Search Results - "Kloos, Arnold"

Measurable residual disease monitoring by NGS before allogeneic hematopoietic cell transplantation in AML by Thol, Felicitas, Gabdoulline, Razif, Liebich, Alessandro, Klement, Piroska, Schiller, Johannes, Kandziora, Christian, Hambach, Lothar, Stadler, Michael, Koenecke, Christian, Flintrop, Madita, Pankratz, Mira, Wichmann, Martin, Neziri, Blerina, Büttner, Konstantin, Heida, Bennet, Klesse, Sabrina, Chaturvedi, Anuhar, Kloos, Arnold, Göhring, Gudrun, Schlegelberger, Brigitte, Gaidzik, Verena I., Bullinger, Lars, Fiedler, Walter, Heim, Albert, Hamwi, Iyas, Eder, Matthias, Krauter, Jürgen, Schlenk, Richard F., Paschka, Peter, Döhner, Konstanze, Döhner, Hartmut, Ganser, Arnold, Heuser, Michael

“…Molecular measurable residual disease (MRD) assessment is not established in approximately 60% of acute myeloid leukemia (AML) patients because of the lack of…”
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Viral Infection of Tumors Overcomes Resistance to PD-1-immunotherapy by Broadening Neoantigenome-directed T-cell Responses by Woller, Norman, Gürlevik, Engin, Fleischmann-Mundt, Bettina, Schumacher, Anja, Knocke, Sarah, Kloos, Arnold M, Saborowski, Michael, Geffers, Robert, Manns, Michael P, Wirth, Thomas C, Kubicka, Stefan, Kühnel, Florian

“…There is evidence that viral oncolysis is synergistic with immune checkpoint inhibition in cancer therapy but the underlying mechanisms are unclear. Here, we…”
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Molecular retargeting of antibodies converts immune defense against oncolytic viruses into cancer immunotherapy by Niemann, Julia, Woller, Norman, Brooks, Jennifer, Fleischmann-Mundt, Bettina, Martin, Nikolas T., Kloos, Arnold, Knocke, Sarah, Ernst, Amanda M., Manns, Michael P., Kubicka, Stefan, Wirth, Thomas C., Gerardy-Schahn, Rita, Kühnel, Florian

“…Virus-neutralizing antibodies are a severe obstacle in oncolytic virotherapy. Here, we present a strategy to convert this unfavorable immune response into an…”
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Administration of Gemcitabine After Pancreatic Tumor Resection in Mice Induces an Antitumor Immune Response Mediated by Natural Killer Cells by Gürlevik, Engin, Fleischmann-Mundt, Bettina, Brooks, Jennifer, Demir, Ihsan Ekin, Steiger, Katja, Ribback, Silvia, Yevsa, Tetyana, Woller, Norman, Kloos, Arnold, Ostroumov, Dmitrij, Armbrecht, Nina, Manns, Michael P, Dombrowski, Frank, Saborowski, Michael, Kleine, Moritz, Wirth, Thomas C, Oettle, Helmut, Ceyhan, Güralp O, Esposito, Irene, Calvisi, Diego F, Kubicka, Stefan, Kühnel, Florian

“…Background & Aims Even after potentially curative R0 resection, patients with pancreatic ductal adenocarcinoma (PDAC) have a poor prognosis owing to high rates…”
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Fludarabine, cytarabine, and idarubicin with or without venetoclax in patients with relapsed/refractory acute myeloid leukemia by Shahswar, Rabia, Beutel, Gernot, Gabdoulline, Razif, Schwarzer, Adrian, Kloos, Arnold, Koenecke, Christian, Stadler, Michael, Gohring, Gudrun, Behrens, Yvonne Lisa, Li, Zhixiong, Dallmann, Louisa-Kristin, Klement, Piroska, Albert, Catherin, Wichmann, Martin, Alwie, Yasmine, Benner, Axel, Saadati, Maral, Ganser, Arnold, Thol, Felicitas, Heuser, Michael

“…Treatment options for relapsed and refractory acute myeloid leukemia patients (R/R AML) are limited. This retrospective cohort study compares safety and…”
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Improved Activity against Acute Myeloid Leukemia with Chimeric Antigen Receptor (CAR)-NK-92 Cells Designed to Target CD123 by Morgan, Michael A., Kloos, Arnold, Lenz, Daniela, Kattre, Nadine, Nowak, Juliette, Bentele, Marco, Keisker, Maximilian, Dahlke, Julia, Zimmermann, Katharina, Sauer, Martin, Heuser, Michael, Schambach, Axel

