Search Results - "Klok, Melanie D."

Corticosteroid receptor-gene variants: Modulators of the stress-response and implications for mental health by DeRijk, Roel H., van Leeuwen, Nienke, Klok, Melanie D., Zitman, Frans G.

“…The stress-response, including autonomic and hypothalamic–pituitary–adrenal (HPA) axis reactivity, is essential for maintaining homeostasis during a challenge…”
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Illegitimate WNT Signaling Promotes Proliferation of Multiple Myeloma Cells by Patrick W. B. Derksen, Tjin, Esther, Meijer, Helen P., Klok, Melanie D., Harold D. Mac Gillavry, Marinus H. J. van Oers, Lokhorst, Henk M., Bloem, Andries C., Clevers, Hans, Nusse, Roel, van der Neut, Ronald, Spaargaren, Marcel, Pals, Steven T., Weissman, Irving L.

“…The unrestrained growth of tumor cells is generally attributed to mutations in essential growth control genes, but tumor cells are also influenced by signals…”
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Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma by Tjin, Esther P.M., Groen, Richard W.J., Vogelzang, Irma, Derksen, Patrick W.B., Klok, Melanie D., Meijer, Helen P., van Eeden, Susanne, Pals, Steven T., Spaargaren, Marcel

“…Inappropriate activation of MET, the receptor tyrosine kinase for hepatocyte growth factor (HGF), has been implicated in tumorigenesis. Although we have…”
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Differential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed by Alt, Simone R, Turner, Jonathan D, Klok, Melanie D, Meijer, Onno C, Lakke, Egbert A.J.F, DeRijk, Roel H, Muller, Claude P

“…Summary Hyperactivity of the hypothalamic–pituitary–adrenal (HPA) axis is one of the most consistent findings in major depressive disorder (MDD). Impaired HPA…”
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Decreased expression of mineralocorticoid receptor mRNA and its splice variants in postmortem brain regions of patients with major depressive disorder by Klok, Melanie D, Alt, Simone R, Irurzun Lafitte, Alicia J.M, Turner, Jonathan D, Lakke, Egbert A.J.F, Huitinga, Inge, Muller, Claude P, Zitman, Frans G, Ronald de Kloet, E, DeRijk, Roel H

“…Abstract Appropriate signaling in the brain by the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) is critical in regulation of the…”
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The B Cell Antigen Receptor Controls Integrin Activity through Btk and PLCγ2 by Spaargaren, Marcel, Beuling, Esther A., Rurup, Mette L., Meijer, Helen P., Klok, Melanie D., Middendorp, Sabine, Hendriks, Rudolf W., Pals, Steven T.

“…Integrin-mediated adhesion and B cell antigen receptor (BCR) signaling play a critical role in B cell development and function, including antigen-specific B…”
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Common functional mineralocorticoid receptor polymorphisms modulate the cortisol awakening response: Interaction with SSRIs by Klok, Melanie D, Vreeburg, Sophie A, Penninx, Brenda W.J.H, Zitman, Frans G, de Kloet, E. Ron, DeRijk, Roel H

“…Summary Background Cortisol controls the activity of the hypothalamic–pituitary–adrenal (HPA) axis during stress and during the circadian cycle through central…”
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Axonal abnormalities in vanishing white matter by Klok, Melanie D., Bugiani, Marianna, de Vries, Sharon I., Gerritsen, Wouter, Breur, Marjolein, Sluis, Sophie, Heine, Vivi M., Kole, Maarten H. P., Baron, Wia, Knaap, Marjo S.

“…Objective We aimed to study the occurrence and development of axonal pathology and the influence of astrocytes in vanishing white matter. Methods Axons and…”
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Interferon‐α and the calcifying microangiopathy in Aicardi–Goutières syndrome by Klok, Melanie D., Bakels, Hannah S., Postma, Nienke L., Spaendonk, Rosalina M. L., Knaap, Marjo S., Bugiani, Marianna

“…Aicardi–Goutières syndrome is a leukoencephalopathy with calcifications and increased cerebrospinal fluid interferon‐α. The relation between interferon‐α and…”
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Functional analysis of HGFf/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma by TJIN, Esther P. M, GROEN, Richard W. J, VOGELZANG, Irma, DERKSEN, Patrick W. B, KLOK, Melanie D, MEIJER, Helen P, VAN EEDEN, Susanne, PALS, Steven T, SPAARGAREN, Marcel

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The B cell antigen receptor controls integrin activity through Btk and PLCgamma2 by Spaargaren, Marcel, Beuling, Esther A, Rurup, Mette L, Meijer, Helen P, Klok, Melanie D, Middendorp, Sabine, Hendriks, Rudolf W, Pals, Steven T

“…Integrin-mediated adhesion and B cell antigen receptor (BCR) signaling play a critical role in B cell development and function, including antigen-specific B…”
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