Search Results - "Klose, Robert J"

Understanding the relationship between DNA methylation and histone lysine methylation by Rose, Nathan R., Klose, Robert J.

“…DNA methylation acts as an epigenetic modification in vertebrate DNA. Recently it has become clear that the DNA and histone lysine methylation systems are…”
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Live-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy by Huseyin, Miles K., Klose, Robert J.

“…Polycomb repressive complex 1 (PRC1) is an essential chromatin-based repressor of gene transcription. How PRC1 engages with chromatin to identify its target…”
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Regulation of histone methylation by demethylimination and demethylation by Zhang, Yi, Klose, Robert J

“…Histone methylation has important roles in regulating transcription, genome integrity and epigenetic inheritance. Historically, methylated histone arginine and…”
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The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells by King, Hamish W, Klose, Robert J

“…Pioneer transcription factors recognise and bind their target sequences in inaccessible chromatin to establish new transcriptional networks throughout…”
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PRC1 Catalytic Activity Is Central to Polycomb System Function by Blackledge, Neil P., Fursova, Nadezda A., Kelley, Jessica R., Huseyin, Miles K., Feldmann, Angelika, Klose, Robert J.

“…The Polycomb repressive system is an essential chromatin-based regulator of gene expression. Despite being extensively studied, how the Polycomb system selects…”
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Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression by Fursova, Nadezda A., Blackledge, Neil P., Nakayama, Manabu, Ito, Shinsuke, Koseki, Yoko, Farcas, Anca M., King, Hamish W., Koseki, Haruhiko, Klose, Robert J.

“…The Polycomb system modifies chromatin and plays an essential role in repressing gene expression to control normal mammalian development. However, the…”
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ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection by Long, Hannah K, Blackledge, Neil P, Klose, Robert J

“…Vertebrate DNA can be chemically modified by methylation of the 5 position of the cytosine base in the context of CpG dinucleotides. This modification creates…”
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JmjC-domain-containing proteins and histone demethylation by Zhang, Yi, Klose, Robert J, Kallin, Eric M

“…Histone methylation has important roles in regulating gene expression and forms part of the epigenetic memory system that regulates cell fate and identity…”
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Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation by Blackledge, Neil P, Farcas, Anca M, Kondo, Takashi, King, Hamish W, McGouran, Joanna F, Hanssen, Lars L P, Ito, Shinsuke, Cooper, Sarah, Kondo, Kaori, Koseki, Yoko, Ishikura, Tomoyuki, Long, Hannah K, Sheahan, Thomas W, Brockdorff, Neil, Kessler, Benedikt M, Koseki, Haruhiko, Klose, Robert J

“…Chromatin modifying activities inherent to polycomb repressive complexes PRC1 and PRC2 play an essential role in gene regulation, cellular differentiation, and…”
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Genomic DNA methylation: the mark and its mediators by Klose, Robert J., Bird, Adrian P.

“…Methylation of DNA at position five of the cytosine ring occurs at most CpG dinucleotides in the mammalian genome and is essential for embryonic viability…”
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A CpG island-encoded mechanism protects genes from premature transcription termination by Hughes, Amy L., Szczurek, Aleksander T., Kelley, Jessica R., Lastuvkova, Anna, Turberfield, Anne H., Dimitrova, Emilia, Blackledge, Neil P., Klose, Robert J.

“…Transcription must be tightly controlled to regulate gene expression and development. However, our understanding of the molecular mechanisms that influence…”
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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases by Chowdhury, Rasheduzzaman, Yeoh, Kar Kheng, Tian, Ya-Min, Hillringhaus, Lars, Bagg, Eleanor A, Rose, Nathan R, Leung, Ivanhoe K H, Li, Xuan S, Woon, Esther C Y, Yang, Ming, McDonough, Michael A, King, Oliver N, Clifton, Ian J, Klose, Robert J, Claridge, Timothy D W, Ratcliffe, Peter J, Schofield, Christopher J, Kawamura, Akane

“…Mutations in isocitrate dehydrogenases (IDHs) have a gain‐of‐function effect leading to R (−)‐2‐hydroxyglutarate ( R‐ 2HG) accumulation. By using biochemical,…”
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Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells by Rhodes, James D.P., Feldmann, Angelika, Hernández-Rodríguez, Benjamín, Díaz, Noelia, Brown, Jill M., Fursova, Nadezda A., Blackledge, Neil P., Prathapan, Praveen, Dobrinic, Paula, Huseyin, Miles K., Szczurek, Aleksander, Kruse, Kai, Nasmyth, Kim A., Buckle, Veronica J., Vaquerizas, Juan M., Klose, Robert J.

