Search Results - "Klostergaard, Jim"

Combinatorial Selection of DNA Thioaptamers Targeted to the HA Binding Domain of Human CD44 by Somasunderam, Anoma, Thiviyanathan, Varatharasa, Tanaka, Takemi, Li, Xin, Neerathilingam, Muniasamy, Lokesh, Ganesh Lakshmana Rao, Mann, Aman, Peng, Yang, Ferrari, Mauro, Klostergaard, Jim, Gorenstein, David G

“…CD44, the primary receptor for hyaluronic acid, plays an important role in tumor growth and metastasis. CD44−hyaluronic acid interactions can be exploited for…”
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Hyaluronic Acid- Paclitaxel: Antitumor Efficacy against CD44(+) Human Ovarian Carcinoma Xenografts by Auzenne, Edmond, Ghosh, Sukhen C., Khodadadian, Mojgan, Rivera, Belinda, Farquhar, David, Price, Roger E., Ravoori, Murali, Kundra, Vikas, Freedman, Ralph S., Klostergaard, Jim

“…Numerous human tumor types, including ovarian cancer, display a significant expression of the CD44 family of cell surface proteoglycans. To develop…”
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Magnetic resonance imaging contrast enhancement in vitro and in vivo by octanuclear iron-oxo cluster-based agents by Das, Soma, Parga, Kenia, Chakraborty, Indranil, Tinoco, Arthur D., Delgado, Yamixa, López, Paola M., Fernández Vega, Lauren, Sanakis, Yiannis, Ghosh, Sukhen, Bankson, Jim, Klostergaard, Jim, González-Méndez, Ricardo, Raptis, Raphael G.

“…A water-soluble octanuclear cluster, [Fe8], was studied with regard to its properties as a potential contrast enhancing agent in magnetic resonance imaging…”
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Drug-tolerant cancer cells show reduced tumor-initiating capacity: depletion of CD44 cells and evidence for epigenetic mechanisms by Yan, Hong, Chen, Xin, Zhang, Qiuping, Qin, Jichao, Li, Hangwen, Liu, Can, Calhoun-Davis, Tammy, Coletta, Luis Della, Klostergaard, Jim, Fokt, Izabela, Skora, Stanislaw, Priebe, Waldemar, Bi, Yongyi, Tang, Dean G

“…Cancer stem cells (CSCs) possess high tumor-initiating capacity and have been reported to be resistant to therapeutics. Vice versa, therapy-resistant cancer…”
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Antitumor Activity of Hydrophilic Paclitaxel Copolymer Prodrug Using Locoregional Delivery in Human Orthotopic Non–Small Cell Lung Cancer Xenograft Models by Zou, Yiyu, Fu, Hao, Ghosh, Sukhen, Farquhar, David, Klostergaard, Jim

“…Paclitaxel (Taxol) has demonstrated clinical activity in non–small-cell lung cancer (NSCLC), but its use has not led to marked improvements in survival. This…”
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Superior Therapeutic Profile of Poly-l-Glutamic Acid-Paclitaxel Copolymer Compared with Taxol in Xenogeneic Compartmental Models of Human Ovarian Carcinoma by AUZENNE, Edmond, DONATO, Nicholas J, CHUN LI, LEROUX, Elena, PRICE, Roger E, FARQUHAR, David, KLOSTERGAARD, Jim

“…Previous preclinical studies with ectopic tumor models have demonstrated remarkable improvements in the therapeutic profile of paclitaxel, formulated as a…”
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BRAF Mutations as Actionable Targets: A Paradigm Shift in the Management of Colorectal Cancer and Novel Avenues by Sahin, Ibrahim Halil, Klostergaard, Jim

“…mutations in colorectal cancer have been studied over the past several decades. V600E mutation, a class I mutation, is the most common oncogenic alteration in…”
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Precision medicine for metastatic colorectal cancer: an evolving era by Guler, Irem, Askan, Gokce, Klostergaard, Jim, Sahin, Ibrahim Halil

