Search Results - "Klug, Dana M"

Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase by Xie, Stanley C., Wang, Yinuo, Morton, Craig J., Metcalfe, Riley D., Dogovski, Con, Pasaje, Charisse Flerida A., Dunn, Elyse, Luth, Madeline R., Kumpornsin, Krittikorn, Istvan, Eva S., Park, Joon Sung, Fairhurst, Kate J., Ketprasit, Nutpakal, Yeo, Tomas, Yildirim, Okan, Bhebhe, Mathamsanqa N., Klug, Dana M., Rutledge, Peter J., Godoy, Luiz C., Dey, Sumanta, De Souza, Mariana Laureano, Siqueira-Neto, Jair L., Du, Yawei, Puhalovich, Tanya, Amini, Mona, Shami, Gerry, Loesbanluechai, Duangkamon, Nie, Shuai, Williamson, Nicholas, Jana, Gouranga P., Maity, Bikash C., Thomson, Patrick, Foley, Thomas, Tan, Derek S., Niles, Jacquin C., Han, Byung Woo, Goldberg, Daniel E., Burrows, Jeremy, Fidock, David A., Lee, Marcus C. S., Winzeler, Elizabeth A., Griffin, Michael D. W., Todd, Matthew H., Tilley, Leann

“…Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of…”
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Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes by Ferrins, Lori, Buskes, Melissa J, Kapteyn, Madison M, Engels, Hannah N, Enos, Suzanne E, Lu, Chenyang, Klug, Dana M, Singh, Baljinder, Quotadamo, Antonio, Bachovchin, Kelly, Tear, Westley F, Spaulding, Andrew E, Forbes, Katherine C, Bag, Seema, Rivers, Mitch, LeBlanc, Catherine, Burchfield, Erin, Armand, Jeremy R, Diaz-Gonzalez, Rosario, Ceballos-Perez, Gloria, García-Hernández, Raquel, Pérez-Moreno, Guiomar, Bosch-Navarrete, Cristina, Ruiz-Pérez, Luis Miguel, Gamarro, Francisco, González-Pacanowska, Dolores, Navarro, Miguel, Mensa-Wilmot, Kojo, Pollastri, Michael P, Kyle, Dennis E, Rice, Christopher A

“…species, , and are opportunistic pathogens that cause a range of brain, skin, eye, and disseminated diseases in humans and animals. These pathogenic…”
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Open science approaches to COVID-19 [version 1; peer review: 2 approved] by Tse, Edwin G, Klug, Dana M, Todd, Matthew H

“…In only a matter of months, the coronavirus disease of 2019 (COVID-19) has spread around the world. The global impact of the disease has caused significant and…”
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Corrigendum: Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes by Ferrins, Lori, Buskes, Melissa J., Kapteyn, Madison M., Engels, Hannah N., Enos, Suzanne E., Lu, Chenyang, Klug, Dana M., Singh, Baljinder, Quotadamo, Antonio, Bachovchin, Kelly, Tear, Westley F., Spaulding, Andrew E., Forbes, Katherine C., Bag, Seema, Rivers, Mitch, LeBlanc, Catherine, Burchfield, Erin, Armand, Jeremy R., Diaz-Gonzalez, Rosario, Ceballos-Perez, Gloria, García-Hernández, Raquel, Pérez-Moreno, Guiomar, Bosch-Navarrete, Cristina, Gómez-Liñán, Claudia, Ruiz-Pérez, Luis Miguel, Gamarro, Francisco, González-Pacanowska, Dolores, Navarro, Miguel, Mensa-Wilmot, Kojo, Pollastri, Michael P., Kyle, Dennis E., Rice, Christopher A.

“…[This corrects the article DOI: 10.3389/fmicb.2023.1149145.]…”
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There is no market for new antibiotics: this allows an open approach to research and development by Klug, Dana M, Idiris, Fahima I M, Blaskovich, Mark A T, von Delft, Frank, Dowson, Christopher G, Kirchhelle, Claas, Roberts, Adam P, Singer, Andrew C, Todd, Matthew H

“…There is an increasingly urgent need for new antibiotics, yet there is a significant and persistent economic problem when it comes to developing such…”
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Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents by Klug, Dana M, Diaz-Gonzalez, Rosario, Pérez-Moreno, Guiomar, Ceballos-Pérez, Gloria, García-Hernández, Raquel, Gomez-Pérez, Veronica, Ruiz-Pérez, Luis Miguel, Rojas-Barros, Domingo I, Gamarro, Francisco, González-Pacanowska, Dolores, Martínez-Martínez, María S, Manzano, Pilar, Ferrins, Lori, Caffrey, Conor R, Navarro, Miguel, Pollastri, Michael P

“…New treatments are needed for neglected tropical diseases (NTDs) such as Human African trypanosomiasis (HAT), Chagas disease, and schistosomiasis. Through a…”
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Repurposing strategies for tropical disease drug discovery by Klug, Dana M., Gelb, Michael H., Pollastri, Michael P.

