Search Results - "Klomp, Jeffrey A"

TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors by Edwards, A Cole, Stalnecker, Clint A, Jean Morales, Alexis, Taylor, Khalilah E, Klomp, Jennifer E, Klomp, Jeffrey A, Waters, Andrew M, Sudhakar, Niranjan, Hallin, Jill, Tang, Tracy T, Olson, Peter, Post, Leonard, Christensen, James G, Cox, Adrienne D, Der, Channing J

“…Primary/intrinsic and treatment-induced acquired resistance limit the initial response rate to and long-term efficacy of direct inhibitors of the KRASG12C…”
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Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer by Klomp, Jennifer E, Diehl, J Nathaniel, Klomp, Jeffrey A, Edwards, A Cole, Yang, Runying, Morales, Alexis J, Taylor, Khalilah E, Drizyte-Miller, Kristina, Bryant, Kirsten L, Schaefer, Antje, Johnson, Jared L, Huntsman, Emily M, Yaron, Tomer M, Pierobon, Mariaelena, Baldelli, Elisa, Prevatte, Alex W, Barker, Natalie K, Herring, Laura E, Petricoin, 3rd, Emanuel F, Graves, Lee M, Cantley, Lewis C, Cox, Adrienne D, Der, Channing J, Stalnecker, Clint A

“…To delineate the mechanisms by which the ERK1 and ERK2 mitogen-activated protein kinases support mutant KRAS-driven cancer growth, we determined the…”
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Stromal reprogramming overcomes resistance to RAS-MAPK inhibition to improve pancreas cancer responses to cytotoxic and immune therapy by Liu, Xiuting, Baer, John M, Stone, Meredith L, Knolhoff, Brett L, Hogg, Graham D, Turner, Madeleine C, Kao, Yu-Lan, Weinstein, Alyssa G, Ahmad, Faiz, Chen, Jie, Schmidt, Andrew D, Klomp, Jeffrey A, Coho, Heather, Coho, Kayjana S, Coma, Silvia, Pachter, Jonathan A, Bryant, Kirsten L, Kang, Liang-I, Lim, Kian-Huat, Beatty, Gregory L, DeNardo, David G

“…Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that is often resistant to therapy. An immune suppressive tumor microenvironment (TME) and…”
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Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers by Klomp, Jeffrey A, Klomp, Jennifer E, Stalnecker, Clint A, Bryant, Kirsten L, Edwards, A Cole, Drizyte-Miller, Kristina, Hibshman, Priya S, Diehl, J Nathaniel, Lee, Ye S, Morales, Alexis J, Taylor, Khalilah E, Peng, Sen, Tran, Nhan L, Herring, Laura E, Prevatte, Alex W, Barker, Natalie K, Hover, Laura D, Hallin, Jill, Chowdhury, Saikat, Coker, Oluwadara, Lee, Hey Min, Goodwin, Craig M, Gautam, Prson, Olson, Peter, Christensen, James G, Shen, John P, Kopetz, Scott, Graves, Lee M, Lim, Kian-Huat, Wang-Gillam, Andrea, Wennerberg, Krister, Cox, Adrienne D, Der, Channing J

“…How the oncogene drives cancer growth remains poorly understood. Therefore, we established a systemwide portrait of KRAS- and extracellular signal-regulated…”
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Exploring the Molecular Genetics of Oncocytic Kidney Tumors by Klomp, Jeffrey A

“…Kidney cancer remains as one of the most frequently occuring types of cancer in the world with high mortality in advanced forms. To better understand the…”
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