“…Anti-cancer activity can be improved by engineering immune cells to express chimeric antigen receptors (CARs) that recognize tumor-associated antigens…”
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Scalable generation of functional human iPSC-derived CAR-macrophages that efficiently eradicate CD19-positive leukemia by Abdin, Shifaa M., Paasch, Daniela, Kloos, Arnold, Oliveira, Marco Carvalho, Jang, Mi-Sun, Ackermann, Mania, Stamopoulou, Andriana, Mroch, Philipp J, Falk, Christine S, von Kaisenberg, Constantin S, Schambach, Axel, Heuser, Michael, Moritz, Thomas, Hansen, Gesine, Morgan, Michael, Lachmann, Nico

“…BackgroundMacrophages have recently become attractive therapeutics in cancer immunotherapy. The potential of macrophages to infiltrate and influence solid…”
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Clinical Implications and Dynamics of Clonal Hematopoiesis in Anti‐CD19 CAR T‐cell Treated Patients by Panagiota, Victoria, Kerschbaum, Johanna Franziska, Penack, Olaf, Stein, Catarina M., Arends, Christopher M., Koenecke, Christian, Strzelecka, Paulina M., Kloos, Arnold, Wiegand, Laura, Lasch, Alina, Altwasser, Robert, Halik, Adriane, Gabdoulline, Razif, Thomson, Julia, Weibl, Konstantin, Franke, Georg‐Nikolaus, Berger, Carolina, Hasenkamp, Justin, Ayuk, Francis, Na, Il‐Kang, Beutel, Gernot, Keller, Ulrich, Bullinger, Lars, Wulf, Gerald Georg, Kröger, Nicolaus, Vucinic, Vladan, Heuser, Michael, Damm, Frederik

“…Recent evidence revealed important interactions between clonal hematopoiesis (CH) and cellular therapies established for the treatment of hematologic…”
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P1278: MEASURABLE RESIDUAL DISEASE ASSESSMENT IN THE PROSPECTIVE HAPLOMUD STUDY by Arnhardt, Isabell, Kloos, Arnold, Kattre, Nadine, Gabdoulline, Razif, Lasch, Alina, Alwie, Yasmine, Kröger, Nicolaus, Trenschel, Rudolf, Stelljes, Matthias, Eder, Matthias, Bethge, Wolfgang, Bug, Gesine, Solano Vercet, Carlos, Sanz, Jaime, Sanchez‐Guijo, Fermin, Rambaldi, Alessandro, Bonifazi, Francesca, Patriarca, Francesca, Šťastná Marková, Marketa, Wohlfarth, Philipp, Greinix, Hildegard, Schwarzer, Adrian, Heuser, Michael

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Allogeneic, CD34 +, Umbilical Cordblood-Derived NK Cell Adoptive Immunotherapy for the Treatment of Acute Myeloid Leukemia Patients with Measurable Residual Disease by Heuser, Michael, Tschan-Plessl, Astrid, Thol, Felicitas, Schwarzer, Adrian, Kloos, Arnold, Kattre, Nadine, Passweg, Jakob, Pinkernell, Kai, Ganser, Arnold

“…Although the majority of patients with acute myeloid leukemia (AML) achieve complete remission (CR), most of them relapse due to measurable residual disease…”
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DEK-NUP214 Acute Myeloid Leukemia Depends on CRM1 In Vivo by Charles Cano, Fiorella, Kloos, Arnold, Hebalkar, Rucha Yeshwanta, Gabdoulline, Razif, Fangmann, Thomas, Landesman, Yosef, Döhner, Konstanze, Shcherbata, Halyna R., Ganser, Arnold, Heuser, Michael

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Preclinical Assessment of Suitable Natural Killer Cell Sources for Chimeric Antigen Receptor Natural Killer-Based "Off-the-Shelf" Acute Myeloid Leukemia Immunotherapies by Kloess, Stephan, Oberschmidt, Olaf, Dahlke, Julia, Vu, Xuan-Khang, Neudoerfl, Christine, Kloos, Arnold, Gardlowski, Tanja, Matthies, Nadine, Heuser, Michael, Meyer, Johann, Sauer, Martin, Falk, Christine, Koehl, Ulrike, Schambach, Axel, Morgan, Michael A

“…The introduction of chimeric antigen receptors (CARs) to augment the anticancer activity of immune cells represents one of the major clinical advances in…”
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A 19‐color single‐tube full spectrum flow cytometry assay for the detection of measurable residual disease in acute myeloid leukemia by Fokken, Hendrik, Waclawski, Julian, Kattre, Nadine, Kloos, Arnold, Müller, Sebastian, Ettinger, Max, Kacprowski, Tim, Heuser, Michael, Maetzig, Tobias, Schwarzer, Adrian

