Search Results - "Klug, Jason"

Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro by Sarkar, Anindita, Mei, Arianna, Paquola, Apua C.M., Stern, Shani, Bardy, Cedric, Klug, Jason R., Kim, Stacy, Neshat, Neda, Kim, Hyung Joon, Ku, Manching, Shokhirev, Maxim N., Adamowicz, David H., Marchetto, Maria C., Jappelli, Roberto, Erwin, Jennifer A., Padmanabhan, Krishnan, Shtrahman, Matthew, Jin, Xin, Gage, Fred H.

“…Despite widespread interest in using human induced pluripotent stem cells (hiPSCs) in neurological disease modeling, a suitable model system to study human…”
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Genetic-Based Dissection Unveils the Inputs and Outputs of Striatal Patch and Matrix Compartments by Smith, Jared B., Klug, Jason R., Ross, Danica L., Howard, Christopher D., Hollon, Nick G., Ko, Vivian I., Hoffman, Hilary, Callaway, Edward M., Gerfen, Charles R., Jin, Xin

“…The striatum contains neurochemically defined compartments termed patches and matrix. Previous studies suggest patches preferentially receive limbic inputs and…”
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Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure by Amin, Neal D., Bai, Ge, Klug, Jason R., Bonanomi, Dario, Pankratz, Matthew T., Gifford, Wesley D., Hinckley, Christopher A., Sternfeld, Matthew J., Driscoll, Shawn P., Dominguez, Bertha, Lee, Kuo-Fen, Jin, Xin, Pfaff, Samuel L.

“…Dysfunction of microRNA (miRNA) metabolism is thought to underlie diseases affecting motoneurons. One miRNA, miR-218, is abundantly and selectively expressed…”
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Cocaine Experience Controls Bidirectional Synaptic Plasticity in the Nucleus Accumbens by Kourrich, Said, Rothwell, Patrick E, Klug, Jason R, Thomas, Mark J

“…Plasticity of glutamatergic synapses is a fundamental mechanism through which experience changes neural function to impact future behavior. In animal models of…”
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Differential inputs to striatal cholinergic and parvalbumin interneurons imply functional distinctions by Klug, Jason R, Engelhardt, Max D, Cadman, Cara N, Li, Hao, Smith, Jared B, Ayala, Sarah, Williams, Elora W, Hoffman, Hilary, Jin, Xin

“…Striatal cholinergic (ChAT) and parvalbumin (PV) interneurons exert powerful influences on striatal function in health and disease, yet little is known about…”
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Automated Artificial Intelligence Model Trained on a Large Data Set Can Detect Pancreas Cancer on Diagnostic Computed Tomography Scans As Well As Visually Occult Preinvasive Cancer on Prediagnostic Computed Tomography Scans by Korfiatis, Panagiotis, Suman, Garima, Patnam, Nandakumar G, Trivedi, Kamaxi H, Karbhari, Aashna, Mukherjee, Sovanlal, Cook, Cole, Klug, Jason R, Patra, Anurima, Khasawneh, Hala, Rajamohan, Naveen, Fletcher, Joel G, Truty, Mark J, Majumder, Shounak, Bolan, Candice W, Sandrasegaran, Kumar, Chari, Suresh T, Goenka, Ajit H

“…The aims of our case-control study were (1) to develop an automated 3-dimensional (3D) Convolutional Neural Network (CNN) for detection of pancreatic ductal…”
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Association Between Body Composition Measured by Artificial Intelligence and Long-Term Sequelae After Acute Pancreatitis by Cortés, Pedro, Mistretta, Tyler, Jackson, Brittany, Olson, Caroline G., Salih, Ahmed M., Stancampiano, Fernando F., Korfiatis, Panagiotis, Klug, Jason R., Harris, Dana M., Echols, JDan, Carter, Rickey E., Ji, Baoan, Hardway, Heather D., Wallace, Michael B., Kumbhari, Vivek, Bi, Yan

“…Background/Objectives The clinical utility of body composition in the development of complications of acute pancreatitis (AP) remains unclear. We aimed to…”
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GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis by Wills, Tiffany A, Klug, Jason R, Silberman, Yuval, Baucum, Anthony J, Weitlauf, Carl, Colbran, Roger J, Delpire, Eric, Winder, Danny G

“…The bed nucleus of the stria terminalis (BNST) is a critical region for alcohol/drug-induced negative affect and stress-induced reinstatement. NMDA receptor…”
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Clinical Implementation of an Artificial Intelligence Algorithm for Magnetic Resonance–Derived Measurement of Total Kidney Volume by Potretzke, Theodora A., Korfiatis, Panagiotis, Blezek, Daniel J., Edwards, Marie E., Klug, Jason R., Cook, Cole J., Gregory, Adriana V., Harris, Peter C., Chebib, Fouad T., Hogan, Marie C., Torres, Vicente E., Bolan, Candice W., Sandrasegaran, Kumaresan, Kawashima, Akira, Collins, Jeremy D., Takahashi, Naoki, Hartman, Robert P., Williamson, Eric E., King, Bernard F., Callstrom, Matthew R., Erickson, Bradley J., Kline, Timothy L.

