobial treatments, tuberculosis (TB) remains a major global health threat. Mycobacterium tuberculosis proliferates in…”
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Imaging Chronic Tuberculous Lesions Using Sodium [18F]Fluoride Positron Emission Tomography in Mice by Ordonez, Alvaro A., DeMarco, Vincent P., Klunk, Mariah H., Pokkali, Supriya, Jain, Sanjay K.

“…Purpose Calcification is a hallmark of chronic tuberculosis (TB) in humans, often noted years to decades (after the initial infection) on chest radiography,…”
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Imaging Pulmonary Foreign Body Reaction Using [125I]iodo-DPA-713 SPECT/CT in Mice by Sanchez-Bautista, Julian, Foss, Catherine A., Ordonez, Alvaro A., Klunk, Mariah H., Jain, Sanjay K.

“…Purpose Foreign body reactions elicit granulomatous inflammation composed of reactive macrophages. We hypothesized that [ 125 I]iodo-DPA-713 single-photon…”
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Noninvasive 11 C-rifampin positron emission tomography reveals drug biodistribution in tuberculous meningitis by Tucker, Elizabeth W, Guglieri-Lopez, Beatriz, Ordonez, Alvaro A, Ritchie, Brittaney, Klunk, Mariah H, Sharma, Richa, Chang, Yong S, Sanchez-Bautista, Julian, Frey, Sarah, Lodge, Martin A, Rowe, Steven P, Holt, Daniel P, Gobburu, Jogarao V S, Peloquin, Charles A, Mathews, William B, Dannals, Robert F, Pardo, Carlos A, Kannan, Sujatha, Ivaturi, Vijay D, Jain, Sanjay K

“…Tuberculous meningitis (TBM) is a devastating form of tuberculosis (TB), and key TB antimicrobials, including rifampin, have restricted brain penetration. A…”
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Radiosynthesis and Biodistribution of 18 F-Linezolid in Mycobacterium tuberculosis -Infected Mice Using Positron Emission Tomography by Mota, Filipa, Jadhav, Ravindra, Ruiz-Bedoya, Camilo A, Ordonez, Alvaro A, Klunk, Mariah H, Freundlich, Joel S, Jain, Sanjay K

“…Oxazolidinones are a novel class of antibacterials with excellent activity against resistant Gram-positive bacteria including strains causing…”
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Radiosynthesis and Biodistribution of 18F‑Linezolid in Mycobacterium tuberculosis-Infected Mice Using Positron Emission Tomography by Mota, Filipa, Jadhav, Ravindra, Ruiz-Bedoya, Camilo A, Ordonez, Alvaro A, Klunk, Mariah H, Freundlich, Joel S, Jain, Sanjay K

“…Oxazolidinones are a novel class of antibacterials with excellent activity against resistant Gram-positive bacteria including strains causing…”
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Radiosynthesis and PET Bioimaging of 76 Br-Bedaquiline in a Murine Model of Tuberculosis by Ordonez, Alvaro A, Carroll, Laurence S, Abhishek, Sudhanshu, Mota, Filipa, Ruiz-Bedoya, Camilo A, Klunk, Mariah H, Singh, Alok K, Freundlich, Joel S, Mease, Ronnie C, Jain, Sanjay K

“…Bedaquiline is a promising drug against tuberculosis (TB), but limited data are available on its intralesional pharmacokinetics. Moreover, current techniques…”
Get full text