Search Results - "Kloss, Christian U.A."

Effect of Lipopolysaccharide on the Morphology and Integrin Immunoreactivity of Ramified Microglia in the Mouse Brain and in Cell Culture by Kloss, Christian U.A., Bohatschek, Marion, Kreutzberg, Georg W., Raivich, Gennadij

“…Microglial cells form the first line of defense in brain infection. They are related to monocytes and macrophages and can be readily activated by cell wall…”
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Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function by Raivich, Gennadij, Bohatschek, Marion, Kloss, Christian U.A., Werner, Alexander, Jones, Leonard L., Kreutzberg, Georg W.

“…Damage to the central nervous system (CNS) leads to cellular changes not only in the affected neurons but also in adjacent glial cells and endothelia, and…”
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Interleukin-6 (IL6) and cellular response to facial nerve injury: effects on lymphocyte recruitment, early microglial activation and axonal outgrowth in IL6-deficient mice by Galiano, Matthias, Liu, Zhi Qiang, Kalla, Roger, Bohatschek, Marion, Koppius, Andrea, Gschwendtner, Andreas, Xu, ShengLi, Werner, Alexander, Kloss, Christian U.A., Jones, Leonard L., Bluethmann, Horst, Raivich, Gennadij

“…Nerve injury triggers numerous changes in the injured neurons and surrounding non‐neuronal cells. Of particular interest are molecular signals that play a role…”
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Prolonged cerebral transit time in CADASIL: A transcranial ultrasound study by LIEBETRAU, Martin, HERZOG, Jürgen, KLOSS, Christian U. A, HAMANN, Gerhard F, DICHGANS, Martin

“…Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary angiopathy caused by mutations in Notch3…”
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Immune Surveillance in the Injured Nervous System: T-Lymphocytes Invade the Axotomized Mouse Facial Motor Nucleus and Aggregate around Sites of Neuronal Degeneration by Raivich, Gennadij, Jones, Leonard L, Kloss, Christian U. A, Werner, Alexander, Neumann, Harald, Kreutzberg, Georg W

“…Although the CNS is an established immune-privileged site, it is under surveillance by the immune system, particularly under pathological conditions. In the…”
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Microvascular Basal Lamina Injury After Experimental Focal Cerebral Ischemia and Reperfusion in the Rat by Hamann, Gerhard F., Liebetrau, Martin, Martens, Helge, Burggraf, Dorothe, Kloss, Christian U. A., Bültemeier, Gundula, Wunderlich, Natalie, Jäger, Gabriele, Pfefferkorn, Thomas

“…To define the location and extent of microvascular damage of the basal lamina after cerebral ischemia and reperfusion in rats, the authors subjected animals (n…”
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Microglia and the early phase of immune surveillance in the axotomized facial motor nucleus: Impaired microglial activation and lymphocyte recruitment but no effect on neuronal survival or axonal regeneration in macrophage-colony stimulating factor-deficient mice by Kalla, Roger, Liu, Zhiqiang, Xu, Shengli, Koppius, Andrea, Imai, Yoshinori, Kloss, Christian U.A., Kohsaka, Shinichi, Gschwendtner, Andreas, Möller, J. Carsten, Werner, Alexander, Raivich, Gennadij

“…Activation of microglia is among the first cellular changes in the injured CNS. However, little is known about their specific contribution to secondary damage…”
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In vitro model of microglial deramification: Ramified microglia transform into amoeboid phagocytes following addition of brain cell membranes to microglia-astrocyte cocultures by Bohatschek, Marion, Kloss, Christian U.A., Kalla, Roger, Raivich, Gennadij

“…Changes in the morphology of ramified microglia are a common feature in brain pathology and culminate in the appearance of small, rounded, microglia‐derived…”
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Integrin family of cell adhesion molecules in the injured brain: Regulation and cellular localization in the normal and regenerating mouse facial motor nucleus by Kloss, Christian U.A., Werner, Alexander, Klein, Michael A., Shen, Jun, Menuz, Karen, Probst, J. Chistoph, Kreutzberg, Georg W., Raivich, Gennadij

“…Integrins are a large family of heterodimeric glycoproteins that play a crucial role in cell adhesion during development, inflammation, and tissue repair. In…”
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Loss of microglial ramification in microglia-astrocyte cocultures: Involvement of adenylate cyclase, calcium, phosphatase, and Gi-protein systems by Kalla, Roger, Bohatschek, Marion, Kloss, Christian U.A., Krol, Janna, Von Maltzan, Xenia, Raivich, Gennadij

“…Reduction in microglial branching is a common feature in brain pathology and culminates in the transformation into small, rounded, microglia‐derived phagocytes…”
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Proliferation of ramified microglia on an astrocyte monolayer: Characterization of stimulatory and inhibitory cytokines by Kloss, Christian U.A., Kreutzberg, Georg W., Raivich, Gennadij

“…Proliferation of ramified microglia is a common phenomenon in brain pathology, but little is known about how this is regulated. In the current study, we…”
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Lymphocyte infiltration in the injured brain: Role of proinflammatory cytokines by Raivich, Gennadij, Bohatschek, Marion, Werner, Alexander, Jones, Leonard L., Galiano, Matthias, Kloss, Christian U.A., Zhu, Xing-Zu, Pfeffer, Klaus, Liu, Zhi Qiang

“…Studies using mouse axotomised facial motoneuron model show a strong and highly selective entry of CD3+ lymphocytes into the affected nucleus, with a maximum…”
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Loss of microglial ramification in microglia‐astrocyte cocultures: Involvement of adenylate cyclase, calcium, phosphatase, and G i ‐protein systems by Kalla, Roger, Bohatschek, Marion, Kloss, Christian U.A., Krol, Janna, Von Maltzan, Xenia, Raivich, Gennadij

“…Reduction in microglial branching is a common feature in brain pathology and culminates in the transformation into small, rounded, microglia‐derived phagocytes…”
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Tissue-saving infarct volumetry using histochemistry validated by MRI in rat focal ischemia by Kloss, Christian U.A., Thomassen, Nora, Fesl, Gunther, Helge Martens, K., Yousri, Tarek A., Hamann, Gerhard F.

“…Lesion size is an important outcome parameter in experimental stroke research. However, most methods of measuring the infarct volume in rodents either require…”
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Plasminogen activation in experimental permanent focal cerebral ischemia by Pfefferkorn, Thomas, Wiessner, Christoph, Allegrini, Peter R., Staufer, Brigitte, Vosko, Milan R., Liebetrau, Martin, Bueltemeier, Gundula, Kloss, Christian U.A., Hamann, Gerhard F.

“…Background: Previous experimental work using in situ zymography has shown very early increased plasminogen activation in ischemic regions after 3 h of ischemia…”
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MRI predicts area of increased plasminogen activation in permanent focal cerebral ischemia by Pfefferkorn, Thomas, Wiessner, Christoph, Allegrini, Peter R., Kloss, Christian U.A., Hamann, Gerhard F.

“…To determine if MRI can predict intracerebral plasminogen activation after focal cerebral ischemia (FCI), ischemic regions detected by MRI after 48 h of…”
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