Search Results - "Klok, Rob P"

Evaluation of [11 C]laniquidar as a tracer of P-glycoprotein: radiosynthesis and biodistribution in rats by Luurtsema, Gert, Schuit, Robert C, Klok, Rob P, Verbeek, Joost, Leysen, Josée E, Lammertsma, Adriaan A, Windhorst, Albert D

“…Abstract At present, P-glycoprotein (P-gp) function can be studied using positron emission tomography (PET) together with a labelled P-gp substrate such as ( R…”
Get full text

Radiosynthesis and biodistribution of a histamine H3 receptor antagonist 4-[3-(4-piperidin-1-yl-but-1-ynyl)-[11C]benzyl]-morpholine: evaluation of a potential PET ligand by Airaksinen, Anu J, Jablonowski, Jill A, van der Mey, Margreet, Barbier, Ann J, Klok, Rob P, Verbeek, Joost, Schuit, Robert, Herscheid, Jacobus D M, Leysen, Josee E, Carruthers, Nicholas I, Lammertsma, Adriaan A, Windhorst, Albert D

“…The potent histamine H(3) receptor antagonist JNJ-10181457 (1) was successfully labeled with (11)C in a novel one-pot reaction sequence, with high chemical…”
Get full text

Zirconium-Labeled Monoclonal Antibodies and Their Distribution in Tumor-Bearing Nude Mice by Meijs, Wilma E, Haisma, Hidde J, Klok, Rob P, van Gog, Frank B, Kievit, Els, Pinedo, Herbert M, Herscheid, Jacobus D.M

“…A method to label monoclonal antibodies (MAbs) with 88Zr and 89Zr has been developed and tested on the MAbs 323/A3 and E48. The bifunctional chelating agent…”
Get full text

Synthesis and evaluation of radiolabeled analogs of the antidepressant drug zimelidine as potential SPECT-ligands for the serotonin transporter by Eersels, Jos L.H., Klok, Rob P., Verbeek, Joost, Jonker, Allard J., Herscheid, Jacobus D.M.

“…Z-3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridinyl)-2-propen-1-amine or zimelidine (ZIM) and its first metabolite nor-zimelidine, were radioiodinated via a…”
Get full text

Radiosynthesis and biodistribution of a histamine H 3 receptor antagonist 4-[3-(4-piperidin-1-yl-but-1-ynyl)-[ 11C]benzyl]-morpholine: evaluation of a potential PET ligand by Airaksinen, Anu J., Jablonowski, Jill A., van der Mey, Margreet, Barbier, Ann J., Klok, Rob P., Verbeek, Joost, Schuit, Robert, Herscheid, Jacobus D.M., Leysen, Josee E., Carruthers, Nicholas I., Lammertsma, Adriaan A., Windhorst, Albert D.

“…The potent histamine H 3 receptor antagonist JNJ-10181457 ( 1 ) was successfully labeled with 11C in a novel one-pot reaction sequence, with high chemical…”
Get full text

Evaluation of [ 18 F]VUF 5000 as a potential PET ligand for brain imaging of the histamine H 3 receptor by Windhorst, Albert D., Timmerman, Henk, Klok, Rob P., Menge, Wiro M.P.B., Leurs, Rob, Herscheid, Jacobus D.M.

Get full text

Optimal quality (131)I-monoclonal antibodies on high-dose labeling in a large reaction volume and temorarily coating the antibody with IODO-GEN by Visser, Gerard W, Klok, Rob P, Klein Gebbinck, Jacqueline W, Tom ter Linden

“…A novel, facile procedure for efficient coupling of high doses of (131)I to monoclonal antibodies (MAbs) was developed with minimal chemical and radiation…”
Get full text

Evaluation of [18F]VUF 5000 as a potential PET ligand for brain imaging of the histamine H3 receptor by WINDHORST, A. D, TIMMERMAN, H, KLOK, R. P, MENGE, W. M. P. B, LEURS, R, HERSCHEID, J. D. M

“…[18F]VUF 5000 was evaluated as a potential PET ligand for the histamine H3 receptor. In the rat a high uptake of [18F]VUF 5000 was observed in liver, lung and…”
Get full text

Optimal Quality 131I-Monoclonal Antibodies on High-Dose Labeling in a Large Reaction Volume and Temporarily Coating the Antibody with IODO-GEN by Visser, Gerard W, Klok, Rob P, Gebbinck, Jacqueline W. Klein, ter Linden, Tom, van Dongen, Guus A, Molthoff, Carla F

Get full text

A facile method for the labeling of proteins with zirconium isotopes by Meijs, Wilma E., Haisma, Hidde J., Van Der Schors, Roel, Wijbrandts, René, Van Den Oever, Karin, Klok, Rob P., Pinedo, Herbert M., Herscheid, Jacobus D.M.

“…To label proteins with positron emitters with a half-life in the order of days, a method has been developed to label proteins with zirconium (Zr)-isotopes…”
Get full text

Radiosynthesis and biodistribution of 123I-labeled antagonists of the histamine H 3 receptor as potential SPECT ligands by Windhorst, Albert D., Timmerman, Henk, Klok, Rob P., Custers, Franciscus G.J., Menge, Wiro M.P.B., Leurs, Rob, Stark, Holger, Schunack, Walter, Gielen, Eric G.J., van Kroonenburgh, Marinus J.P.G., Herscheid, Jacobus D.M.

“…We have synthesized three 123I-labeled histamine H 3 receptor ligands, i.e., [ 123I]GR 190028, [ 123I]FUB 271, and [ 123I]iodoproxyfan, in moderate to good…”
Get full text

Radiosynthesis and biodistribution of 123I-labeled antagonists of the histamine H3 receptor as potential SPECT ligands by WINDHORST, A. D, TIMMERMAN, H, HERSCHEID, J. D. M, KLOK, R. P, CUSTERS, F. G. J, MENGE, W. M. P. B, LEURS, R, STARK, H, SCHUNACK, W, GIELEN, E. G. J, VAN KROONENBURGH, M. J. P. G

“…We have synthesized three 123I-labeled histamine H3 receptor ligands, i.e., [123I]GR 190028, [123I]FUB 271, and [123I]iodoproxyfan, in moderate to good…”
Get full text