“…How chromosome organization is related to genome function remains poorly understood. Cohesin, loop extrusion, and CCCTC-binding factor (CTCF) have been…”
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Protection of CpG islands from DNA methylation is DNA-encoded and evolutionarily conserved by Long, Hannah K, King, Hamish W, Patient, Roger K, Odom, Duncan T, Klose, Robert J

“…DNA methylation is a repressive epigenetic modification that covers vertebrate genomes. Regions known as CpG islands (CGIs), which are refractory to DNA…”
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The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36 by Wong, Jiemin, Klose, Robert J, Tempst, Paul, Yamane, Kenichi, Bae, Yangjin, Zhang, Yi, Zhang, Dianzheng, Erdjument-Bromage, Hediye

“…Post-translational modification of chromatin has profound effects on many biological processes including transcriptional regulation, heterochromatin…”
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Chromatin sampling--an emerging perspective on targeting polycomb repressor proteins by Klose, Robert J, Cooper, Sarah, Farcas, Anca M, Blackledge, Neil P, Brockdorff, Neil

“…  Association of additional subunits with noncanonical PRC1 occurs in a manner dependent on the associated PCGF protein. [...]PCGF1 complexes, discussed…”
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Extensive DNA methylome rearrangement during early lamprey embryogenesis by Angeloni, Allegra, Fissette, Skye, Kaya, Deniz, Hammond, Jillian M., Gamaarachchi, Hasindu, Deveson, Ira W., Klose, Robert J., Li, Weiming, Zhang, Xiaotian, Bogdanovic, Ozren

“…DNA methylation (5mC) is a repressive gene regulatory mark widespread in vertebrate genomes, yet the developmental dynamics in which 5mC patterns are…”
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KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands by Farcas, Anca M, Blackledge, Neil P, Sudbery, Ian, Long, Hannah K, McGouran, Joanna F, Rose, Nathan R, Lee, Sheena, Sims, David, Cerase, Andrea, Sheahan, Thomas W, Koseki, Haruhiko, Brockdorff, Neil, Ponting, Chris P, Kessler, Benedikt M, Klose, Robert J

“…CpG islands (CGIs) are associated with most mammalian gene promoters. A subset of CGIs act as polycomb response elements (PREs) and are recognized by the…”
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Analysis of Genome Architecture during SCNT Reveals a Role of Cohesin in Impeding Minor ZGA by Zhang, Ke, Wu, Dan-Ya, Zheng, Hui, Wang, Yao, Sun, Qiao-Ran, Liu, Xin, Wang, Li-Yan, Xiong, Wen-Jing, Wang, Qiujun, Rhodes, James D.P., Xu, Kai, Li, Lijia, Lin, Zili, Yu, Guang, Xia, Weikun, Huang, Bo, Du, Zhenhai, Yao, Yao, Nasmyth, Kim A., Klose, Robert J., Miao, Yi-Liang, Xie, Wei

“…Somatic cell nuclear transfer (SCNT) can reprogram a somatic nucleus to a totipotent state. However, the re-organization of 3D chromatin structure in this…”
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Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes by Sugishita, Hiroki, Kondo, Takashi, Ito, Shinsuke, Nakayama, Manabu, Yakushiji-Kaminatsui, Nayuta, Kawakami, Eiryo, Koseki, Yoko, Ohinata, Yasuhide, Sharif, Jafar, Harachi, Mio, Blackledge, Neil P., Klose, Robert J., Koseki, Haruhiko

“…Polycomb repressive complexes-1 and -2 (PRC1 and 2) silence developmental genes in a spatiotemporal manner during embryogenesis. How Polycomb group (PcG)…”
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