Search Results - "Klunk, Lewis J"

Human radiolabeled mass balance studies: objectives, utilities and limitations by Penner, Natalia, Klunk, Lewis J., Prakash, Chandra

“…The determination of metabolic pathways of a drug candidate through the identification of circulating and excreted metabolites is vitally important to…”
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METABOLISM, PHARMACOKINETICS, AND PROTEIN COVALENT BINDING OF RADIOLABELED MAXIPOST (BMS-204352) IN HUMANS by ZHANG, Donglu, KRISHNA, Rajesh, WANG, Lifei, ZENG, Jianing, MITROKA, James, DAI, Renke, NARASIMHAN, Narayanan, REEVES, Richard A, SRINIVAS, Nuggehally R, KLUNK, Lewis J

“…MaxiPost [(3 S )-(+)-(5-chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2 H -indole-2-one); BMS-204352] is an investigational maxi-K channel…”
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AMIDE N-GLUCURONIDATION OF MAXIPOST CATALYZED BY UDP-GLUCURONOSYLTRANSFERASE 2B7 IN HUMANS by DONGLU ZHANG, WEIPING ZHAO, ROONGTA, Vikram A, MITROKA, James G, KLUNK, Lewis J, MINGSHE ZHU

“…MaxiPost [(3 S )-(+)-(5-chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2 H -indole-2-one), or BMS-204352)] is a potent and specific maxi-K…”
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Drug Metabolites in Safety Testing by Baillie, Thomas A., Cayen, Mitchell N., Fouda, Hassan, Gerson, Ronald J., Green, James D., Grossman, Scott J., Klunk, Lewis J., LeBlanc, Bernard, Perkins, Darcy G., Shipley, Lisa A.

“…This report summarizes the deliberations of a multidisciplinary committee, sponsored by the Pharmaceutical Research and Manufacturers of America, on current…”
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Liquid Chromatography/Chemical Reaction Interface Mass Spectrometry as an Alternative to Radioisotopes for Quantitative Drug Metabolism Studies by Goldthwaite, Charles A, Hsieh, Feng-Yin, Womble, Scott W, Nobes, Brian J, Blair, Ian A, Klunk, Lewis J, Mayol, Robert F

“…Chemical reaction interface mass spectrometry (CRIMS) was coupled on-line with HPLC using a Vestec particle beam interface. A helium-assisted nebulizer…”
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The disposition of 14C-indapamide in man by Klunk, L J, Ringel, S, Neiss, E S

“…The metabolism of 14C-indapamide labeled in the indoline ring was determined after a single oral administration of a solution (4.99 mg, 90.47 microCi) to four…”
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Disposition of conjugate-bound and free doxorubicin in tumor-bearing mice following administration of a BR96-doxorubicin immunoconjugate (BMS 182248) by MOSURE, K. W, HENDERSON, A. J, KLUNK, L. J, KNIPE, J. O

“…The chimeric BR96-doxorubicin (DOX) immunoconjugate, BMS 182248, has induced remissions and cures of human lung adenocarcinoma (L2987) implanted in athymic…”
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Comparative pharmacokinetics of new anti-HIV agents: 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine by Russell, J W, Klunk, L J

“…A number of 2',3'-dideoxynucleosides have been shown to inhibit the in vitro infectivity and cytopathic effect of the human immunodeficiency virus (HIV). These…”
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Gas chromatographic assay for the quantitation of flordipine in human plasma by Klunk, L J, Mangat, S

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Characterization of in vitro metabolites of the antipsychotic drug tiospirone by mass spectrometry by Jajoo, H K, Blair, I A, Klunk, L J, Mayol, R F

“…Metabolism of the antipsychotic drug tiospirone was studied in vitro with phenobarbital-induced rat liver microsomes. Metabolites were isolated and purified to…”
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Multiple forms of rat liver mitochondrial DNA polymerase by Klunk, Jr, L J, Kalf, G F

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REV 2871 (CHBZ): a novel inhibitor of histamine release by Coutts, S M, Khandwala, A, Shoupe, T S, Musser, J H, Klunk, L J, Weinryb, I

“…CHBZ is a novel, non-disodium cromoglycate (DSCG)-like, antiallergic drug in vitro. Whereas DSCG loses antisecretory activity with increasing time of…”
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Determination of 9-[(2-phosphonylmethoxy)ethyl]adenine in rat urine by high-performance liquid chromatography with fluorescence detection by Russell, J W, Marrero, D, Whiterock, V J, Klunk, L J, Starrett, J E

“…A high-performance liquid chromatographic (HPLC) method for the determination of 9-[(2-phosphonylmethoxy)ethyl]adenine (PMEA) in urine is described. The…”
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Biliary excretion and enterohepatic recirculation of methaqualone in the rat by Polk, A, Delong, A F, Smyth, R D, Herczeg, T, Burns, B J, Klunk, Jr, L J, Reavey-Cantwell, N H

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