“…: Metastatic colorectal cancer (CRC) remains a dilemma for cancer researchers with an increasing incidence in the younger patient population. Until the last…”
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Transmembrane TNF (pro-TNF) is palmitoylated by Utsumi, Toshihiko, Takeshige, Tomonori, Tanaka, Kenji, Takami, Kenji, Kira, Yukimi, Klostergaard, Jim, Ishisaka, Rumi

“…Human transmembrane tumor necrosis factor (pro-TNF) was examined for protein acylation. The cDNA encoding pro-TNF was expressed in both COS-1 cells and Sf9…”
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Magnetic nanovectors for drug delivery by Klostergaard, Jim, Seeney, Charles E

“…Abstract Nanotechnology holds the promise of novel and more effective treatments for vexing human health issues. Among these are the use of nanoparticle…”
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CD44: a validated target for improved delivery of cancer therapeutics by Ghosh, Sukhen C, Neslihan Alpay, Sultan, Klostergaard, Jim

“…Advances in cancer therapeutics, namely more effective and less toxic treatments, will occur with targeting strategies that enhance the tumor biodistribution…”
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CD44 as a drug delivery target in human cancers: where are we now? by Sahin, Ibrahim H, Klostergaard, Jim

“…In the treatment of cancers, the dual goals of drug targeting are to deliver therapeutic agents more selectively to tumor tissue and to minimize exposure of…”
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Magnetic nanovectors for drug delivery by Klostergaard, Jim, Seeney, Charles E

“…Abstract Nanotechnology holds the promise of novel and more effective treatments for vexing human health issues. Among these are the use of nanoparticle…”
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Targeting SH2 domains in breast cancer by Morlacchi, Pietro, Robertson, Fredika M, Klostergaard, Jim, McMurray, John S

“…Breast cancer is among the most commonly diagnosed cancer types in women worldwide and is the second leading cause of cancer-related disease in the USA. SH2…”
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TRIB2 contributes to cisplatin resistance in small cell lung cancer by Liang, Yuanxin, Yu, Dong, Perez-Soler, Roman, Klostergaard, Jim, Zou, Yiyu

“…Small cell lung cancer (SCLC) is the most aggressive lung-cancer subtype and so far, no favorable therapeutic strategy has been established for chemo-resistant…”
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Magnetic nanovectors for drug delivery: Nanotechnology: From Fundamental Concepts to Clinical Applications for Healthy Aging by KLOSTERGAARD, Jim, SEENEY, Charles E

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Human pro-tumor necrosis factor: molecular determinants of membrane translocation, sorting, and maturation by Utsumi, Toshihiko, Akimaru, Kunihiro, Kawabata, Zenichiro, Levitan, Alla, Tokunaga, Tetsuhiro, Tang, Ping, Ide, Akio, Hung, Mien-Chie, Klostergaard, Jim

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A Part of the Transmembrane Domain of pro-TNF Can Function as a Cleavable Signal Sequence That Generates a Biologically Active Secretory Form of TNF by Ishisaka, Rumi, Sato, Noriyuki, Tanaka, Kenji, Takeshige, Tomonori, Iwata, Hiroyuki, Klostergaard, Jim, Utsumi, Toshihiko

“…To determine the minimum requirement in the 76-residue leader sequence of pro-tumor necrosis factor (TNF) for membrane translocation across the endoplasmic…”
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Hyaluronic acid–paclitaxel conjugate inhibits growth of human squamous cell carcinomas of the head and neck via a hyaluronic acid-mediated mechanism by Galer, Chad E, Sano, Daisuke, Ghosh, Sukhen C, Hah, Jeong H, Auzenne, Edmund, Hamir, Amirali N, Myers, Jeffrey N, Klostergaard, Jim

“…Summary Chemotherapeutic regimens incorporating taxanes significantly improve outcomes for patients with squamous cell carcinomas of the head and neck (SCCHN)…”
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Magnetically vectored platforms for the targeted delivery of therapeutics to tumors: history and current status by Seeney, Charles, Ojwang, Joshua O, Weiss, Ronald D, Klostergaard, Jim

“…Superparamagnetic iron oxide nanoparticles (SPIONs) are being developed as vehicles for the selective targeting of therapeutics and bioactive compounds…”
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