“…Multiparameter flow cytometry (MFC) has emerged as a standard method for quantifying measurable residual disease (MRD) in acute myeloid leukemia. However, the…”
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Single and Combinational Multiplex Base-Edited 'Universal' CAR T Cells in a Humanised Model of Primary CD7+CD33+ AML by Kloos, Arnold, Georgiadis, Christos, Etuk, Annie, Gkazi, Soragia Athina, Syed, Farhatullah, Braybrook, Toni, Zhan, Hong, Kadirkamanathan, Renuka, Kattre, Nadine, Görlich, Kerstin, Fangmann, Thomas, Schambach, Axel, Sauer, Martin G., Heuser, Michael, Qasim, Waseem

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Optimized induction of mitochondrial apoptosis for chemotherapy-free treatment of BCR-ABL+acute lymphoblastic leukemia by Scherr, Michaela, Kirchhoff, Hanna, Battmer, Karin, Wohlan, Katharina, Lee, Chun-Wei, Ricke-Hoch, Melanie, Erschow, Sergej, Law, Edward, Kloos, Arnold, Heuser, Michael, Ganser, Arnold, Hilfiker-Kleiner, Denise, Heidenreich, Olaf, Eder, Matthias

“…BCR-ABL+acute lymphoblastic leukemia (ALL) in adults has a poor prognosis with allogeneic stem cell transplantation (SCT) considered the best curative option…”
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An optimized lentiviral vector system for conditional RNAi and efficient cloning of microRNA embedded short hairpin RNA libraries by Adams, Felix F, Heckl, Dirk, Hoffmann, Thomas, Talbot, Steven R, Kloos, Arnold, Thol, Felicitas, Heuser, Michael, Zuber, Johannes, Schambach, Axel, Schwarzer, Adrian

“…Abstract RNA interference (RNAi) and CRISPR-Cas9-based screening systems have emerged as powerful and complementary tools to unravel genetic dependencies…”
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Functional Screening for Pathways Regulating Chemoresistance and Sensitivity in Leukemia Stem Cells by Mintzas, Konstantinos, Kloos, Arnold, Gabdoulline, Razif, Schottmann, Renate, Danisch, Simon, Stripecke, Renata, Ganser, Arnold, Thol, Felicitas, Heuser, Michael

“…INTRODUCTION On average 5 recurrent mutations are present in each patient with acute myeloid leukemia (AML). Many mutated genes are implicated as tumor…”
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Fla-IDA Chemotherapy with or without Venetoclax in Patients with Relapsed/Refractory Acute Myeloid Leukemia by Shahswar, Rabia, Beutel, Gernot, Gabdoulline, Razif, Schwarzer, Adrian, Kloos, Arnold, Koenecke, Christian, Stadler, Michael, Göhring, Gudrun, Schlegelberger, Brigitte, Li, Zhixiong, Dallmann, Louisa-Kristin, Wienecke, Clara, Klement, Piroska, Albert, Catherin, Wichmann, Martin, Alwie, Yasmine, Benner, Axel, Saadati, Maral, Ganser, Arnold, Thol, Felicitas R., Heuser, Michael

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Targeted Inhibition of the NUP98-NSD1 Fusion Oncogene in AML by Mohanty, Sagarajit, Jyotsana, Nidhi, Sharma, Amit, Othman, Basem, Kloos, Arnold, Mandhania, Madhvi, Schottmann, Renate, Ramsay, Euan, Vornlocher, Hans- Peter, Ganser, Arnold, Thol, Felicitas, Heuser, Michael

“…Background: NUP98-NSD1 positive AML is a poor prognostic subgroup within pediatric and adult AML (Thol et al., 2013). However, targeted therapeutics for these…”
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Posttransplantation MRD monitoring in patients with AML by next-generation sequencing using DTA and non-DTA mutations by Heuser, Michael, Heida, Bennet, Büttner, Konstantin, Wienecke, Clara Philine, Teich, Katrin, Funke, Carolin, Brandes, Maximilian, Klement, Piroska, Liebich, Alessandro, Wichmann, Martin, Neziri, Blerina, Chaturvedi, Anuhar, Kloos, Arnold, Mintzas, Konstantinos, Gaidzik, Verena I., Paschka, Peter, Bullinger, Lars, Fiedler, Walter, Heim, Albert, Puppe, Wolfram, Krauter, Jürgen, Döhner, Konstanze, Döhner, Hartmut, Ganser, Arnold, Stadler, Michael, Hambach, Lothar, Gabdoulline, Razif, Thol, Felicitas

“…Next-generation sequencing (NGS)-based measurable residual disease (MRD) monitoring in patients with acute myeloid leukemia (AML) is widely applicable and…”
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