Search Results - "Klumpp, Susanne"

Reversible phosphorylation of histidine residues in proteins from vertebrates by Klumpp, Susanne, Krieglstein, Josef

“…Signaling by kinases and phosphatases that act on serine, threonine, and tyrosine residues of proteins is among the most extensively studied regulatory…”
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Transforming Growth Factor-β1 Increases Bad Phosphorylation and Protects Neurons Against Damage by Zhu, Yuan, Yang, Guo-Yuan, Ahlemeyer, Barbara, Pang, Li, Che, Xiao-Ming, Culmsee, Carsten, Klumpp, Susanne, Krieglstein, Josef

“…Despite the characterization of neuroprotection by transforming growth factor-β1 (TGF-β1), the signaling pathway mediating its protective effect is unclear…”
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MALDI-TOF high mass calibration up to 200 kDa using human recombinant 16 kDa protein histidine phosphatase aggregates by Ludwig, Katrin, Habbach, Schähdi, Krieglstein, Josef, Klumpp, Susanne, König, Simone

“…Protein histidine phosphatase (PHP) is an enzyme which removes phosphate groups from histidine residues. It was described for vertebrates in the year 2002. The…”
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Damage of Guinea Pig Heart and Arteries by a Trioleate-Enriched Diet and of Cultured Cardiomyocytes by Oleic Acid by Krieglstein, Josef, Kewitz, Tobias, Kirchhefer, Uwe, Hofnagel, Oliver, Weissen-Plenz, Gabriele, Reinbold, Michael, Klumpp, Susanne

“…Background: Mono-unsaturated fatty acids (MUFAs) like oleic acid have been shown to cause apoptosis of cultured endothelial cells by activating protein…”
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Phosphorylation and dephosphorylation of histidine residues in proteins by Klumpp, Susanne, Krieglstein, Josef

“…Protein phosphorylation is a key mechanism for intracellular signal transduction in both prokaryotic and eukaryotic cells. Vertebrate proteins are prevalently…”
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Unsaturated fatty acids liberated from VLDL cause apoptosis in endothelial cells by Reinbold, Michael, Hufnagel, Birgit, Kewitz, Tobias, Klumpp, Susanne, Krieglstein, Josef

“…Certain unsaturated fatty acids (UFAs), cleaved from lipoproteins, are known to activate the serine/threonine protein phosphatase type 2C (PP2C) α- and…”
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ATP-binding on Fibroblast Growth Factor 2 Partially Overlaps with the Heparin-binding Domain by Rose, Karsten, Pallast, Stefanie, Klumpp, Susanne, Krieglstein, Josef

“…Fibroblast growth factor 2 (FGF2), an intensively studied heparin-binding cytokine, is an important modulator of cell growth and differentiation under both…”
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Ginkgolic acids induce neuronal death and activate protein phosphatase type-2C by Ahlemeyer, Barbara, Selke, Dagmar, Schaper, Christine, Klumpp, Susanne, Krieglstein, Josef

“…The standardized extract from Ginkgo biloba (EGb 761) is used for the treatment of dementia. Because of allergenic and genotoxic effects, ginkgolic acids are…”
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Nitric oxide donors induce neurotrophin-like survival signaling and protect neurons against apoptosis by Culmsee, Carsten, Gerling, Norbert, Landshamer, Stefan, Rickerts, Bianca, Duchstein, Hans-Jürgen, Umezawa, Kazuo, Klumpp, Susanne, Krieglstein, Josef

“…Our previous results showed that inhibition of protein tyrosine phosphatases (PTP) by orthovanadate is an appropriate strategy to mimic nerve growth factor…”
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Acetylcholine content and viability of cholinergic neurons are influenced by the activity of protein histidine phosphatase by Eißing, Anna, Fischer, Daniel, Rauch, Ilka, Baumann, Anne, Schebb, Nils-Helge, Karst, Uwe, Rose, Karsten, Klumpp, Susanne, Krieglstein, Josef

“…The first mammalian protein histidine phosphatase (PHP) was discovered in the late 90s of the last century. One of the known substrates of PHP is ATP-citrate…”
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Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants by MacKintosh, Carol, Beattie, Kenneth A., Klumpp, Susanne, Cohen, Philip, Codd, Geoffrey A.

“…The cyclic heptapeptide, microcystin-LR, inhibits protein phosphatases 1 (PP1) and 2A (PP2A) with K i, values below 0.1 nM. Protein phosphatase 2B is inhibited…”
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The tyrosine phosphatase inhibitor orthovanadate mimics NGF-induced neuroprotective signaling in rat hippocampal neurons by Gerling, Norbert, Culmsee, Carsten, Klumpp, Susanne, Krieglstein, Josef

“…Activation of the high affinity neurotrophin receptor tropomyosin-related kinase A (TrkA) by nerve growth factor (NGF) leads to phosphorylation of…”
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An improved procedure for identifying and quantitating protein phosphatases in mammalian tissues by Cohen, Philip, Klumpp, Susanne, Schelling, Donald L.

“…The type 2A protein phosphatases in mammalian tissue extracts are inhibited completely and specifically by 1–2 nM okadaic acid. In contrast, type 1 protein…”
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Protein phosphatase type 2C active at physiological Mg2+: stimulation by unsaturated fatty acids by Klumpp, Susanne, Selke, Dagmar, Hermesmeier, Jan

“…Type 2C serine/threonine protein phosphatases (PP2C) so far require unphysiologically large amounts of Mg2+ ions for activity. Activators and inhibitors are…”
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Dephosphorylation of Centrins by Protein Phosphatase 2C α and β by Thissen, Marie-Christin, Krieglstein, Josef, Wolfrum, Uwe, Klumpp, Susanne

“…In the present study, we identified protein phosphatases dephosphorylating centrins previously phosphorylated by protein kinase CK2. The following phosphatases…”
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Relationship between protein phosphatase type-2C activity and induction of apoptosis in cultured neuronal cells by Klumpp, Susanne, Selke, Dagmar, Ahlemeyer, Barbara, Schaper, Christine, Krieglstein, Josef

“…The cellular composition and concentration of fatty acids are crucial for proliferation and survival. We recently showed stimulation of protein phosphatase…”
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Serine/threonine protein phosphatases in apoptosis by Klumpp, Susanne, Krieglstein, Josef

“…The importance of phosphorylation and dephosphorylation in intracellular signaling pathways has long been recognized, although attention has focused mainly on…”
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Protein histidine [de]phosphorylation in insulin secretion: abnormalities in models of impaired insulin secretion by Kowluru, Anjaneyulu, Klumpp, Susanne, Krieglstein, Josef

“…In the majority of cell types, including the islet β-cell, transduction of extracellular signals involves ligand binding to a receptor, often followed by the…”
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Transforming Growth Factor-beta 1 Increases Bad Phosphorylation and Protects Neurons Against Damage by Zhu, Yuan, Yang, Guo-Yuan, Ahlemeyer, Barbara, Pang, Li, Che, Xiao-Ming, Culmsee, Carsten, Klumpp, Susanne, Krieglstein, Josef

“…Despite the characterization of neuroprotection by transforming growth factor-beta1 (TGF-beta1), the signaling pathway mediating its protective effect is…”
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Reversible phosphorylation of histidine residues in vertebrate proteins by Klumpp, Susanne, Krieglstein, Josef

“…Knowledge on kinases and phosphatases acting on serine, threonine and tyrosine residues of vertebrate proteins is huge. These enzymes are still under intensive…”
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