Search Results - "Kloxin, April M."

Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties by Kloxin, April M, Kasko, Andrea M, Salinas, Chelsea N, Anseth, Kristi S

“…We report a strategy to create photodegradable poly(ethylene glycol)-based hydrogels through rapid polymerization of cytocompatible macromers for remote…”
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Synthesis of photodegradable hydrogels as dynamically tunable cell culture platforms by Anseth, Kristi S, Kloxin, April M, Tibbitt, Mark W

“…We describe a detailed procedure to create photolabile, polyethylene glycol (PEG)-based hydrogels and manipulate material properties in situ . The…”
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Tuning and Predicting Mesh Size and Protein Release from Step Growth Hydrogels by Rehmann, Matthew S, Skeens, Kelsi M, Kharkar, Prathamesh M, Ford, Eden M, Maverakis, Emanual, Lee, Kelvin H, Kloxin, April M

“…Hydrogel-based depots are of growing interest for release of biopharmaceuticals; however, a priori selection of hydrogel compositions that will retain proteins…”
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Self-Healing Boronic Acid-Based Hydrogels for 3D Co-cultures by Smithmyer, Megan E, Deng, Christopher C, Cassel, Samantha E, LeValley, Paige J, Sumerlin, Brent S, Kloxin, April M

“…Synthetic hydrogels have been widely adopted as well-defined matrices for three-dimensional (3D) cell culture, with increasing interest in systems that enable…”
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Mechanical Properties and Degradation of Chain and Step-Polymerized Photodegradable Hydrogels by Tibbitt, Mark W, Kloxin, April M, Sawicki, Lisa A, Anseth, Kristi S

“…The relationship between polymeric hydrogel microstructure and macroscopic properties is of specific interest to the materials science and polymer science…”
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Chemical Approaches to Dynamically Modulate the Properties of Synthetic Matrices by LeValley, Paige J, Kloxin, April M

“…As knowledge about the dynamic nature of tissues within the human body has increased, the need for cell culture models that mimic the properties of these…”
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Redirecting valvular myofibroblasts into dormant fibroblasts through light-mediated reduction in substrate modulus by Wang, Huan, Haeger, Sarah M, Kloxin, April M, Leinwand, Leslie A, Anseth, Kristi S

“…Fibroblasts residing in connective tissues throughout the body are responsible for extracellular matrix (ECM) homeostasis and repair. In response to tissue…”
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Hierarchically structured hydrogels utilizing multifunctional assembling peptides for 3D cell culture by Hilderbrand, Amber M, Ford, Eden M, Guo, Chen, Sloppy, Jennifer D, Kloxin, April M

“…Approaches for the creation of soft materials, particularly hydrogels, with hierarchical structure are of interest in a variety of applications owing to their…”
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Multiscale Invasion Assay for Probing Macrophage Response to Gram-Negative Bacteria by Wodzanowski, Kimberly A, Caplan, Jeffrey L, Kloxin, April M, Grimes, Catherine L

“…The immune system is a complex network of various cellular components that must differentiate between pathogenic bacteria and the commensal bacteria of the…”
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Dynamic reporters for probing real-time activation of human fibroblasts from single cells to populations by Cassel, Samantha E., Huntington, Breanna M., Chen, Wilfred, Lei, Pedro, Andreadis, Stelios T., Kloxin, April M.

“…Activation of fibroblasts is pivotal for wound healing; however, persistent activation leads to maladaptive processes and is a hallmark of fibrosis, where…”
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Microgels Formed by Spontaneous Click Chemistries Utilizing Microfluidic Flow Focusing for Cargo Release in Response to Endogenous or Exogenous Stimuli by LeValley, Paige J, Parsons, Amanda L, Sutherland, Bryan P, Kiick, Kristi L, Oakey, John S, Kloxin, April M

“…Protein therapeutics have become increasingly popular for the treatment of a variety of diseases owing to their specificity to targets of interest. However,…”
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Designing degradable hydrogels for orthogonal control of cell microenvironments by Kharkar, Prathamesh M, Kiick, Kristi L, Kloxin, April M

“…Degradable and cell-compatible hydrogels can be designed to mimic the physical and biochemical characteristics of native extracellular matrices and provide…”
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Tunable synthetic extracellular matrices to investigate breast cancer response to biophysical and biochemical cues by Sawicki, Lisa A., Ovadia, Elisa M., Pradhan, Lina, Cowart, Julie E., Ross, Karen E., Wu, Cathy H., Kloxin, April M.

