Search Results - "Klotzsche, Anne"

Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis by Weber, Georg F., Chousterman, Benjamin G., He, Shun, Fenn, Ashley M., Nairz, Manfred, Anzai, Atsushi, Brenner, Thorsten, Uhle, Florian, Iwamoto, Yoshiko, Robbins, Clinton S., Noiret, Lorette, Maier, Sarah L., Zönnchen, Tina, Rahbari, Nuh N., Schölch, Sebastian, Klotzsche-von Ameln, Anne, Chavakis, Triantafyllos, Weitz, Jürgen, Hofer, Stefan, Weigand, Markus A., Nahrendorf, Matthias, Weissleder, Ralph, Swirski, Filip K.

“…Sepsis is a frequently fatal condition characterized by an uncontrolled and harmful host reaction to microbial infection. Despite the prevalence and severity…”
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Mechanism of pro-MMP9 activation in co-culture of pro-inflammatory macrophages and cardiomyocytes by Egorov, Dmitry, Kopaliani, Irakli, Ameln, Anne Klotzsche-von, Speier, Stephan, Deussen, Andreas

“…A wide range of cardiac diseases is associated with inflammation. "Inflamed" heart tissue is infiltrated with pro-inflammatory macrophages which extensively…”
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Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance by Chatzigeorgiou, Antonios, Seijkens, Tom, Zarzycka, Barbara, Engel, David, Poggi, Marjorie, van den Berg, Susan, van den Berg, Sjoerd, Soehnlein, Oliver, Winkels, Holger, Beckers, Linda, Lievens, Dirk, Driessen, Ann, Kusters, Pascal, Biessen, Erik, Garcia-Martin, Ruben, Amelna, Anne Klotzsche-von, Gijbels, Marion, Noelle, Randolph, Boon, Louis, Hackeng, Tilman, Schulte, Klaus, Xu, Aimin, Vriend, Gert, Nabuurs, Sander, Chung, Kyoung-Jin, van Dijk, Ko Willems, Rensen, Patrick C. N., Gerdes, Norbert, de Winther, Menno, Block, Norman L., Schally, Andrew V., Webere, Christian, Bornstein, Stefan R., Nicolaes, Gerry, Chavakis, Triantafyllos, Lutgens, Esther

“…The immune system plays an instrumental role in obesity and insulin resistance. Here, we unravel the role of the costimulatory molecule CD40 and its signaling…”
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Developmental endothelial locus-1 modulates platelet-monocyte interactions and instant blood-mediated inflammatory reaction in islet transplantation by Kourtzelis, Ioannis, Kotlabova, Klara, Lim, Jong-Hyung, Mitroulis, Ioannis, Ferreira, Anaisa, Chen, Lan-Sun, Gercken, Bettina, Steffen, Anja, Kemter, Elisabeth, Klotzsche-von Ameln, Anne, Waskow, Claudia, Hosur, Kavita, Chatzigeorgiou, Antonios, Ludwig, Barbara, Wolf, Eckhard, Hajishengallis, George, Chavakis, Triantafyllos

“…Platelet-monocyte interactions are strongly implicated in thrombo-inflammatory injury by actively contributing to intravascular inflammation, leukocyte…”
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Nerve growth factor regulates endothelial cell survival and pathological retinal angiogenesis by Troullinaki, Maria, Alexaki, Vasileia‐Ismini, Mitroulis, Ioannis, Witt, Anke, Klotzsche–von Ameln, Anne, Chung, Kyoung‐Jin, Chavakis, Triantafyllos, Economopoulou, Matina

“…The mechanism underlying vasoproliferative retinopathies like retinopathy of prematurity (ROP) is hypoxia‐triggered neovascularisation. Nerve growth factor…”
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Characterization of tryptophan‐containing dipeptides for anti‐angiogenic effects by Khedr, Sherif, Klotzsche‐von Ameln, Anne, Khedr, Maha, Elsayed, Mohamed H., Sudha, Thangirala, Mousa, Shaker A., Deussen, Andreas, Martin, Melanie

