Search Results - "Klumpp, David J."

Acyloxyacyl hydrolase regulates microglia-mediated pelvic pain by Rahman-Enyart, Afrida, Yaggie, Ryan E, Bollinger, Justin L, Arvanitis, Constadina, Winter, Deborah R, Schaeffer, Anthony J, Klumpp, David J

“…Chronic pelvic pain conditions such as interstitial cystitis/bladder pain syndrome (IC/BPS) remain clinical and mechanistic enigmas. Microglia are resident…”
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AOAH remodels arachidonic acid-containing phospholipid pools in a model of interstitial cystitis pain: A MAPP Network study by Yang, Wenbin, Yaggie, Ryan E, Schaeffer, Anthony J, Klumpp, David J

“…Interstitial cystitis/bladder pain syndrome (IC) is a debilitating condition of chronic pelvic pain with unknown etiology. Recently, we used a genetic approach…”
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Evaluation of the efficacy of a live Escherichia coli biotherapeutic product (asymptomatic bacteriuria E. coli 212) by Segev, Gilad, Chen, Hilla, Dear, Jonathan D., Martínez López, Beatriz, Pires, Jully, Klumpp, David J., Schaeffer, Anthony J., Westropp, Jodi L.

“…Background Recurrent bacterial cystitis, often referred to as recurrent urinary tract infection (UTI), can be difficult to manage and alternative treatments…”
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Urothelial Cultures Support Intracellular Bacterial Community Formation by Uropathogenic Escherichia coli by Berry, Ruth E, Klumpp, David J, Schaeffer, Anthony J

“…Uropathogenic Escherichia coli (UPEC) causes most community-acquired and nosocomial urinary tract infections (UTI). In a mouse model of UTI, UPEC invades…”
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Bacteria-induced uroplakin signaling mediates bladder response to infection by Thumbikat, Praveen, Berry, Ruth E, Zhou, Ge, Billips, Benjamin K, Yaggie, Ryan E, Zaichuk, Tetiana, Sun, Tung-Tien, Schaeffer, Anthony J, Klumpp, David J

“…Urinary tract infections are the second most common infectious disease in humans and are predominantly caused by uropathogenic E. coli (UPEC). A majority of…”
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Mechanisms of pain from urinary tract infection by Rosen, John M, Klumpp, David J

“…:  The pain response to urinary tract infection is largely uncharacterized, but the symptomatic response to urinary tract infection contrasts with the lack of…”
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Animal Models of Urologic Chronic Pelvic Pain Syndromes: Findings From the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network by Lai, Henry, Gereau, Robert W, Luo, Yi, O'Donnell, Michael, Rudick, Charles N, Pontari, Michel, Mullins, Chris, Klumpp, David J

“…Objective To describe the approach taken by the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network investigators to advance the…”
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TRPV1 and the MCP-1/CCR2 Axis Modulate Post-UTI Chronic Pain by Rosen, John M., Yaggie, Ryan E., Woida, Patrick J., Miller, Richard. J., Schaeffer, Anthony J., Klumpp, David J.

“…The etiology of chronic pelvic pain syndromes remains unknown. In a murine urinary tract infection (UTI) model, lipopolysaccharide of uropathogenic E. coli and…”
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Uropathogenic Escherichia coli Induces Chronic Pelvic Pain by Rudick, Charles N, Berry, Ruth E, Johnson, James R, Johnston, Brian, Klumpp, David J, Schaeffer, Anthony J, Thumbikat, Praveen

“…Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a debilitating syndrome of unknown etiology often postulated, but not proven, to be associated…”
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Molecular Basis of Uropathogenic Escherichia coli Evasion of the Innate Immune Response in the Bladder by Billips, Benjamin K, Schaeffer, Anthony J, Klumpp, David J

