Search Results - "Klose, Franziska"

Cladribine treatment specifically affects peripheral blood memory B cell clones and clonal expansion in multiple sclerosis patients by Ruschil, Christoph, Gabernet, Gisela, Kemmerer, Constanze Louisa, Jarboui, Mohamed Ali, Klose, Franziska, Poli, Sven, Ziemann, Ulf, Nahnsen, Sven, Kowarik, Markus Christian

“…B cells are acknowledged as crucial players in the pathogenesis of multiple sclerosis (MS). Several disease modifying drugs including cladribine have been…”
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A Multi-Omics Approach Identifies Key Regulatory Pathways Induced by Long-Term Zinc Supplementation in Human Primary Retinal Pigment Epithelium by Emri, Eszter, Kortvely, Elod, Dammeier, Sascha, Klose, Franziska, Simpson, David, Consortium, Eye-Risk, Den Hollander, Anneke I, Ueffing, Marius, Lengyel, Imre

“…In age-related macular degeneration (AMD), both systemic and local zinc levels decline. Elevation of zinc in clinical studies delayed the progression to…”
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Paralog-specific TTC30 regulation of Sonic hedgehog signaling by Hoffmann, Felix, Bolz, Sylvia, Junger, Katrin, Klose, Franziska, Stehle, Isabel F, Ueffing, Marius, Boldt, Karsten, Beyer, Tina

“…The intraflagellar transport (IFT) machinery is essential for cilia assembly, maintenance, and trans-localization of signaling proteins. The IFT machinery…”
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Human Dopaminergic Neurons Lacking PINK1 Exhibit Disrupted Dopamine Metabolism Related to Vitamin B6 Co-Factors by Bus, Christine, Zizmare, Laimdota, Feldkaemper, Marita, Geisler, Sven, Zarani, Maria, Schaedler, Anna, Klose, Franziska, Admard, Jakob, Mageean, Craig J., Arena, Giuseppe, Fallier-Becker, Petra, Ugun-Klusek, Aslihan, Maruszczak, Klaudia K., Kapolou, Konstantina, Schmid, Benjamin, Rapaport, Doron, Ueffing, Marius, Casadei, Nicolas, Krüger, Rejko, Gasser, Thomas, Vogt Weisenhorn, Daniela M., Kahle, Philipp J., Trautwein, Christoph, Gloeckner, Christian J., Fitzgerald, Julia C.

“…PINK1 loss-of-function mutations cause early onset Parkinson disease. PINK1-Parkin mediated mitophagy has been well studied, but the relevance of the…”
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Tissue- and isoform-specific protein complex analysis with natively processed bait proteins by Beyer, Tina, Klose, Franziska, Kuret, Anna, Hoffmann, Felix, Lukowski, Robert, Ueffing, Marius, Boldt, Karsten

“…Protein-protein interaction analysis is an important tool to elucidate the function of proteins and protein complexes as well as their dynamic behavior. To…”
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Interactome Analysis Reveals a Link of the Novel ALMS1-CEP70 Complex to Centrosomal Clusters by Woerz, Franziska, Hoffmann, Felix, Antony, Shibu, Bolz, Sylvia, Jarboui, Mohamed Ali, Junger, Katrin, Klose, Franziska, Stehle, Isabel F., Boldt, Karsten, Ueffing, Marius, Beyer, Tina

“…Alström syndrome (ALMS) is a very rare autosomal-recessive disorder, causing a broad range of clinical defects most notably retinal degeneration, type 2…”
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An organelle-specific protein landscape identifies novel diseases and molecular mechanisms by Boldt, Karsten, van Reeuwijk, Jeroen, Lu, Qianhao, Koutroumpas, Konstantinos, Nguyen, Thanh-Minh T., Texier, Yves, van Beersum, Sylvia E. C., Horn, Nicola, Willer, Jason R., Mans, Dorus A., Dougherty, Gerard, Lamers, Ideke J. C., Coene, Karlien L. M., Arts, Heleen H., Betts, Matthew J., Beyer, Tina, Bolat, Emine, Gloeckner, Christian Johannes, Haidari, Khatera, Hetterschijt, Lisette, Iaconis, Daniela, Jenkins, Dagan, Klose, Franziska, Knapp, Barbara, Latour, Brooke, Letteboer, Stef J. F., Marcelis, Carlo L., Mitic, Dragana, Morleo, Manuela, Oud, Machteld M., Riemersma, Moniek, Rix, Susan, Terhal, Paulien A., Toedt, Grischa, van Dam, Teunis J. P., de Vrieze, Erik, Wissinger, Yasmin, Wu, Ka Man, Apic, Gordana, Beales, Philip L., Blacque, Oliver E., Gibson, Toby J., Huynen, Martijn A., Katsanis, Nicholas, Kremer, Hannie, Omran, Heymut, van Wijk, Erwin, Wolfrum, Uwe, Kepes, François, Davis, Erica E., Franco, Brunella, Giles, Rachel H., Ueffing, Marius, Russell, Robert B., Roepman, Ronald

