Search Results - "Klose, Alanna"
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Arrayed Imaging Reflectometry monitoring of anti-viral antibody production throughout vaccination and breakthrough Covid-19
Published in PloS one (07-02-2023)“…Immune responses to COVID-19 infection and vaccination are individual and varied. There is a need to understand the timeline of vaccination efficacy against…”
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Label-Free, Multiplex Glycan Microarray Biosensor for Influenza Virus Detection
Published in Bioconjugate chemistry (17-03-2021)“…Newly emerging influenza viruses adapted from animal species pose significant pandemic threats to public health. An understanding of hemagglutinin (HA)…”
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A Stable Biotin-Streptavidin Surface Enables Multiplex, Label-Free Protein Detection by Aptamer and Aptamer-Protein Arrays Using Arrayed Imaging Reflectometry
Published in Sensors (Basel, Switzerland) (10-10-2020)“…While label-free multiplex sensor technology enables "mixing and matching" of different capture molecules in principle, in practice this has been rarely (if…”
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Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration
Published in eLife (06-06-2017)“…Neuromuscular junction degeneration is a prominent aspect of sarcopenia, the age-associated loss of skeletal muscle integrity. Previously, we showed that…”
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Prepubertal skeletal muscle growth requires Pax7-expressing satellite cell-derived myonuclear contribution
Published in Development (Cambridge) (15-10-2018)“…The functional role of Pax7-expressing satellite cells (SCs) in postnatal skeletal muscle development beyond weaning remains obscure. Therefore, the relevance…”
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Array-based analysis of SARS-CoV-2, other coronaviruses, and influenza antibodies in convalescent COVID-19 patients
Published in Biosensors & bioelectronics (01-12-2020)“…Detection of antibodies to upper respiratory pathogens is critical to surveillance, assessment of the immune status of individuals, vaccine development, and…”
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Inducible depletion of adult skeletal muscle stem cells impairs the regeneration of neuromuscular junctions
Published in eLife (27-08-2015)“…Skeletal muscle maintenance depends on motor innervation at neuromuscular junctions (NMJs). Multiple mechanisms contribute to NMJ repair and maintenance;…”
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StaphAIR: A Label-Free Antigen Microarray Approach to Detecting Anti-Staphylococcus aureus Antibody Responses in Orthopedic Infections
Published in Analytical chemistry (Washington) (12-10-2021)“…Arrayed imaging reflectometry (AIR) is an optical biosensor platform for simple, multiplex measurement of antigen-specific antibody responses in patient blood…”
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Smad4 restricts differentiation to promote expansion of satellite cell derived progenitors during skeletal muscle regeneration
Published in eLife (18-11-2016)“…Skeletal muscle regenerative potential declines with age, in part due to deficiencies in resident stem cells (satellite cells, SCs) and derived myogenic…”
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History of S. aureus Skin Infection Significantly Associates with History of Eczema Herpeticum in Patients with Atopic Dermatitis
Published in Dermatology and therapy (01-10-2023)“…Introduction Patients with atopic dermatitis (AD) are uniquely susceptible to a number of serious viral skin complications, including eczema herpeticum (EH),…”
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Selective Sexual Dimorphisms in Musculoskeletal and Cardiopulmonary Pathologic Manifestations and Mortality Incidence in the Tumor Necrosis Factor–Transgenic Mouse Model of Rheumatoid Arthritis
Published in Arthritis & rheumatology (Hoboken, N.J.) (01-09-2019)“…Objective To examine and quantify the sexual dimorphism in pathologic features manifested in the musculoskeletal and cardiopulmonary systems and incidence of…”
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Castration induces satellite cell activation that contributes to skeletal muscle maintenance
Published in JCSM rapid communications (01-01-2018)“…Aims Sarcopenia, the age‐related loss of skeletal muscle, is a side effect of androgen deprivation therapy (ADT) for prostate cancer patients. Resident stem…”
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