“…To evaluate the performance of an internally developed and previously validated artificial intelligence (AI) algorithm for magnetic resonance (MR)–derived…”
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Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability by Klug, Jason R, Mathur, Brian N, Kash, Thomas L, Wang, Hui-Dong, Matthews, Robert T, Robison, A J, Anderson, Mark E, Deutch, Ariel Y, Lovinger, David M, Colbran, Roger J, Winder, Danny G

“…Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is abundant in striatal medium spiny neurons (MSNs). CaMKII is dynamically regulated by changes in…”
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AMPAR-independent effect of striatal αCaMKII promotes the sensitization of cocaine reward by Kourrich, Saïd, Klug, Jason R, Mayford, Mark, Thomas, Mark J

“…Changes in CaMKII-regulated synaptic excitability are a means through which experience may modify neuronal function and shape behavior. While behavior in…”
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Distinct forms of Gq-receptor-dependent plasticity of excitatory transmission in the BNST are differentially affected by stress by McElligott, Zoé A, Klug, Jason R, Nobis, William P, Patel, Sachin, Grueter, Brad A, Kash, Thomas L, Winder, Danny G

“…Long-term depression (LTD) is an important synaptic mechanism for limiting excitatory influence over circuits subserving cognitive and emotional behavior. A…”
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D1 dopamine receptor activation of NFAT-mediated striatal gene expression by Groth, Rachel D., Weick, Jason P., Bradley, Katherine C., Luoma, Jessie I., Aravamudan, Bharathi, Klug, Jason R., Thomas, Mark J., Mermelstein, Paul G.

“…Exposure to drugs of abuse activates gene expression and protein synthesis that result in long‐lasting adaptations in striatal signaling. Therefore,…”
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Comparison of a Deep Learning Model with Human Expert Annotations for Segmentation of Kidneys, Tumors, and Cysts in Routine CT Imaging Exams: FR-PO030 by Kline, Timothy L., Cook, Cole J., Gregory, Adriana, Klug, Jason R., Potretzke, Theodora A., Ron, Eyal, Takahashi, Naoki, Erickson, Bradley J., Khanna, Abhinav, Sharma, Vidit, Leibovich, Bradley

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Prostate Cancer Risk Prediction Model Using Clinical and Magnetic Resonance Imaging–Related Findings: Impact of Combining Lesions' Locations and Apparent Diffusion Coefficient Values by Nakai, Hirotsugu, Takahashi, Hiroaki, LeGout, Jordan D., Kawashima, Akira, Froemming, Adam T., Klug, Jason R., Korfiatis, Panagiotis, Lomas, Derek J., Humphreys, Mitchell R., Dora, Chandler, Takahashi, Naoki

“…Objectives The aims of the study are to develop a prostate cancer risk prediction model that combines clinical and magnetic resonance imaging (MRI)–related…”
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MP30-07 AUTOMATED RENAL VOLUME MEASUREMENT USING ARTIFICIAL INTELLIGENCE: CORRELATION TO POST-OPERATIVE RENAL FUNCTION AFTER RADICAL AND PARTIAL NEPHRECTOMY by Khanna, Abhinav, Sharma, Vidit, Deol, Ekamjit S., Gregory, Adriana, Gottlich, Harrison C., Cook, Cole, Klug, Jason, Lohse, Christine, Potretzke, Theodora, Potretzke, Aaron, Boorjian, Stephen A., Thompson, R. Houston, Rule, Andrew, Takahashi, Naoki, Denic, Alexander, Erickson, Bradley, Kline, Timothy, Leibovich, Bradley

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Volumetric Pancreas Segmentation on Computed Tomography: Accuracy and Efficiency of a Convolutional Neural Network Versus Manual Segmentation in 3D Slicer in the Context of Interreader Variability of Expert Radiologists by Khasawneh, Hala, Patra, Anurima, Rajamohan, Naveen, Suman, Garima, Klug, Jason, Majumder, Shounak, Chari, Suresh T., Korfiatis, Panagiotis, Goenka, Ajit Harishkumar

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Volumetric Pancreas Segmentation on Computed Tomography: Accuracy and Efficiency of a Convolutional Neural Network Versus Manual Segmentation in 3D Slicer in the Context of Interreader Variability of Expert Radiologists by Khasawneh, Hala, Patra, Anurima, Rajamohan, Naveen, Suman, Garima, Klug, Jason, Majumder, Shounak, Chari, Suresh T., Korfiatis, Panagiotis, Goenka, Ajit Harishkumar

“…This study aimed to compare accuracy and efficiency of a convolutional neural network (CNN)-enhanced workflow for pancreas segmentation versus radiologists in…”
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PD08-04 VIRTUAL RENAL MASS BIOPSY: PREDICTING RENAL TUMOR HISTOLOGY ON ABDOMINAL CT IMAGES USING MACHINE LEARNING by Khanna, Abhinav, Sharma, Vidit, Gregory, Adriana, Gottlich, H. Chase, Cook, Cole J., Klug, Jason, Lohse, Christine, Potretzke, Theodora, Potretzke, Aaron, Boorjian, Stephen A., Thompson, R. Houston, Takahashi, Naoki, Erickson, Bradley, Cheville, John, Kline, Timothy, Leibovich, Bradley

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Transition-zone PSA-density calculated from MRI deep learning prostate zonal segmentation model for prediction of clinically significant prostate cancer by Kuanar, Shiba, Cai, Jason, Nakai, Hirotsugu, Nagayama, Hiroki, Takahashi, Hiroaki, LeGout, Jordan, Kawashima, Akira, Froemming, Adam, Mynderse, Lance, Dora, Chandler, Humphreys, Mitchell, Klug, Jason, Korfiatis, Panagiotis, Erickson, Bradley, Takahashi, Naoki

“…Purpose To develop a deep learning (DL) zonal segmentation model of prostate MR from T2-weighted images and evaluate TZ-PSAD for prediction of the presence of…”
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