“…[Display omitted] Neglected tropical diseases (NTDs) and other diseases of the developing world, such as malaria, attract research investments that are…”
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Engaging the Medicinal Chemists of Tomorrow by Ferrins, Lori, Araujo, Erika, Boudreau, Matthew W, Grenier-Davies, Melissa C, Haranahalli, Krupanandan, Journigan, V Blair, Klug, Dana M, Olson, Margaret E

“…The Young Medicinal Chemists Committee (YMCC) is a part of the larger ACS Division of Medicinal Chemistry (MEDI) and was formed to ensure that MEDI meets the…”
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Hit-to-Lead Optimization of Benzoxazepinoindazoles As Human African Trypanosomiasis Therapeutics by Klug, Dana M, Tschiegg, Laura, Diaz, Rosario, Rojas-Barros, Domingo, Perez-Moreno, Guiomar, Ceballos, Gloria, García-Hernández, Raquel, Martinez-Martinez, Maria Santos, Manzano, Pilar, Ruiz, Luis Miguel, Caffrey, Conor R, Gamarro, Francisco, Pacanowska, Dolores Gonzalez, Ferrins, Lori, Navarro, Miguel, Pollastri, Michael P

“…Human African trypanosomiasis (HAT) is a neglected tropical disease caused by infection with either of two subspecies of the parasite Trypanosoma brucei. Due…”
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Improvement of Aqueous Solubility of Lapatinib-Derived Analogues: Identification of a Quinolinimine Lead for Human African Trypanosomiasis Drug Development by Bachovchin, Kelly A, Sharma, Amrita, Bag, Seema, Klug, Dana M, Schneider, Katherine M, Singh, Baljinder, Jalani, Hitesh B, Buskes, Melissa J, Mehta, Naimee, Tanghe, Scott, Momper, Jeremiah D, Sciotti, Richard J, Rodriguez, Ana, Mensa-Wilmot, Kojo, Pollastri, Michael P, Ferrins, Lori

“…Lapatinib, an approved epidermal growth factor receptor inhibitor, was explored as a starting point for the synthesis of new hits against Trypanosoma brucei,…”
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Lead Optimization of 3,5-Disubstituted-7-Azaindoles for the Treatment of Human African Trypanosomiasis by Klug, Dana M, Mavrogiannaki, Eftychia M, Forbes, Katherine C, Silva, Lisseth, Diaz-Gonzalez, Rosario, Pérez-Moreno, Guiomar, Ceballos-Pérez, Gloria, Garcia-Hernández, Raquel, Bosch-Navarrete, Cristina, Cordón-Obras, Carlos, Gómez-Liñán, Claudia, Saura, Andreu, Momper, Jeremiah D, Martinez-Martinez, Maria Santos, Manzano, Pilar, Syed, Ali, El-Sakkary, Nelly, Caffrey, Conor R, Gamarro, Francisco, Ruiz-Perez, Luis Miguel, Gonzalez Pacanowska, Dolores, Ferrins, Lori, Navarro, Miguel, Pollastri, Michael P

“…Neglected tropical diseases such as human African trypanosomiasis (HAT) are prevalent primarily in tropical climates and among populations living in poverty…”
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Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors by Singh, Baljinder, Bernatchez, Jean A, McCall, Laura-Isobel, Calvet, Claudia M, Ackermann, Jasmin, Souza, Julia M, Thomas, Diane, Silva, Everton M, Bachovchin, Kelly A, Klug, Dana M, Jalani, Hitesh B, Bag, Seema, Buskes, Melissa J, Leed, Susan E, Roncal, Norma E, Penn, Erica C, Erath, Jessey, Rodriguez, Ana, Sciotti, Richard J, Campbell, Robert F, McKerrow, James, Siqueira-Neto, Jair L, Ferrins, Lori, Pollastri, Michael P