“…The extracellular matrix (ECM) is thought to play a critical role in the progression of breast cancer. In this work, we have designed a photopolymerizable,…”
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Fatty acid synthase as a feasible biomarker for triple negative breast cancer stem cell subpopulation cultured on electrospun scaffolds by Rabionet, Marc, Polonio-Alcalá, Emma, Relat, Joana, Yeste, Marc, Sims-Mourtada, Jennifer, Kloxin, April M., Planas, Marta, Feliu, Lidia, Ciurana, Joaquim, Puig, Teresa

“…There is no targeted therapy for triple negative breast cancer (TNBC), which presents an aggressive profile and poor prognosis. Recent studies noticed the…”
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Cell Therapy Biomanufacturing: Integrating Biomaterial and Flow‐Based Membrane Technologies for Production of Engineered T‐Cells by Bomb, Kartik, LeValley, Paige J., Woodward, Ian R., Cassel, Samantha E., Sutherland, Bryan P., Bhattacharjee, Arnab, Yun, Zaining, Steen, Jonathan, Kurdzo, Emily, McCoskey, Jacob, Burris, David, Levine, Kara, Carbrello, Christina, Lenhoff, Abraham M., Fromen, Catherine A., Kloxin, April M.

“…Adoptive T‐cell therapies (ATCTs) are increasingly important for the treatment of cancer, where patient immune cells are engineered to target and eradicate…”
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Photolabile Linkers: Exploiting Labile Bond Chemistry to Control Mode and Rate of Hydrogel Degradation and Protein Release by LeValley, Paige J, Neelarapu, Raghupathi, Sutherland, Bryan P, Dasgupta, Srimoyee, Kloxin, Christopher J, Kloxin, April M

“…Photolabile moieties have been utilized in applications ranging from peptide synthesis and controlled protein activation to tunable and dynamic materials. The…”
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Effects of solvent conditions on the self-assembly of heterotrimeric collagen-like peptide (CLP) triple helices: a coarse-grained simulation study by Taylor, Phillip A, Kronenberger, Stephen, Kloxin, April M, Jayaraman, Arthi

“…We perform coarse-grained (CG) molecular dynamics (MD) simulations to investigate the self-assembly of collagen-like peptide (CLP) triple helices into…”
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On the path to predicting immune responses in the lung: Modeling the pulmonary innate immune system at the air-liquid interface (ALI) by Graf, Jodi, Trautmann-Rodriguez, Michael, Sabnis, Simone, Kloxin, April M., Fromen, Catherine A.

“…Chronic respiratory diseases and infections are among the largest contributors to death globally, many of which still have no cure, including chronic…”
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Impact of collagen-like peptide (CLP) heterotrimeric triple helix design on helical thermal stability and hierarchical assembly: a coarse-grained molecular dynamics simulation study by Taylor, Phillip A, Kloxin, April M, Jayaraman, Arthi

“…Collagen-like peptides (CLP) are multifunctional materials garnering a lot of recent interest from the biomaterials community due to their hierarchical…”
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Bridging 2D and 3D culture: Probing impact of extracellular environment on fibroblast activation in layered hydrogels by Smithmyer, Megan E., Cassel, Samantha E., Kloxin, April M.

“…Many cell behaviors are significantly affected by cell culture geometry, though it remains unclear which geometry from two‐ to three‐dimensional (2D–3D)…”
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