“…Aims In the pathogenesis of several diseases, neo‐angiogenesis is increased (e.g. tumour growth). The peptide L‐glutamyl‐L‐tryptophan (EW/IM862) has been…”
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Endogenous developmental endothelial locus-1 limits ischaemia-related angiogenesis by blocking inflammation by Klotzsche-von Ameln, Anne, Cremer, Sebastian, Hoffmann, Jedrzej, Schuster, Peggy, Khedr, Sherif, Korovina, Irina, Troullinaki, Maria, Neuwirth, Ales, Sprott, David, Chatzigeorgiou, Antonios, Economopoulou, Matina, Orlandi, Alessia, Hain, Andreas, Zeiher, Andreas M, Deussen, Andreas, Hajishengallis, George, Dimmeler, Stefanie, Chavakis, Triantafyllos, Chavakis, Emmanouil

“…We have recently identified endothelial cell-secreted developmental endothelial locus-1 (Del-1) as an endogenous inhibitor of β2-integrin-dependent leukocyte…”
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Endothelial-Specific Deficiency of ATG5 (Autophagy Protein 5) Attenuates Ischemia-Related Angiogenesis by Sprott, David, Poitz, David M, Korovina, Irina, Ziogas, Athanasios, Phieler, Julia, Chatzigeorgiou, Antonios, Mitroulis, Ioannis, Deussen, Andreas, Chavakis, Triantafyllos, Klotzsche-von Ameln, Anne

“…OBJECTIVE—Pathological angiogenesis, such as exuberant retinal neovascularization during proliferative retinopathies, involves endothelial responses to…”
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Proliferative and Survival Effects of PUMA Promote Angiogenesis by Zhang, Fan, Li, Yang, Tang, Zhongshu, Kumar, Anil, Lee, Chunsik, Zhang, Liping, Zhu, Chaoyong, Klotzsche-von Ameln, Anne, Wang, Bin, Gao, Zhiqin, Zhang, Shizhuang, Langer, Harald F., Hou, Xu, Jensen, Lasse, Ma, Wenxin, Wong, Wai, Chavakis, Triantafyllos, Liu, Yizhi, Cao, Yihai, Li, Xuri

“…The p53 upregulated modulator of apoptosis (PUMA) is known as an essential apoptosis inducer. Here, we report the seemingly paradoxical finding that PUMA is a…”
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Hematopoietic hypoxia‐inducible factor 2α deficiency ameliorates pathological retinal neovascularization via modulation of endothelial cell apoptosis by Korovina, Irina, Neuwirth, Ales, Sprott, David, Weber, Silvio, Pasha, Sheik Pran Babu Sardar, Gercken, Bettina, Breier, Georg, El-Armouche, Ali, Deussen, Andreas, Karl, Mike O., Wielockx, Ben, Chavakis, Triantafyllos, Ameln, Anne Klotzsche-von

“…ABSTRACT A hallmark of proliferative retinopathies, such as retinopathy of prematurity (ROP), is a pathological neovascularization orchestrated by hypoxia and…”
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The complement anaphylatoxin C5a receptor contributes to obese adipose tissue inflammation and insulin resistance by Phieler, Julia, Chung, Kyoung-Jin, Chatzigeorgiou, Antonios, Klotzsche-von Ameln, Anne, Garcia-Martin, Ruben, Sprott, David, Moisidou, Maria, Tzanavari, Theodora, Ludwig, Barbara, Baraban, Elena, Ehrhart-Bornstein, Monika, Bornstein, Stefan R, Mziaut, Hassan, Solimena, Michele, Karalis, Katia P, Economopoulou, Matina, Lambris, John D, Chavakis, Triantafyllos

“…Obese adipose tissue (AT) inflammation contributes critically to development of insulin resistance. The complement anaphylatoxin C5a receptor (C5aR) has been…”
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Inhibition of HIF Prolyl Hydroxylase-2 Blocks Tumor Growth in Mice through the Antiproliferative Activity of TGFβ by KLOTZSCHE-VON AMELN, Anne, MUSCHTER, Antje, MAMLOUK, Soulafa, KALUCKA, Joanna, PRADE, Ina, FRANKE, Kristin, REZAEI, Maryam, POITZ, David M, BREIER, Georg, WIELOCKX, Ben

