Search Results - "Klump, Horst H"

Impact of bulge loop size on DNA triplet repeat domains: Implications for DNA repair and expansion by Völker, Jens, Plum, G. Eric, Gindikin, Vera, Klump, Horst H., Breslauer, Kenneth J.

“…ABSTRACT Repetitive DNA sequences exhibit complex structural and energy landscapes, populated by metastable, noncanonical states, that favor expansion and…”
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DNA energy landscapes via calorimetric detection of microstate ensembles of metastable macrostates and triplet repeat diseases by Völker, Jens, Klump, Horst H, Breslauer, Kenneth J

“…Biopolymers exhibit rough energy landscapes, thereby allowing biological processes to access a broad range of kinetic and thermodynamic states. In contrast to…”
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The energetics of i-DNA tetraplex structures formed intermolecularly by d(TC5) and intramolecularly by d[(C5T3)3C5] by Völker, Jens, Klump, Horst H., Breslauer, Kenneth J.

“…Cytosine‐rich DNA at low pH adopts an antiparallel tetraplex structure via the intercalation of two partially protonated, parallel stranded duplexes. This…”
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Energy Landscapes of Dynamic Ensembles of Rolling Triplet Repeat Bulge Loops: Implications for DNA Expansion Associated with Disease States by Völker, Jens, Gindikin, Vera, Klump, Horst H., Plum, G. Eric, Breslauer, Kenneth J.

“…DNA repeat domains can form ensembles of canonical and noncanonical states, including stable and metastable DNA secondary structures. Such sequence-induced…”
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Communication between Noncontacting Macromolecules by Völker, Jens, Klump, Horst H., Breslauer, Kenneth J.

“…We present a quantitative experimental demonstration of solventmediated communication between noncontacting biopolymers. We show that changes in the activity…”
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DNA Repair and DNA Triplet Repeat Expansion: The Impact of Abasic Lesions on Triplet Repeat DNA Energetics by Völker, Jens, Plum, G. Eric, Klump, Horst H, Breslauer, Kenneth J

“…Enhanced levels of DNA triplet expansion are observed when base excision repair (BER) of oxidative DNA base damage (e.g., 8-oxo-dG) occurs at or near CAG…”
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Energy Crosstalk between DNA Lesions: Implications for Allosteric Coupling of DNA Repair and Triplet Repeat Expansion Pathways by Völker, Jens, Plum, G. Eric, Klump, Horst H, Breslauer, Kenneth J

“…Energy coupling between distal DNA domains may have profound regulatory consequences for biological processes, allowing for allosteric control of nucleic acid…”
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Protein thermostability above 100°C: A key role for ionic interactions by Vetriani, Costantino, Maeder, Dennis L., Tolliday, Nicola, Yip, Kitty S.-P., Stillman, Timothy J., Britton, K. Linda, Rice, David W., Klump, Horst H., Robb, Frank T.

“…The discovery of hyperthermophilic microorganisms and the analysis of hyperthermostable enzymes has established the fact that multisubunit enzymes can survive…”
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Length-dependent energetics of (CTG)n and (CAG)n trinucleotide repeats by Amrane, Samir, Saccà, Barbara, Mills, Martin, Chauhan, Madhu, Klump, Horst H., Mergny, Jean-Louis

“…Trinucleotide repeats are involved in a number of debilitating diseases such as myotonic dystrophy. Twelve to seventy-five base-long (CTG)n…”
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DNA Metastability and Biological Regulation:  Conformational Dynamics of Metastable Ω-DNA Bulge Loops by Völker, Jens, Klump, Horst H, Breslauer, Kenneth J

“…Dynamic interchange between DNA conformations, including metastable states, can be of importance to biological function. In this study, we use a combination of…”
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Energetic coupling between clustered lesions modulated by intervening triplet repeat bulge loops: Allosteric implications for DNA repair and triplet repeat expansion by Völker, Jens, Plum, G. Eric, Klump, Horst H., Breslauer, Kenneth J.

“…Clusters of closely spaced oxidative DNA lesions present challenges to the cellular repair machinery. When located in opposing strands, base excision repair…”
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Intercalation into the DNA double helix and in vivo biological activity of water-soluble planar [Pt(diimine)( N, N-dihydroxyethyl- N′-benzoylthioureato)] +Cl − complexes: A study of their thermal stability, their CD spectra and their gel mobility by Wu, Yu-Shan, Koch, Klaus R., Abratt, Valerie R., Klump, Horst H.

“…The interaction of newly synthesised water-soluble planar complexes of general structure [Pt(diimine)( N, N-dihydroxyethyl- N′-benzoylthioureato)] +Cl − with…”
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Restoration of native folding of single-stranded DNA sequences through reverse mutations: An indication of a new epigenetic mechanism by Shepherd, Dionne N., Martin, Darren P., Varsani, Arvind, Thomson, Jennifer A., Rybicki, Edward P., Klump, Horst H.

“…We used in vivo (biological), in silico (computational structure prediction), and in vitro (model sequence folding) analyses of single-stranded DNA sequences…”
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Electrostatic Effects in DNA Triple Helixes by Volker, Jens, Klump, Horst H

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Kinetic and physical characterisation of recombinant wild-type and mutant human protoporphyrinogen oxidases by Maneli, Mbulelo H., Corrigall, Anne V., Klump, Horst H., Davids, Lester M., Kirsch, Ralph E., Meissner, Peter N.

“…The effects of various protoporphyrinogen oxidase (PPOX) mutations responsible for variegate porphyria (VP), the roles of the arginine-59 residue and the…”
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Triple Helical Structures Involving Inosine:  There Is a Penalty for Promiscuity by Mills, Martin, Völker, Jens, Klump, Horst H

“…Inosine has the ability to act as a “wild-card” binding nonspecifically to both A·T and G·C base pairs. This has obvious implications for the design of…”
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Erratum: "Impact of bulge loop size on DNA triplet repeat domains: Implications for DNA repair and expansion" Biopolymers 101(1), 1-12, (2014) by Völker, Jens, Plum, G. Eric, Gindikin, Vera, Klump, Horst H., Breslauer, Kenneth J.

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Energy Landscapes of Triplet Repeat DNA Bulge Loops: Implications for DNA Expansion and Disease States by Völker, Jens, Gindikin, Vera, Klump, Horst H., Plum, G Eric, Breslauer, Kenneth J.

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Protein Thermostability above 100 degrees C: A Key Role for Ionic Interactions by Vetriani, Costantino, Maeder, Dennis L., Tolliday, Nicola, Kitty S.-P. Yip, Stillman, Timothy J., Britton, K. Linda, Rice, David W., Klump, Horst H., Robb, Frank T.

“…The discovery of hyperthermophilic microorganisms and the analysis of hyperthermostable enzymes has established the fact that multisubunit enzymes can survive…”
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Formation of a left-handed RNA double helix: energetics of the A-Z transition of poly[r(G-C)] in concentrated sodium perchlorate solutions by Klump, Horst H, Jovin, Thomas M

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