“…Utilizing a target repurposing and parasite-hopping approach, we tested a previously reported library of compounds that were active against Trypanosoma brucei,…”
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Open Source Antibiotics: Simple Diarylimidazoles Are Potent against Methicillin-Resistant Staphylococcus aureus by Klug, Dana M, Tse, Edwin G, Silva, Daniel G, Cao, Yafeng, Charman, Susan A, Chauhan, Jyoti, Crighton, Elly, Dichiara, Maria, Drake, Chris, Drewry, David, da Silva Emery, Flavio, Ferrins, Lori, Graves, Lee, Hopkins, Emily, Kresina, Thomas A C, Lorente-Macías, Álvaro, Perry, Benjamin, Phipps, Richard, Quiroga, Bruno, Quotadamo, Antonio, Sabatino, Giada N, Sama, Anthony, Schätzlein, Andreas, Simpson, Quillon J, Steele, Jonathan, Shanu-Wilson, Julia, Sjö, Peter, Stapleton, Paul, Swain, Christopher J, Vaideanu, Alexandra, Xie, Huanxu, Zuercher, William, Todd, Matthew H

“…Antimicrobial resistance (AMR) is widely acknowledged as one of the most serious public health threats facing the world, yet the private sector finds it…”
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Structure–Property Optimization of a Series of Imidazopyridines for Visceral Leishmaniasis by Dichiara, Maria, Simpson, Quillon J., Quotadamo, Antonio, Jalani, Hitesh B., Huang, Anson X., Millard, Caroline C., Klug, Dana M., Tse, Edwin G., Todd, Matthew H., Silva, Daniel Gedder, da Silva Emery, Flavio, Carlson, J. Eric, Zheng, Shao-Liang, Vleminckx, Margot, Matheeussen, An, Caljon, Guy, Pollastri, Michael P., Sjö, Peter, Perry, Benjamin, Ferrins, Lori

“…Leishmaniasis is a collection of diseases caused by more than 20 Leishmania parasite species that manifest as either visceral, cutaneous, or mucocutaneous…”
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Structure–Bioactivity Relationships of Lapatinib Derived Analogs against Schistosoma mansoni by Buskes, Melissa J, Clements, Monica, Bachovchin, Kelly A, Jalani, Hitesh B, Leonard, Allison, Bag, Seema, Klug, Dana M, Singh, Baljinder, Campbell, Robert F, Sciotti, Richard J, El-Sakkary, Nelly, Caffrey, Conor R, Pollastri, Michael P, Ferrins, Lori

“…We recently reported a series of compounds for a solubility-driven optimization campaign of antitrypanosomal compounds. Extending a parasite-hopping approach…”
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Structure-property studies of an imidazoquinoline chemotype with antitrypanosomal activity by Klug, Dana M, Diaz-Gonzalez, Rosario, DeLano, Travis J, Mavrogiannaki, Eftychia M, Buskes, Melissa J, Dalton, Raeann M, Fisher, John K, Schneider, Katherine M, Hilborne, Vivian, Fritsche, Melanie G, Simpson, Quillon J, Tear, Westley F, Devine, William G, Pérez-Moreno, Guiomar, Ceballos-Pérez, Gloria, García-Hernández, Raquel, Bosch-Navarrete, Cristina, Ruiz-Pérez, Luis Miguel, Gamarro, Francisco, González-Pacanowska, Dolores, Martinez-Martinez, Maria Santos, Manzano-Chinchon, Pilar, Navarro, Miguel, Pollastri, Michael P, Ferrins, Lori

“…Human African trypanosomiasis is a neglected tropical disease (NTD) that is fatal if left untreated. Although approximately 13 million people live in moderate-…”
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Hit-to-Lead Optimization of Small Molecules for Neglected Tropical Disease Therapeutics by Klug, Dana M

“…Neglected tropical diseases (NTDs) are a group of twenty diseases defined by the World Health Organization and include indications such as sleeping sickness,…”
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Structure–property studies of an imidazoquinoline chemotype with antitrypanosomal activity† †Electronic supplementary information (ESI) available. See DOI: 10.1039/d0md00103a by Klug, Dana M., Diaz-Gonzalez, Rosario, DeLano, Travis J., Mavrogiannaki, Eftychia M., Buskes, Melissa J., Dalton, Raeann M., Fisher, John K., Schneider, Katherine M., Hilborne, Vivian, Fritsche, Melanie G., Simpson, Quillon J., Tear, Westley F., Devine, William G., Pérez-Moreno, Guiomar, Ceballos-Pérez, Gloria, García-Hernández, Raquel, Bosch-Navarrete, Cristina, Ruiz-Pérez, Luis Miguel, Gamarro, Francisco, González-Pacanowska, Dolores, Martinez-Martinez, Maria Santos, Manzano-Chinchon, Pilar, Navarro, Miguel, Pollastri, Michael P., Ferrins, Lori

“…Structure–property and structure–activity studies identify regions that positively modulate aqueous solubility; though maintaining potent anti-trypanosomal…”
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