Search Results - "Klomp, Jennifer E"

Comprehensive transcriptomic profiling reveals SOX7 as an early regulator of angiogenesis in hypoxic human endothelial cells by Klomp, Jeff, Hyun, James, Klomp, Jennifer E., Pajcini, Kostandin, Rehman, Jalees, Malik, Asrar B.

“…Endothelial cells (ECs) lining the vasculature of vertebrates respond to low oxygen (hypoxia) by maintaining vascular homeostasis and initiating adaptive…”
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Transcriptional Coactivators Are Not Required for Herpes Simplex Virus Type 1 Immediate-Early Gene Expression In Vitro by KUTLUAY, Sebla B, DEVOS, Sarah L, KLOMP, Jennifer E, TRIEZENBERG, Steven J

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The ERK mitogen-activated protein kinase signaling network: the final frontier in RAS signal transduction by Klomp, Jennifer E, Klomp, Jeff A, Der, Channing J

“…The RAF-MEK-ERK mitogen-activated protein kinase (MAPK) cascade is aberrantly activated in a diverse set of human cancers and the RASopathy group of genetic…”
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Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer by Bryant, Kirsten L., Stalnecker, Clint A., Zeitouni, Daniel, Klomp, Jennifer E., Peng, Sen, Tikunov, Andrey P., Gunda, Venugopal, Pierobon, Mariaelena, Waters, Andrew M., George, Samuel D., Tomar, Garima, Papke, Björn, Hobbs, G. Aaron, Yan, Liang, Hayes, Tikvah K., Diehl, J. Nathaniel, Goode, Gennifer D., Chaika, Nina V., Wang, Yingxue, Zhang, Guo-Fang, Witkiewicz, Agnieszka K., Knudsen, Erik S., Petricoin, Emanuel F., Singh, Pankaj K., Macdonald, Jeffrey M., Tran, Nhan L., Lyssiotis, Costas A., Ying, Haoqiang, Kimmelman, Alec C., Cox, Adrienne D., Der, Channing J.

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by KRAS- and autophagy-dependent tumorigenic growth, but the role of KRAS in supporting autophagy has…”
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Combination Therapies with CDK4/6 Inhibitors to Treat KRAS-Mutant Pancreatic Cancer by Goodwin, Craig M, Waters, Andrew M, Klomp, Jennifer E, Javaid, Sehrish, Bryant, Kirsten L, Stalnecker, Clint A, Drizyte-Miller, Kristina, Papke, Bjoern, Yang, Runying, Amparo, Amber M, Ozkan-Dagliyan, Irem, Baldelli, Elisa, Calvert, Valerie, Pierobon, Mariaelena, Sorrentino, Jessica A, Beelen, Andrew P, Bublitz, Natalie, Lüthen, Mareen, Wood, Kris C, Petricoin, Emanuel F, Sers, Christine, McRee, Autumn J, Cox, Adrienne D, Der, Channing J

“…Mutational loss of CDKN2A (encoding p16INK4A) tumor-suppressor function is a key genetic step that complements activation of KRAS in promoting the development…”
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TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors by Edwards, A Cole, Stalnecker, Clint A, Jean Morales, Alexis, Taylor, Khalilah E, Klomp, Jennifer E, Klomp, Jeffrey A, Waters, Andrew M, Sudhakar, Niranjan, Hallin, Jill, Tang, Tracy T, Olson, Peter, Post, Leonard, Christensen, James G, Cox, Adrienne D, Der, Channing J

“…Primary/intrinsic and treatment-induced acquired resistance limit the initial response rate to and long-term efficacy of direct inhibitors of the KRASG12C…”
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Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy by Holderfield, Matthew, Lee, Bianca J., Jiang, Jingjing, Tomlinson, Aidan, Seamon, Kyle J., Mira, Alessia, Patrucco, Enrico, Goodhart, Grace, Dilly, Julien, Gindin, Yevgeniy, Dinglasan, Nuntana, Wang, Yingyun, Lai, Lick Pui, Cai, Shurui, Jiang, Lingyan, Nasholm, Nicole, Shifrin, Nataliya, Blaj, Cristina, Shah, Harshit, Evans, James W., Montazer, Nilufar, Lai, Oliver, Shi, Jade, Ahler, Ethan, Quintana, Elsa, Chang, Stephanie, Salvador, Anthony, Marquez, Abby, Cregg, Jim, Liu, Yang, Milin, Anthony, Chen, Anqi, Ziv, Tamar Bar, Parsons, Dylan, Knox, John E., Klomp, Jennifer E., Roth, Jennifer, Rees, Matthew, Ronan, Melissa, Cuevas-Navarro, Antonio, Hu, Feng, Lito, Piro, Santamaria, David, Aguirre, Andrew J., Waters, Andrew M., Der, Channing J., Ambrogio, Chiara, Wang, Zhengping, Gill, Adrian L., Koltun, Elena S., Smith, Jacqueline A. M., Wildes, David, Singh, Mallika