“…Virtually all solid tumors are dependent on a vascular network to provide them with the right amount of nutrients and oxygen. In that sense, low oxygen tension…”
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Endothelial-specific deficiency of Junctional Adhesion Molecule-C promotes vessel normalisation in proliferative retinopathy by Economopoulou, Matina, Avramovic, Nemanja, Klotzsche-von Ameln, Anne, Korovina, Irina, Sprott, David, Samus, Maryna, Gercken, Bettina, Troullinaki, Maria, Grossklaus, Sylvia, Funk, Richard H, Li, Xuri, Imhof, Beat A, Orlova, Valeria V, Chavakis, Triantafyllos

“…In proliferative retinopathies, like proliferative diabetic retinopathy and retinopathy of prematurity (ROP), the hypoxia response is sustained by the failure…”
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Harnessing retinal phagocytes to combat pathological neovascularization in ischemic retinopathies? by Klotzsche-von Ameln, Anne, Sprott, David

“…Ischemic retinopathies (IR) are vision-threatening diseases that affect a substantial amount of people across all age groups worldwide. The current treatment…”
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HIF prolyl hydroxylase-2 inhibition diminishes tumor growth through matrix metalloproteinase-induced TGFβ activation by Klotzsche-von Ameln, Anne, Muschter, Antje, Heimesaat, Markus M., Breier, Georg, Wielockx, Ben

“…A right amount of oxygen and nutrients is essential for a tumor to develop. The role of oxygen dependent pathways and their regulators is therefore of utmost…”
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Myeloid SOCS3 Deficiency Regulates Angiogenesis via Enhanced Apoptotic Endothelial Cell Engulfment by Korovina, Irina, Neuwirth, Ales, Sprott, David, Troullinaki, Maria, Poitz, David M., Deussen, Andreas, Klotzsche-von Ameln, Anne

“…Mononuclear phagocytes, such as macrophages and microglia, are key regulators of organ homeostasis including vascularization processes. Here, we investigated…”
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Dual role of B7 costimulation in obesity‐related nonalcoholic steatohepatitis and metabolic dysregulation by Chatzigeorgiou, Antonios, Chung, Kyoung‐Jin, Garcia‐Martin, Ruben, Alexaki, Vasileia‐Ismini, Klotzsche‐von Ameln, Anne, Phieler, Julia, Sprott, David, Kanczkowski, Waldemar, Tzanavari, Theodora, Bdeir, Mohktar, Bergmann, Sibylle, Cartellieri, Marc, Bachmann, Michael, Nikolakopoulou, Polyxeni, Androutsellis‐Theotokis, Andreas, Siegert, Gabriele, Bornstein, Stefan R., Muders, Michael H., Boon, Louis, Karalis, Katia P., Lutgens, Esther, Chavakis, Triantafyllos

“…The low‐grade inflammatory state present in obesity contributes to obesity‐related metabolic dysregulation, including nonalcoholic steatohepatitis (NASH) and…”
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HIF in vascular development and tumour angiogenesis by Breier, Georg, Licht, Alexander H, Nicolaus, Anke, Klotzsche, Anne, Wielockx, Ben, Kirsnerova, Zuzana

“…Hypoxia stimulates angiogenesis through the up-regulation of vascular endothelial growth factor and other angiogenic cytokines. Members of the…”
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PHD4 stimulates tumor angiogenesis in osteosarcoma cells via TGF-α by Klotzsche-von Ameln, Anne, Prade, Ina, Grosser, Marianne, Kettelhake, Antje, Rezaei, Maryam, Chavakis, Triantafyllos, Flamme, Ingo, Wielockx, Ben, Breier, Georg

“…Solid tumor growth is intimately associated with angiogenesis, a process that is efficiently triggered by hypoxia. Therefore, oxygen-sensitive signaling…”
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Abstract 17597: Endogenous Del-1 is a Negative Regulator of Ischemia-induced Angiogenesis by Interacting With the Leukocytic LFA-1 Integrin by Cremer, Sebastian, Klotzsche-von Ameln, Anne, Orlandi, Alessia, Korovina, Irina, Gercken, Bettina, Zeiher, Andreas M, Dimmeler, Stefanie, Chavakis, Triantafyllos, Chavakis, Emmanouil

“…Abstract only Developmental endothelial locus-1 (Del-1) is an endothelial cell-derived secreted protein circulating in blood and associated with the cell…”
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