Search Results - "Klugman, Keith"
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Impact of existing vaccines in reducing antibiotic resistance: Primary and secondary effects
Published in Proceedings of the National Academy of Sciences - PNAS (18-12-2018)“…Vaccines impact antibiotic-resistant infections in two ways: through a direct reduction in the organisms and strains carrying resistant genes that are…”
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COVID-19 pneumonia and the appropriate use of antibiotics
Published in The Lancet global health (01-12-2020)Get full text
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Assessing the Full Burden of Respiratory Syncytial Virus in Young Infants in Low- and Middle-Income Countries: The Importance of Community Mortality Studies
Published in Clinical infectious diseases (02-09-2021)“…Abstract The Bill & Melinda Gates Foundation supported respiratory syncytial virus (RSV) mortality surveillance studies in several low- and middle-income…”
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Access to effective antimicrobials: a worldwide challenge
Published in The Lancet (British edition) (09-01-2016)“…Summary Recent years have seen substantial improvements in life expectancy and access to antimicrobials, especially in low-income and lower-middle-income…”
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Association between respiratory syncytial virus activity and pneumococcal disease in infants: a time series analysis of US hospitalization data
Published in PLoS medicine (01-01-2015)“…The importance of bacterial infections following respiratory syncytial virus (RSV) remains unclear. We evaluated whether variations in RSV epidemic timing and…”
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Respiratory syncytial virus prevention within reach: the vaccine and monoclonal antibody landscape
Published in The Lancet infectious diseases (01-01-2023)“…Respiratory syncytial virus is the second most common cause of infant mortality and a major cause of morbidity and mortality in older adults (aged >60 years)…”
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Prevalence of maternal colonisation with group B streptococcus: a systematic review and meta-analysis
Published in The Lancet infectious diseases (01-09-2016)“…Summary Background The most important risk factor for early-onset (babies younger than 7 days) invasive group B streptococcal disease is rectovaginal…”
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Pneumococcal Capsules and Their Types: Past, Present, and Future
Published in Clinical microbiology reviews (01-07-2015)“…Streptococcus pneumoniae (the pneumococcus) is an important human pathogen. Its virulence is largely due to its polysaccharide capsule, which shields it from…”
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Serotype-specific Cardiac Involvement in Pneumococcal Pneumonia
Published in Clinical infectious diseases (11-02-2022)Get full text
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New respiratory syncytial virus immunization products in low- and middle-income countries: potential for cost-effective impact on a high burden of disease in young infants
Published in BMC medicine (15-05-2023)“…As new, efficacious respiratory syncytial virus (RSV) immunization products reach the market, affordable pricing as well as improved estimation of disease…”
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Maternal influenza immunization and reduced likelihood of prematurity and small for gestational age births: a retrospective cohort study
Published in PLoS medicine (01-05-2011)“…Infections during pregnancy have the potential to adversely impact birth outcomes. We evaluated the association between receipt of inactivated influenza…”
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Usefulness of the Serial Measurement of Vi Antibodies
Published in Clinical infectious diseases (18-06-2018)“…In a secondary analysis of a published immunogenicity trial comparing Vi capsular polysaccharide vaccine with a similar dose (25 µg) conjugated to tetanus…”
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Impact of conjugate pneumococcal vaccines on antibiotic resistance
Published in The Lancet infectious diseases (01-12-2008)“…Summary Reduction of drug-resistant Streptococcus pneumoniae (DRSP) by pneumococcal conjugate vaccines (PCVs) has recently become a reality. We now know that…”
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Effect of 13-valent pneumococcal conjugate vaccine on admissions to hospital 2 years after its introduction in the USA: a time series analysis
Published in The lancet respiratory medicine (01-05-2014)“…Summary Background In March 2010, 13-valent pneumococcal conjugate vaccine (PCV13) replaced the seven-valent vaccine in the USA. We assessed the effect of…”
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Global epidemiology of invasive meningococcal disease
Published in Population health metrics (10-09-2013)“…Neisseria meningitidis is one of the leading causes of bacterial meningitis globally and can also cause sepsis, pneumonia, and other manifestations. In…”
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Time for a third-generation pneumococcal conjugate vaccine
Published in The Lancet infectious diseases (01-01-2021)Get full text
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Triumph of Pneumococcal Conjugate Vaccines: Overcoming a Common Foe
Published in The Journal of infectious diseases (30-09-2021)“…Abstract Pneumococcal conjugate vaccine (PCV) has reduced the burden of pneumococcal disease by the near elimination of vaccine serotypes from countries giving…”
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Antibiotic prophylaxis-Preventing severe infections and saving lives in poor countries with very high mortality risk
Published in PLoS medicine (26-06-2018)“…In a Perspective, Keith P. Klugman and Rasa Izadnegahdar from the Bill and Melinda Gates Foundation discuss the potentials and risks of antibiotic prophylaxis…”
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Antibiotics for paediatric community-acquired pneumonia in resource-constrained settings
Published in The European respiratory journal (01-09-2020)“…Despite Streptococcus pneumoniae and Haemophilus influenzae type b vaccination strategies, pneumonia remains the leading infectious cause of child mortality…”
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Effects of Vaccination on Invasive Pneumococcal Disease in South Africa
Published in The New England journal of medicine (13-11-2014)“…Invasive pneumococcal disease is an important cause of severe illness. In South Africa, a national program to vaccinate children with the conjugated…”
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