“…RAS oncogenes (collectively NRAS , HRAS and especially KRAS ) are among the most frequently mutated genes in cancer, with common driver mutations occurring at…”
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Septin2 mediates podosome maturation and endothelial cell invasion associated with angiogenesis by Collins, Kerrie B, Kang, Hojin, Matsche, Jacob, Klomp, Jennifer E, Rehman, Jalees, Malik, Asrar B, Karginov, Andrei V

“…Podosomes are compartmentalized actin-rich adhesions, defined by their ability to locally secrete proteases and remodel extracellular matrix. Matrix remodeling…”
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The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancer by Diehl, J. Nathaniel, Klomp, Jennifer E., Snare, Kayla R., Hibshman, Priya S., Blake, Devon R., Kaiser, Zane D., Gilbert, Thomas S.K., Baldelli, Elisa, Pierobon, Mariaelena, Papke, Björn, Yang, Runying, Hodge, Richard G., Rashid, Naim U., Petricoin, Emanuel F., Herring, Laura E., Graves, Lee M., Cox, Adrienne D., Der, Channing J.

“…Oncogenic KRAS drives cancer growth by activating diverse signaling networks, not all of which have been fully delineated. We set out to establish a…”
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Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer by Klomp, Jennifer E, Diehl, J Nathaniel, Klomp, Jeffrey A, Edwards, A Cole, Yang, Runying, Morales, Alexis J, Taylor, Khalilah E, Drizyte-Miller, Kristina, Bryant, Kirsten L, Schaefer, Antje, Johnson, Jared L, Huntsman, Emily M, Yaron, Tomer M, Pierobon, Mariaelena, Baldelli, Elisa, Prevatte, Alex W, Barker, Natalie K, Herring, Laura E, Petricoin, 3rd, Emanuel F, Graves, Lee M, Cantley, Lewis C, Cox, Adrienne D, Der, Channing J, Stalnecker, Clint A

“…To delineate the mechanisms by which the ERK1 and ERK2 mitogen-activated protein kinases support mutant KRAS-driven cancer growth, we determined the…”
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Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers by Klomp, Jeffrey A, Klomp, Jennifer E, Stalnecker, Clint A, Bryant, Kirsten L, Edwards, A Cole, Drizyte-Miller, Kristina, Hibshman, Priya S, Diehl, J Nathaniel, Lee, Ye S, Morales, Alexis J, Taylor, Khalilah E, Peng, Sen, Tran, Nhan L, Herring, Laura E, Prevatte, Alex W, Barker, Natalie K, Hover, Laura D, Hallin, Jill, Chowdhury, Saikat, Coker, Oluwadara, Lee, Hey Min, Goodwin, Craig M, Gautam, Prson, Olson, Peter, Christensen, James G, Shen, John P, Kopetz, Scott, Graves, Lee M, Lim, Kian-Huat, Wang-Gillam, Andrea, Wennerberg, Krister, Cox, Adrienne D, Der, Channing J

“…How the oncogene drives cancer growth remains poorly understood. Therefore, we established a systemwide portrait of KRAS- and extracellular signal-regulated…”
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CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment by Klomp, Jennifer E, Lee, Ye S, Goodwin, Craig M, Papke, Björn, Klomp, Jeff A, Waters, Andrew M, Stalnecker, Clint A, DeLiberty, Jonathan M, Drizyte-Miller, Kristina, Yang, Runying, Diehl, J Nathaniel, Yin, Hongwei H, Pierobon, Mariaelena, Baldelli, Elisa, Ryan, Meagan B, Li, Siqi, Peterson, Jackson, Smith, Amber R, Neal, James T, McCormick, Aaron K, Kuo, Calvin J, Counter, Christopher M, Petricoin, 3rd, Emanuel F, Cox, Adrienne D, Bryant, Kirsten L, Der, Channing J

“…We apply genetic screens to delineate modulators of KRAS mutant pancreatic ductal adenocarcinoma (PDAC) sensitivity to ERK inhibitor treatment, and we identify…”
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VCP/p97, a pleiotropic protein regulator of the DNA damage response and proteostasis, is a potential therapeutic target in KRAS -mutant pancreatic cancer by Lee, Ye S, Klomp, Jennifer E, Stalnecker, Clint A, Goodwin, Craig M, Gao, Yanzhe, Droby, Gaith N, Vaziri, Cyrus, Bryant, Kirsten L, Der, Channing J, Cox, Adrienne D

“…We and others have recently shown that proteins involved in the DNA damage response (DDR) are critical for -mutant pancreatic ductal adenocarcinoma (PDAC) cell…”
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Mimicking transient activation of protein kinases in living cells by Klomp, Jennifer E., Huyot, Vincent, Ray, Anne-Marie, Collins, Kerrie B., Malik, Asrar B., Karginov, Andrei V.

