Search Results - "Kloss, C"

Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells by Zhao, Zeguo, Condomines, Maud, van der Stegen, Sjoukje J.C., Perna, Fabiana, Kloss, Christopher C., Gunset, Gertrude, Plotkin, Jason, Sadelain, Michel

“…T cell engineering is a powerful means to rapidly generate anti-tumor T cells. The costimulatory properties of second-generation chimeric antigen receptors…”
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Driving cars to the clinic for solid tumors by Castellarin, Mauro, Watanabe, Keisuke, June, Carl H., Kloss, Christopher C., Posey, Avery D.

“…FDA approval of chimeric antigen receptor T cells (CART cells) is the culmination of several decades of technology development and interrogation of the…”
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International Geomagnetic Reference Field: the thirteenth generation by Alken, P., Thébault, E., Beggan, C. D., Amit, H., Aubert, J., Baerenzung, J., Bondar, T. N., Brown, W. J., Califf, S., Chambodut, A., Chulliat, A., Cox, G. A., Finlay, C. C., Fournier, A., Gillet, N., Grayver, A., Hammer, M. D., Holschneider, M., Huder, L., Hulot, G., Jager, T., Kloss, C., Korte, M., Kuang, W., Kuvshinov, A., Langlais, B., Léger, J.-M., Lesur, V., Livermore, P. W., Lowes, F. J., Macmillan, S., Magnes, W., Mandea, M., Marsal, S., Matzka, J., Metman, M. C., Minami, T., Morschhauser, A., Mound, J. E., Nair, M., Nakano, S., Olsen, N., Pavón-Carrasco, F. J., Petrov, V. G., Ropp, G., Rother, M., Sabaka, T. J., Sanchez, S., Saturnino, D., Schnepf, N. R., Shen, X., Stolle, C., Tangborn, A., Tøffner-Clausen, L., Toh, H., Torta, J. M., Varner, J., Vervelidou, F., Vigneron, P., Wardinski, I., Wicht, J., Woods, A., Yang, Y., Zeren, Z., Zhou, B.

“…In December 2019, the International Association of Geomagnetism and Aeronomy (IAGA) Division V Working Group (V-MOD) adopted the thirteenth generation of the…”
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CD19 CAR-targeted T cells induce long-term remission and B Cell Aplasia in an immunocompetent mouse model of B cell acute lymphoblastic leukemia by Davila, Marco L, Kloss, Christopher C, Gunset, Gertrude, Sadelain, Michel

“…Although many adults with B cell acute lymphoblastic leukemia (B-ALL) are induced into remission, most will relapse, underscoring the dire need for novel…”
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Localized Origin at the Core‐Mantle Boundary of the 1969 Geomagnetic Impulse by Blangsbøll, R. M., Finlay, C. C., Kloss, C.

“…The 1969 geomagnetic impulse provided the first compelling evidence for rapid changes in Earth's core‐generated magnetic field, taking place on timescales of a…”
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Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF by Ramalingam, Pradeep, Poulos, Michael G., Lazzari, Elisa, Gutkin, Michael C., Lopez, David, Kloss, Christopher C., Crowley, Michael J., Katsnelson, Lizabeth, Freire, Ana G., Greenblatt, Matthew B., Park, Christopher Y., Butler, Jason M.

“…Inflammatory signals arising from the microenvironment have emerged as critical regulators of hematopoietic stem cell (HSC) function during diverse processes…”
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The unexpected radiative impact of the Hunga Tonga eruption of 15th January 2022 by Sellitto, P., Podglajen, A., Belhadji, R., Boichu, M., Carboni, E., Cuesta, J., Duchamp, C., Kloss, C., Siddans, R., Bègue, N., Blarel, L., Jegou, F., Khaykin, S., Renard, J. -B., Legras, B.

“…Abstract The underwater Hunga Tonga-Hunga Ha-apai volcano erupted in the early hours of 15th January 2022, and injected volcanic gases and aerosols to over 50…”
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Activation of the vascular niche supports leukemic progression and resistance to chemotherapy by Poulos, Michael G, Gars, Eric J, Gutkin, Michael C, Kloss, Christopher C, Ginsberg, Michael, Scandura, Joseph M, Rafii, Shahin, Butler, Jason M

“…Understanding the intricate cellular components of the bone marrow microenvironment can lead to the discovery of novel extrinsic factors that are responsible…”
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Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition by Rafii, Shahin, Kloss, Christopher C., Butler, Jason M., Ginsberg, Michael, Gars, Eric, Lis, Raphael, Zhan, Qiansheng, Josipovic, Pavle, Ding, Bi-Sen, Xiang, Jenny, Elemento, Olivier, Zaninovic, Nikica, Rosenwaks, Zev, Sadelain, Michel, Rafii, Jeremie A., James, Daylon

“…Several studies have demonstrated that hematopoietic cells originate from endothelium in early development; however, the phenotypic progression of progenitor…”
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Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration by Wertheimer, Tobias, Velardi, Enrico, Tsai, Jennifer, Cooper, Kirsten, Xiao, Shiyun, Kloss, Christopher C, Ottmüller, Katja J, Mokhtari, Zeinab, Brede, Christian, deRoos, Paul, Kinsella, Sinéad, Palikuqi, Brisa, Ginsberg, Michael, Young, Lauren F, Kreines, Fabiana, Lieberman, Sophia R, Lazrak, Amina, Guo, Peipei, Malard, Florent, Smith, Odette M, Shono, Yusuke, Jenq, Robert R, Hanash, Alan M, Nolan, Daniel J, Butler, Jason M, Beilhack, Andreas, Manley, Nancy R, Rafii, Shahin, Dudakov, Jarrod A, van den Brink, Marcel R M

