Search Results - "Klontz, Erik"

Chop-Chop: The Future of Bacterial Enzymes in Transfusion Medicine by Klontz, Erik H.

“…•Bacterial enzymes rapidly degrade antibodies for treatment of autoimmune disease.•Imlifidase (IdeS) is a first-in-class medication advancing through clinical…”
Get full text

Laboratory Testing for Powassan Virus: Past, Present, and Future by Klontz, Erik H, Chowdhury, Navid, Branda, John A

“…Abstract Powassan virus is a tick-borne flavivirus that can cause severe neuroinvasive disease, with areas of endemicity in the Northeast and Midwest United…”
Get full text

Insights into substrate recognition and specificity for IgG by Endoglycosidase S2 by Aytenfisu, Asaminew H, Deredge, Daniel, Klontz, Erik H, Du, Jonathan, Sundberg, Eric J, MacKerell, Alexander D

“…Antibodies bind foreign antigens with high affinity and specificity leading to their neutralization and/or clearance by the immune system. The conserved…”
Get full text

Case 4-2024: A 39-Year-Old Man with Fever and Headache after International Travel by Ryan, Edward T., Succi, Marc D., Paras, Molly L., Klontz, Erik H.

“…A 39-year-old man was evaluated at the hospital during the summer because of 4 days of fever with shaking chills, headache, and fatigue after returning from…”
Get full text

Structure and dynamics of an α-fucosidase reveal a mechanism for highly efficient IgG transfucosylation by Klontz, Erik H., Li, Chao, Kihn, Kyle, Fields, James K., Beckett, Dorothy, Snyder, Greg A., Wintrode, Patrick L., Deredge, Daniel, Wang, Lai-Xi, Sundberg, Eric J.

“…Fucosylation is important for the function of many proteins with biotechnical and medical applications. Alpha-fucosidases comprise a large enzyme family that…”
Get full text

Structural basis of mammalian high-mannose N-glycan processing by human gut Bacteroides by Trastoy, Beatriz, Du, Jonathan J., Klontz, Erik H., Li, Chao, Cifuente, Javier O., Wang, Lai-Xi, Sundberg, Eric J., Guerin, Marcelo E.

“…The human gut microbiota plays a central role not only in regulating the metabolism of nutrients but also promoting immune homeostasis, immune responses and…”
Get full text

Comparative Evaluation of Commercial Test Kits Cleared for Use in Modified Two-Tiered Testing Algorithms for Serodiagnosis of Lyme Disease by Lewandrowski, Elizabeth L, Turbett, Sarah E, Nigrovic, Lise E, Klontz, Erik H, Branda, John A

“…Abstract Background Modified 2-tiered testing (MTTT) for Lyme disease utilizes automatable, high throughput immunoassays (AHTIs) in both tiers without…”
Get full text

Structural insights into the mechanisms and specificities of IgG-active endoglycosidases by Du, Jonathan J, Klontz, Erik H, Guerin, Marcelo E, Trastoy, Beatriz, Sundberg, Eric J

“…Abstract The conserved N-glycan on Asn297 of immunoglobulin G (IgG) has significant impacts on antibody effector functions, and is a frequent target for…”
Get full text

Sculpting therapeutic monoclonal antibody N-glycans using endoglycosidases by Trastoy, Beatriz, Du, Jonathan J., García-Alija, Mikel, Li, Chao, Klontz, Erik H., Wang, Lai-Xi, Sundberg, Eric J., Guerin, Marcelo E.

“…Immunoglobulin G (IgG) monoclonal antibodies are a prominent and expanding class of therapeutics used for the treatment of diverse human disorders. The…”
Get full text

Cerebrospinal fluid metagenomics has greatest added value as a test for Powassan virus among patients in New England with suspected central nervous system infection by Klontz, Erik H., Solomon, Isaac H., Turbett, Sarah E., Lemieux, Jacob E., Branda, John A.

“…Cerebrospinal fluid (CSF) metagenomic next generation sequencing (mNGS) can detect diverse pathogens in patients with central nervous system infection. Due to…”
Get full text

Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases by Trastoy, Beatriz, Du, Jonathan J., Cifuente, Javier O., Rudolph, Lorena, García-Alija, Mikel, Klontz, Erik H., Deredge, Daniel, Sultana, Nazneen, Huynh, Chau G., Flowers, Maria W., Li, Chao, Sastre, Diego E., Wang, Lai-Xi, Corzana, Francisco, Mallagaray, Alvaro, Sundberg, Eric J., Guerin, Marcelo E.

