Search Results - "Kloor, Matthias"

Colorectal cancer by Brenner, Hermann, Prof, Kloor, Matthias, MD, Pox, Christian Peter, MD

“…Summary More than 1·2 million patients are diagnosed with colorectal cancer every year, and more than 600 000 die from the disease. Incidence strongly varies…”
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Smoking, alcohol consumption and colorectal cancer risk by molecular pathological subtypes and pathways by Amitay, Efrat L., Carr, Prudence R., Jansen, Lina, Roth, Wilfried, Alwers, Elizabeth, Herpel, Esther, Kloor, Matthias, Bläker, Hendrik, Chang-Claude, Jenny, Brenner, Hermann, Hoffmeister, Michael

“…Background Smoking and alcohol increase risk for colorectal malignancies. However, colorectal cancer (CRC) is a heterogenic disease and associations with the…”
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The Immune Biology of Microsatellite-Unstable Cancer by Kloor, Matthias, von Knebel Doeberitz, Magnus

“…Deficient DNA mismatch repair (MMR) boosts the accumulation of frameshift mutations in genes encompassing coding microsatellites (cMS). This results in the…”
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A Frameshift Peptide Neoantigen-Based Vaccine for Mismatch Repair-Deficient Cancers: A Phase I/IIa Clinical Trial by Kloor, Matthias, Reuschenbach, Miriam, Pauligk, Claudia, Karbach, Julia, Rafiyan, Mohammad-Reza, Al-Batran, Salah-Eddin, Tariverdian, Mirjam, Jäger, Elke, von Knebel Doeberitz, Magnus

“…DNA mismatch repair (MMR) deficiency is a hallmark of Lynch syndrome, the most common inherited cancer syndrome. MMR-deficient cancer cells accumulate numerous…”
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Three molecular pathways model colorectal carcinogenesis in Lynch syndrome by Ahadova, Aysel, Gallon, Richard, Gebert, Johannes, Ballhausen, Alexej, Endris, Volker, Kirchner, Martina, Stenzinger, Albrecht, Burn, John, von Knebel Doeberitz, Magnus, Bläker, Hendrik, Kloor, Matthias

“…Lynch syndrome is caused by germline mutations of DNA mismatch repair (MMR) genes. MMR deficiency has long been regarded as a secondary event in the…”
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HLA class II antigen-processing pathway in tumors: Molecular defects and clinical relevance by Seliger, Barbara, Kloor, Matthias, Ferrone, Soldano

“…The human leukocyte antigen (HLA) class II antigen-processing machinery (APM) presents to cognate CD4 + T-cells antigenic peptides mainly generated from…”
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Complex pattern of immune evasion in MSI colorectal cancer by Ozcan, Mine, Janikovits, Jonas, von Knebel Doeberitz, Magnus, Kloor, Matthias

“…Mismatch repair (MMR)-deficient cancers accumulate multiple insertion/deletion mutations at coding microsatellites (cMS), which give rise to frameshift peptide…”
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Prevalence of mismatch repair-deficient crypt foci in Lynch syndrome: a pathological study by Kloor, Matthias, Dr, Huth, Cathrin, Voigt, Anita Y, MSc, Benner, Axel, MSc, Schirmacher, Peter, Prof, von Knebel Doeberitz, Magnus, Prof, Bläker, Hendrik, Prof

“…Summary Background Lynch syndrome is an inherited tumour predisposition syndrome caused by germline mutations of DNA mismatch repair ( MMR ) genes. Mutation…”
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Associations Between Molecular Classifications of Colorectal Cancer and Patient Survival: A Systematic Review by Alwers, Elizabeth, Jia, Min, Kloor, Matthias, Bläker, Hendrik, Brenner, Hermann, Hoffmeister, Michael

“…Colorectal cancer (CRC) is a heterogeneous disease with different mechanisms of pathogenesis. Classification systems have been proposed based on molecular…”
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Mismatch repair deficiency is a rare but putative therapeutically relevant finding in non-liver fluke associated cholangiocarcinoma by Goeppert, Benjamin, Roessler, Stephanie, Renner, Marcus, Singer, Stephan, Mehrabi, Arianeb, Vogel, Monika Nadja, Pathil, Anita, Czink, Elena, Köhler, Bruno, Springfeld, Christoph, Pfeiffenberger, Jan, Rupp, Christian, Weiss, Karl Heinz, Schirmacher, Peter, von Knebel Doeberitz, Magnus, Kloor, Matthias

“…Background A major molecular pathway of genetic instability in cancer is DNA mismatch repair deficiency. High-level microsatellite instability (MSI-H) is…”
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The Association Between Mutations in BRAF and Colorectal Cancer–Specific Survival Depends on Microsatellite Status and Tumor Stage by Bläker, Hendrik, Alwers, Elizabeth, Arnold, Alexander, Herpel, Esther, Tagscherer, Katrin E., Roth, Wilfried, Jansen, Lina, Walter, Viola, Kloor, Matthias, Chang-Claude, Jenny, Brenner, Hermann, Hoffmeister, Michael

“…Colorectal tumors with mutations in BRAF and microsatellite stability (MSS) have been associated with adverse outcomes of patients. Combined tests for…”
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Immune evasion of microsatellite unstable colorectal cancers by Kloor, Matthias, Michel, Sara, von Knebel Doeberitz, Magnus