“…The thymus is not only extremely sensitive to damage but also has a remarkable ability to repair itself. However, the mechanisms underlying this endogenous…”
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Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells by Kloss, Christopher C, Condomines, Maud, Cartellieri, Marc, Bachmann, Michael, Sadelain, Michel

“…To increase the tumor specificity of engineered T cells, Kloss et al . design an approach that relies on T cell recognition of two, rather than one, antigens…”
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Simulating coarse particle conveying by a set of Eulerian, Lagrangian and hybrid particle models by Pirker, S., Kahrimanovic, D., Kloss, C., Popoff, B., Braun, M.

“…This paper considers the behaviour of mono-disperse coarse glass particles in a pneumatic conveying experiment which consists of a curved and straight…”
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Application of a hybrid Lattice Boltzmann–Finite Volume turbulence model to cyclone short-cut flow by Pirker, S., Goniva, C., Kloss, C., Puttinger, S., Houben, J., Schneiderbauer, S.

“…This paper introduces a hybrid turbulence model for studying the phenomenon of cyclone short-cut flow: While the global flow situation comprising inflow,…”
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Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication by Kloss, Christopher C., Lee, Jihyun, Zhang, Aaron, Chen, Fang, Melenhorst, Jan Joseph, Lacey, Simon F., Maus, Marcela V., Fraietta, Joseph A., Zhao, Yangbing, June, Carl H.

“…Cancer has an impressive ability to evolve multiple processes to evade therapies. While immunotherapies and vaccines have shown great promise, particularly in…”
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Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy by Themeli, Maria, Kloss, Christopher C, Ciriello, Giovanni, Fedorov, Victor D, Perna, Fabiana, Gonen, Mithat, Sadelain, Michel

“…T cells generated from human iPSCs engineered to express a chimeric antigen receptor display innate lymphoid properties and inhibit tumor growth in mice…”
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A large-scale study of differential gene expression in monocyte-derived macrophages infected with several strains of Mycobacterium avium subspecies paratuberculosis by Kabara, Edward, Kloss, Christopher C, Wilson, Melind, Tempelman, Robert J, Sreevatsan, Srinand, Janagama, Harish, Coussens, Paul M

“…Mycobacterium avium subspecies paratuberculosis (MAP) is a significant concern to the American and European dairy industries and possibly to human health. MAP…”
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PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial by Narayan, Vivek, Barber-Rotenberg, Julie S., Jung, In-Young, Lacey, Simon F., Rech, Andrew J., Davis, Megan M., Hwang, Wei-Ting, Lal, Priti, Carpenter, Erica L., Maude, Shannon L., Plesa, Gabriela, Vapiwala, Neha, Chew, Anne, Moniak, Michael, Sebro, Ronnie A., Farwell, Michael D., Marshall, Amy, Gilmore, Joan, Lledo, Lester, Dengel, Karen, Church, Sarah E., Hether, Tyler D., Xu, Jun, Gohil, Mercy, Buckingham, Thomas H., Yee, Stephanie S., Gonzalez, Vanessa E., Kulikovskaya, Irina, Chen, Fang, Tian, Lifeng, Tien, Kyle, Gladney, Whitney, Nobles, Christopher L., Raymond, Hayley E., Hexner, Elizabeth O., Siegel, Donald L., Bushman, Frederic D., June, Carl H., Fraietta, Joseph A., Haas, Naomi B.

“…Chimeric antigen receptor (CAR) T cells have demonstrated promising efficacy, particularly in hematologic malignancies. One challenge regarding CAR T cells in…”
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2001 Mars Odyssey Mission Summary by Saunders, R S, Arvidson, R E, Badhwar, G D, Boynton, W V, Christensen, PR, Cucinotta, F A, Feldman, W C, Gibbs, R G, Kloss, C, Landano, M R, Mase, R A, McSmith, G W, Meyer, MA, Mitrofanov, I G, Pace, G D, Plaut, J J, Sidney, W P, Spencer, DA, Thompson, T W, Zeitlin, C J

“…The 2001 Mars Odyssey spacecraft, now in orbit at Mars, will observe the Martian surface at infrared and visible wavelengths to determine surface mineralogy…”
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Prevalence of fractures in women with intellectual disabilities: a chart review by Schrager, S., Kloss, C., Ju, A. W.

“…Background  Numerous studies have demonstrated high rates of osteoporosis and fractures in women with intellectual disabilities (IDs). All of the studies use…”
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Cytotoxic Potential of Proinflammatory Cytokines: Combined Deletion of TNF Receptors TNFR1 and TNFR2 Prevents Motoneuron Cell Death after Facial Axotomy in Adult Mouse by Raivich, G., Liu, Z.Q., Kloss, C.U.A., Labow, M., Bluethmann, H., Bohatschek, M.

“…Neural injury is known to trigger inflammatory changes, including the synthesis of proinflammatory cytokines such as interleukin-1-beta (IL1β), tumor necrosis…”
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