“…Cellular organelles provide opportunities to relate biological mechanisms to disease. Here we use affinity proteomics, genetics and cell biology to interrogate…”
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Corrigendum to “Tissue- and isoform-specific protein complex analysis with natively processed bait proteins” [Journal of Proteomics, Volume 231 (2021), Article 103947] by Beyer, Tina, Klose, Franziska, Kuret, Anna, Hoffmann, Felix, Lukowski, Robert, Ueffing, Marius, Boldt, Karsten

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Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation by Scholz, Nicole, Dahse, Anne-Kristin, Kemkemer, Marguerite, Bormann, Anne, Auger, Genevieve M., Vieira Contreras, Fernando, Ernst, Lucia F., Staake, Hauke, Körner, Marek B., Buhlan, Max, Meyer-Mölck, Amelie, Chung, Yin Kwan, Blanco-Redondo, Beatriz, Klose, Franziska, Jarboui, Mohamed Ali, Ljaschenko, Dmitrij, Bigl, Marina, Langenhan, Tobias

“…Adhesion G-protein-coupled receptors (aGPCRs) bear notable similarity to Notch proteins 1 , a class of surface receptors poised for mechano-proteolytic…”
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Proteasuria in nephrotic syndrome–quantification and proteomic profiling by Wörn, Matthias, Bohnert, Bernhard N., Alenazi, Fawza, Boldt, Karsten, Klose, Franziska, Junger, Katrin, Ueffing, Marius, Birkenfeld, Andreas L., Kalbacher, Hubert, Artunc, Ferruh

“…Nephrotic syndrome is characterized by urinary excretion of plasma proteases or proteasuria. There is a lack of data on the quantity, activity status and…”
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TTC30A and TTC30B Redundancy Protects IFT Complex B Integrity and Its Pivotal Role in Ciliogenesis by Hoffmann, Felix, Bolz, Sylvia, Junger, Katrin, Klose, Franziska, Schubert, Timm, Woerz, Franziska, Boldt, Karsten, Ueffing, Marius, Beyer, Tina

“…Intraflagellar transport (IFT) is a microtubule-based system that supports the assembly and maintenance of cilia. The dysfunction of IFT leads to ciliopathies…”
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Metabolomics in serum of patients with non-advanced age-related macular degeneration reveals aberrations in the glutamine pathway by Kersten, Eveline, Dammeier, Sascha, Ajana, Soufiane, Groenewoud, Joannes M M, Codrea, Marius, Klose, Franziska, Lechanteur, Yara T, Fauser, Sascha, Ueffing, Marius, Delcourt, Cécile, Hoyng, Carel B, de Jong, Eiko K, den Hollander, Anneke I

“…Age-related macular degeneration (AMD) is a common, progressive multifactorial vision-threatening disease and many genetic and environmental risk factors have…”
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Metabolomics in serum of patients with non-advanced age-related macular degeneration reveals aberrations in the glutamine pathway: PLoS One by Kersten, Eveline, Dammeier, Sascha, Ajana, Soufiane, Groenewoud, Joannes M M, Codrea, Marius, Klose, Franziska, Lechanteur, Yara T, Fauser, Sascha, Ueffing, Marius, Delcourt, Cécile, Hoyng, Carel B, de Jong, Eiko K, den Hollander, Anneke I

“…Age-related macular degeneration (AMD) is a common, progressive multifactorial vision-threatening disease and many genetic and environmental risk factors have…”
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Combined Targeted Analysis of Metabolites and Proteins in Tear Fluid With Regard to Clinical Applications by Dammeier, Sascha, Martus, Peter, Klose, Franziska, Seid, Michael, Bosch, Dario, D'Alvise, Janina, Ziemssen, Focke, Dimopoulos, Spyridon, Ueffing, Marius

“…To establish a robust workflow for combined mass spectrometry-based analysis of metabolites and proteins in tear fluid with regard to clinical applicability…”
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Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS G13D by Kennedy, Susan A, Jarboui, Mohamed-Ali, Srihari, Sriganesh, Raso, Cinzia, Bryan, Kenneth, Dernayka, Layal, Charitou, Theodosia, Bernal-Llinares, Manuel, Herrera-Montavez, Carlos, Krstic, Aleksandar, Matallanas, David, Kotlyar, Max, Jurisica, Igor, Curak, Jasna, Wong, Victoria, Stagljar, Igor, LeBihan, Thierry, Imrie, Lisa, Pillai, Priyanka, Lynn, Miriam A, Fasterius, Erik, Al-Khalili Szigyarto, Cristina, Breen, James, Kiel, Christina, Serrano, Luis, Rauch, Nora, Rukhlenko, Oleksii, Kholodenko, Boris N, Iglesias-Martinez, Luis F, Ryan, Colm J, Pilkington, Ruth, Cammareri, Patrizia, Sansom, Owen, Shave, Steven, Auer, Manfred, Horn, Nicola, Klose, Franziska, Ueffing, Marius, Boldt, Karsten, Lynn, David J, Kolch, Walter

“…Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their…”
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