“…Physiological stimuli activate protein kinases for finite periods of time, which is critical for specific biological outcomes. Mimicking this transient…”
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Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition by Waters, Andrew M., Khatib, Tala O., Papke, Bjoern, Goodwin, Craig M., Hobbs, G. Aaron, Diehl, J. Nathaniel, Yang, Runying, Edwards, A. Cole, Walsh, Katherine H., Sulahian, Rita, McFarland, James M., Kapner, Kevin S., Gilbert, Thomas S.K., Stalnecker, Clint A., Javaid, Sehrish, Barkovskaya, Anna, Grover, Kajal R., Hibshman, Priya S., Blake, Devon R., Schaefer, Antje, Nowak, Katherine M., Klomp, Jennifer E., Hayes, Tikvah K., Kassner, Michelle, Tang, Nanyun, Tanaseichuk, Olga, Chen, Kaisheng, Zhou, Yingyao, Kalkat, Manpreet, Herring, Laura E., Graves, Lee M., Penn, Linda Z., Yin, Hongwei H., Aguirre, Andrew J., Hahn, William C., Cox, Adrienne D., Der, Channing J.

“…To identify therapeutic targets for KRAS mutant pancreatic cancer, we conduct a druggable genome small interfering RNA (siRNA) screen and determine that…”
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Dissecting Kinase Effector Signaling Using the RapRTAP Methodology by Ray, Anne-Marie, Klomp, Jennifer E, Collins, Kerrie B, Karginov, Andrei V

“…Kinases are involved in a broad spectrum of cell behaviors. A single kinase can interact with different ligands each eliciting a specific cellular response…”
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Author Correction: Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer by Bryant, Kirsten L., Stalnecker, Clint A., Zeitouni, Daniel, Klomp, Jennifer E., Peng, Sen, Tikunov, Andrey P., Gunda, Venugopal, Pierobon, Mariaelena, Waters, Andrew M., George, Samuel D., Tomar, Garima, Papke, Björn, Hobbs, G. Aaron, Yan, Liang, Hayes, Tikvah K., Diehl, J. Nathaniel, Goode, Gennifer D., Chaika, Nina V., Wang, Yingxue, Zhang, Guo-Fang, Witkiewicz, Agnieszka K., Knudsen, Erik S., Petricoin, Emanuel F., Singh, Pankaj K., Macdonald, Jeffrey M., Tran, Nhan L., Lyssiotis, Costas A., Ying, Haoqiang, Kimmelman, Alec C., Cox, Adrienne D., Der, Channing J.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Cloacal microbial communities of female spotted towhees Pipilo maculatus: microgeographic variation and individual sources of variability by Klomp, Jennifer E, Murphy, Michael T, Smith, Sarah Bartos, McKay, Jenny E, Ferrera, Isabella, Reysenbach, Anna-Louise

“…We used Polymerase Chain Reaction (PCR) amplification of 16S rRNA genes and Denaturing Gradient Gel Electrophoresis (DGGE) to describe the microbial…”
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Abstract PR10: Enhancing the effect of autophagy inhibition for pancreatic cancer treatment by Bryant, Kirsten L., Klomp, Jennifer E., Lee, Ye S., Stalnecker, Clint A., Grover, Kajal R., Edwards, A. Cole, Peng, Sen, Pierobon, Mariaelena, Petricoin, Emanuel F., Tran, Nhan, Kimmelman, Alec C., Cox, Adrienne D., Der, Channing J.

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by KRAS- and autophagy-dependent tumorigenic growth. We determined the role of mutationally…”
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Abstract B034: Determination of KRAS- and ERK-regulated phosphoproteomes in KRAS-mutant cancers by Klomp, Jennifer E., Klomp, Jeff A., Diehl, Nathaniel J., Edwards, Cole A., Drizyte-Miller, Kristina, Hibshman, Priya S., Yang, Runying, Morales, Alexis J., Taylor, Khalilah E., Pierobon, Mariaelena, Petricoin, Emanuel F., Jared, Johnson L., Huntsman, Emily M., Yaron, Tomer M., Vähä-Koskela, Markus, Herring, Laura E., Prevatte, Alex W., Barker, Natalie K., Graves, Lee M., Krister, Wennerberg, Cantley, Lewis C., Christensen, James G., Cox, Adrienne D., Der, Channing J., Stalnecker, Clint A.

“…Abstract Direct inhibitors of mutationally activated KRAS are currently under intense preclinical and clinical development, with one KRASG12C mutant-selective…”
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