“…Bacterial pathogens have evolved intricate mechanisms to evade the human immune system, including the production of immunomodulatory enzymes. Streptococcus…”
Get full text

Structural basis for the recognition of complex-type N-glycans by Endoglycosidase S by Trastoy, Beatriz, Klontz, Erik, Orwenyo, Jared, Marina, Alberto, Wang, Lai-Xi, Sundberg, Eric J., Guerin, Marcelo E.

“…Endoglycosidase S (EndoS) is a bacterial endo-β-N-acetylglucosaminidase that specifically catalyzes the hydrolysis of the β-1,4 linkage between the first two…”
Get full text

Molecular Basis of Selective Cytokine Signaling Inhibition by Antibodies Targeting a Shared Receptor by Fields, James K, Kihn, Kyle, Birkedal, Gabriel S, Klontz, Erik H, Sjöström, Kjell, Günther, Sebastian, Beadenkopf, Robert, Forsberg, Göran, Liberg, David, Snyder, Greg A, Deredge, Daniel, Sundberg, Eric J

“…Interleukin-1 (IL-1) family cytokines are potent mediators of inflammation, acting to coordinate local and systemic immune responses to a wide range of…”
Get full text

Mass Spectrometry-Based Methods to Determine the Substrate Specificities and Kinetics of N-Linked Glycan Hydrolysis by Endo-β-N-Acetylglucosaminidases by Du, Jonathan J, Sastre, Diego, Trastoy, Beatriz, Roberts, Blaine, Deredge, Daniel, Klontz, Erik H, Flowers, Maria W, Sultana, Nazneen, Guerin, Marcelo E, Sundberg, Eric J

“…Glycosylation is a common posttranslational modification of proteins and refers to the covalent addition of glycans, chains of polysaccharides, onto proteins…”
Get more information

GH18 endo-β-N-acetylglucosaminidases use distinct mechanisms to process hybrid-type N-linked glycans by Trastoy, Beatriz, Du, Jonathan J., Li, Chao, García-Alija, Mikel, Klontz, Erik H., Roberts, Blaine R., Donahue, Thomas C., Wang, Lai-Xi, Sundberg, Eric J., Guerin, Marcelo E.

“…N-glycosylation is one of the most abundant posttranslational modifications of proteins, essential for many physiological processes, including protein folding,…”
Get full text

Getting oriented with antibodies by Klontz, Erik H, Sundberg, Eric J

“…Neisseria meningitidis is a Gram-negative bacterium capable of causing deadly invasive disease. Two recently developed vaccines against N. meningitidis…”
Get more information

Structure and Dynamics of FosA-Mediated Fosfomycin Resistance in Klebsiella pneumoniae and Escherichia coli by Klontz, Erik H, Tomich, Adam D, Günther, Sebastian, Lemkul, Justin A, Deredge, Daniel, Silverstein, Zach, Shaw, JoAnna F, McElheny, Christi, Doi, Yohei, Wintrode, Patrick L, MacKerell, Jr, Alexander D, Sluis-Cremer, Nicolas, Sundberg, Eric J

“…Fosfomycin exhibits broad-spectrum antibacterial activity and is being reevaluated for the treatment of extensively drug-resistant pathogens. Its activity in…”
Get full text

Small-Molecule Inhibitor of FosA Expands Fosfomycin Activity to Multidrug-Resistant Gram-Negative Pathogens by Tomich, Adam D, Klontz, Erik H, Deredge, Daniel, Barnard, John P, McElheny, Christi L, Eshbach, Megan L, Weisz, Ora A, Wintrode, Patrick, Doi, Yohei, Sundberg, Eric J, Sluis-Cremer, Nicolas

“…The spread of multidrug or extensively drug-resistant Gram-negative bacteria is a serious public health issue. There are too few new antibiotics in development…”
Get full text

Babesia microti Variant With Multiple Resistance Mutations Detected in an Immunocompromised Patient Receiving Atovaquone Prophylaxis by Holbrook, Nolan R, Klontz, Erik H, Adams, Gordon C, Schnittman, Samuel R, Issa, Nicolas C, Bond, Sheila A, Branda, John A, Lemieux, Jacob E

“…Abstract We report Babesia microti genomic sequences with multiple mutations in the atovaquone-target region of cytochrome b, including a newly identified…”
Get full text

Molecular Basis of Broad Spectrum N‑Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2 by Klontz, Erik H, Trastoy, Beatriz, Deredge, Daniel, Fields, James K, Li, Chao, Orwenyo, Jared, Marina, Alberto, Beadenkopf, Robert, Günther, Sebastian, Flores, Jair, Wintrode, Patrick L, Wang, Lai-Xi, Guerin, Marcelo E, Sundberg, Eric J

“…Immunoglobulin G (IgG) glycosylation critically modulates antibody effector functions. Streptococcus pyogenes secretes a unique endo-β-N-acetylglucosaminidase,…”
Get full text