“…Colorectal cancers (CRC) develop through 2 major pathways of genetic instability. In contrast to the majority of CRCs, which are characterized by chromosomal…”
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Colonoscopy and Reduction of Colorectal Cancer Risk by Molecular Tumor Subtypes: A Population-Based Case-Control Study by Hoffmeister, Michael, Bläker, Hendrik, Jansen, Lina, Alwers, Elizabeth, Amitay, Efrat L., Carr, Prudence R., Kloor, Matthias, Herpel, Esther, Roth, Wilfried, Chang-Claude, Jenny, Brenner, Hermann

“…In previous studies, the protective effect of colonoscopy was generally stronger for distal colorectal cancer than for proximal colorectal cancer (CRC). This…”
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Immune Escape and Survival Mechanisms in Circulating Tumor Cells of Colorectal Cancer by STEINERT, Gunnar, SCHÖLCH, Sebastian, RAHBARI, Nuh N, BÜCHLER, Markus W, STOECKLEIN, Nikolas H, WEITZ, Jürgen, KOCH, Moritz, NIEMIETZ, Thomas, IWATA, Naoki, GARCIA, Sebastián A, BEHRENS, Bianca, VOIGT, Anita, KLOOR, Matthias, BENNER, Axel, BORK, Ulrich

“…The prognosis of colorectal cancer is closely linked to the occurrence of distant metastases. Systemic dissemination is most likely caused by circulating tumor…”
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Localization and Density of Immune Cells in the Invasive Margin of Human Colorectal Cancer Liver Metastases Are Prognostic for Response to Chemotherapy by HALAMA, Niels, MICHEL, Sara, FEYEN, Nadine, MARTENS, Uwe M, BECKHOVE, Philipp, GNJATIC, Sacha, SCHIRMACHER, Peter, HERPEL, Esther, WEITZ, Juergen, GRABE, Niels, JAEGER, Dirk, KLOOR, Matthias, ZOERNIG, Inka, BENNER, Axel, SPILLE, Anna, POMMERENCKE, Thora, VON KNEBEL DOEBERITZ, Magnus, FOLPRECHT, Gunnar, LUBER, Birgit

“…Analysis of tumor-infiltrating lymphocytes (TIL) in primary human colorectal cancer (CRC) by in situ immunohistochemical staining supports the hypothesis that…”
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Does Side Really Matter? Survival Analysis among Patients with Right- Versus Left-Sided Colon Cancer: A Propensity Score-Adjusted Analysis by Klose, Johannes, Kloor, Matthias, Warschkow, René, Antony, Pia, Liesenfeld, Lukas F., Büchler, Markus W., Schneider, Martin, Tarantino, Ignazio

“…Background Right- and left-sided colon cancer are increasingly regarded as two independent disease entities based on different gene expression profiles as well…”
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Prognostic significance of microsatellite‐instability in gastric and gastroesophageal junction cancer patients undergoing neoadjuvant chemotherapy by Haag, Georg Martin, Czink, Elena, Ahadova, Aysel, Schmidt, Thomas, Sisic, Leila, Blank, Susanne, Heger, Ulrike, Apostolidis, Leonidas, Berger, Anne Katrin, Springfeld, Christoph, Lasitschka, Felix, Jäger, Dirk, Knebel Doeberitz, Magnus, Kloor, Matthias

“…Perioperative systemic treatment is standard of care for Caucasian patients with locally advanced, resectable gastric adenocarcinoma. The prognostic relevance…”
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Mathematical modeling of multiple pathways in colorectal carcinogenesis using dynamical systems with Kronecker structure by Haupt, Saskia, Zeilmann, Alexander, Ahadova, Aysel, Bläker, Hendrik, von Knebel Doeberitz, Magnus, Kloor, Matthias, Heuveline, Vincent

“…Like many other types of cancer, colorectal cancer (CRC) develops through multiple pathways of carcinogenesis. This is also true for colorectal carcinogenesis…”
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BRAF V600E‐specific immunohistochemistry for the exclusion of Lynch syndrome in MSI‐H colorectal cancer by Capper, David, Voigt, Anita, Bozukova, Gergana, Ahadova, Aysel, Kickingereder, Philipp, von Deimling, Andreas, von Knebel Doeberitz, Magnus, Kloor, Matthias

“…The differentiation between hereditary and sporadic microsatellite‐unstable (MSI‐H) colorectal cancer is a crucial step in Lynch syndrome diagnostics. Within…”
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Natural Killer Cells are Scarce in Colorectal Carcinoma Tissue Despite High Levels of Chemokines and Cytokines by HALAMA, Niels, BRAUN, Monika, SCHIRMACHER, Peter, BRAND, Karsten, GRABE, Niels, FALK, Christine S, KAHLERT, Christoph, SPILLE, Anna, QUACK, Christian, RAHBARI, Nuh, KOCH, Moritz, WEITZ, Jürgen, KLOOR, Matthias, ZOERNIG, Inka

“…Tumor infiltrating T lymphocytes in colorectal cancer (CRC) have prognostic impact, but the role of natural killer (NK) cells in CRC tissue is unclear. The…”
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