“…In the urinary tract, the innate immune system detects conserved bacterial components and responds to infection by activating the proinflammatory transcription…”
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Re: Shie et al.: Increased Cell Apoptosis of Urothelium Mediated by Inflammation in Interstitial Cystitis/Painful Bladder Syndrome (Urology 2012;79:484.e7-484.e13) by Klumpp, David J., Ph.D

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Asymptomatic bacteriuria Escherichia coli are live biotherapeutics for UTI by Rudick, Charles N, Taylor, Aisha K, Yaggie, Ryan E, Schaeffer, Anthony J, Klumpp, David J

“…Urinary tract infections (UTI) account for approximately 8 million clinic visits annually with symptoms that include acute pelvic pain, dysuria, and irritative…”
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Mast cell-derived histamine mediates cystitis pain by Rudick, Charles N, Bryce, Paul J, Guichelaar, Laura A, Berry, Ruth E, Klumpp, David J

“…Mast cells trigger inflammation that is associated with local pain, but the mechanisms mediating pain are unclear. Interstitial cystitis (IC) is a bladder…”
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PTP1B deficiency exacerbates inflammation and accelerates leukocyte trafficking in vivo by Berdnikovs, Sergejs, Pavlov, Vladimir I, Abdala-Valencia, Hiam, McCary, Christine A, Klumpp, David J, Tremblay, Michel L, Cook-Mills, Joan M

“…It is reported that PTP1B limits cytokine signaling in vitro. However, PTP1B's function during inflammation in vivo is not known. In this report, we determined…”
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Modulation of Host Innate Immune Response in the Bladder by Uropathogenic Escherichia coli by Billips, Benjamin K, Forrestal, Sarah G, Rycyk, Matthew T, Johnson, James R, Klumpp, David J, Schaeffer, Anthony J

“…Uropathogenic Escherichia coli (UPEC), the most frequent cause of urinary tract infection (UTI), is associated with an inflammatory response which includes the…”
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The differential expression of EphB2 and EphB4 receptor kinases in normal bladder and in transitional cell carcinoma of the bladder by Li, Xiuqing, Choi, Wesley W, Yan, Rui, Yu, Haiyang, Krasnoperov, Valery, Kumar, S Ram, Schuckman, Anne, Klumpp, David J, Pan, Chong-Xian, Quinn, David, Gill, Inderbir S, Gill, Parkash S, Liu, Ren

“…Effective treatment of transitional cell carcinoma (TCC) of the bladder requires early diagnosis. Identifying novel molecular markers in TCC would guide the…”
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Host-Pathogen Interactions Mediating Pain of Urinary Tract Infection by Rudick, Charles N., Billips, Benjamin K., Pavlov, Vladimir I., Yaggie, Ryan E., Schaeffer, Anthony J., Klumpp, David J.

“…Background. Pelvic pain is a major component of the morbidity associated with urinary tract infection (UTI), yet the molecular mechanisms underlying…”
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O-antigen modulates infection-induced pain states by Rudick, Charles N, Jiang, Mingchen, Yaggie, Ryan E, Pavlov, Vladimir I, Done, Joseph, Heckman, Charles J, Whitfield, Christopher, Schaeffer, Anthony J, Klumpp, David J

“…The molecular initiators of infection-associated pain are not understood. We recently found that uropathogenic E. coli (UPEC) elicited acute pelvic pain in…”
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Human Papillomavirus Type 31 E5 Protein Supports Cell Cycle Progression and Activates Late Viral Functions upon Epithelial Differentiation by Fehrmann, Frauke, Klumpp, David J, Laimins, Laimonis A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A Live-Attenuated Vaccine for the Treatment of Urinary Tract Infection by Uropathogenic Escherichia coli by Billips, Benjamin K., Yaggie, Ryan E., Cashy, John P., Schaeffer, Anthony J., Klumpp, David J.

“…Uropathogenic Escherichia coli are the leading cause of urinary tract infection. We recently demonstrated that deletion of the O antigen ligase gene, waaL from…”
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