Search Results - "Kloos, Robin Q. H."

Allergic-like reactions to asparaginase: Atypical allergies without asparaginase inactivation by Kloos, Robin Q. H., Pieters, Rob, Escherich, Gabriele, van der Sluis, Inge M.

“…Background Asparaginase is an important component of pediatric acute lymphoblastic leukemia (ALL) therapy. Unfortunately, this treatment is hampered by…”
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A cost analysis of individualized asparaginase treatment in pediatric acute lymphoblastic leukemia by Kloos, Robin Q.H., Uyl‐de Groot, Carin A., Litsenburg, Raphaële R.L., Kaspers, Gertjan J.L., Pieters, Rob, der Sluis, Inge M.

“…Background Therapeutic drug monitoring (TDM) of asparaginase is necessary to respond to variability in asparaginase activity levels, detect silent…”
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Individualized Asparaginase Dosing in Childhood Acute Lymphoblastic Leukemia by Kloos, Robin Q H, Pieters, Rob, Jumelet, Florine M V, de Groot-Kruseman, Hester A, van den Bos, Cor, van der Sluis, Inge M

“…In the DCOG ALL-11 protocol, polyethylene glycol-conjugated asparaginase (PEGasparaginase) and asparaginase treatment of pediatric acute lymphoblastic leukemia…”
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Individualized dosing guidelines for PEGasparaginase and factors influencing the clearance: a population pharmacokinetic model by Kloos, Robin Q H, Mathôt, Ron, Pieters, Rob, van der Sluis, Inge M

“…Considerable inter- and intra-patient variability exist in serum activity levels of PEGasparaginase, essential for pediatric acute lymphoblastic leukemia…”
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Individualized dosing guidelines for PEGasparaginase and factors influencing the clearance: a population pharmacokinetic model by Kloos, Robin Q H, Mathôt, Ron, Pieters, Rob, Van der Sluis, Inge M

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The number of T cell allo-epitopes associates with CD4+ and CD8+ T-cell infiltration in pediatric cutaneous GVHD by Thus, Kirsten A., van Halteren, Astrid G.S., de Hond, Titus A.P., van Dijk, Marijke R., Kloos, Robin Q.H., Lankester, Arjan C., Bierings, Marc B., Spierings, Eric

“…•A sex-mismatched donor associated with CD4+ T cells in GVHD skin infiltrates.•Presence of PIRCHE-I associated with CD8+ T cells GVHD skin…”
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The effect of asparaginase therapy on methotrexate toxicity and efficacy in children with acute lymphoblastic leukemia by Kloos, Robin Q. H., Pieters, Rob, van den Bos, Cor, van Eijkelenburg, Natasha K. A., de Jonge, Robert, van der Sluis, Inge M.

“…Asparaginase and methotrexate (MTX), both essential for pediatric acute lymphoblastic leukemia therapy, are often used concomitantly. Depending on the…”
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A cost‐effectiveness analysis of Erwinia asparaginase therapy in children with acute lymphoblastic leukemia by Kloos, Robin Q. H., Litsenburg, Raphaële R. L., Wolf, Sarah, Wismans, Leonoor, Kaspers, Gertjan J. L., Uyl‐de Groot, Carin A., Pieters, Rob, der Sluis, Inge M.

“…Objectives Erwinia asparaginase is used as a second‐line formulation after a neutralizing hypersensitivity reaction to the first‐line formulation of…”
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Population pharmacokinetics of intravenous Erwinia asparaginase in pediatric acute lymphoblastic leukemia patients by Sassen, Sebastiaan D T, Mathôt, Ron A A, Pieters, Rob, Kloos, Robin Q H, de Haas, Valérie, Kaspers, Gertjan J L, van den Bos, Cor, Tissing, Wim J E, Te Loo, Maroeska, Bierings, Marc B, Kollen, Wouter J W, Zwaan, Christian M, van der Sluis, Inge M

“…Erwinia asparaginase is an important component in the treatment of pediatric acute lymphoblastic leukemia. A large variability in serum concentrations has been…”
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Hemorrhagic Cystitis in a Cohort of Pediatric Transplantations: Incidence, Treatment, Outcome, and Risk Factors by Kloos, Robin Q.H, Boelens, Jaap-Jan, de Jong, Tom P.V.M, Versluys, Birgitta, Bierings, Marc

“…Abstract Hemorrhagic cystitis (HC) can be a severe complication in hematopoietic stem cell transplantation (HSCT). To identify risk factors and etiology and to…”
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