Search Results - "Klohs, Wayne D"

Plasma vascular endothelial growth factor and interleukin-8 as biomarkers of antitumor efficacy of a prototypical erbB family tyrosine kinase inhibitor by Christensen, James G, Vincent, Patrick W, Klohs, Wayne D, Fry, David W, Leopold, Wilbur R, Elliott, William L

“…CI-1033 ( N -[4-[ N -(3-chloro-4-fluorophenyl)amino-7-[3-(4-morpholynyl)propoxy]quinazolin-6-yl]acrylamide, PD 0183805-mesylate salt) was identified as a…”
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Antiangiogenic agents by Klohs, Wayne D, Hamby, James M

“…A greater understanding of the complex process of tumor-induced angiogenesis, coupled with the notion that tumors require a blood supply to both grow and…”
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Inhibitors of tyrosine kinase by Klohs, Wayne D, Fry, David W, Kraker, Alan J

“…This review covers the literature on significant studies of small molecule inhibitors of the epidermal growth factor receptor (EGFR), platelet-derived growth…”
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2-Substituted Aminopyrido[2,3-d]pyrimidin-7(8H)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity by Klutchko, Sylvester R, Hamby, James M, Boschelli, Diane H, Wu, Zhipei, Kraker, Alan J, Amar, Aneesa M, Hartl, Brian G, Shen, Cynthia, Klohs, Wayne D, Steinkampf, Randall W, Driscoll, Denise L, Nelson, James M, Elliott, William L, Roberts, Billy J, Stoner, Chad L, Vincent, Patrick W, Dykes, Donald J, Panek, Robert L, Lu, Gina H, Major, Terry C, Dahring, Tawny K, Hallak, Hussein, Bradford, Laura A, Showalter, H. D. Hollis, Doherty, Annette M

“…While engaged in therapeutic intervention against a number of proliferative diseases, we have discovered the 2-aminopyrido[2,3-d]pyrimidin-7(8H)-ones as a…”
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Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines:  Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors by Boschelli, Diane H, Wu, Zhipei, Klutchko, Sylvester R, Showalter, H. D. Hollis, Hamby, James M, Lu, Gina H, Major, Terry C, Dahring, Tawny K, Batley, Brian, Panek, Robert L, Keiser, Joan, Hartl, Brian G, Kraker, Alan J, Klohs, Wayne D, Roberts, Bill J, Patmore, Sandra, Elliott, William L, Steinkampf, Randy, Bradford, Laura A, Hallak, Hussein, Doherty, Annette M

“…Screening of a compound library led to the identification of 2-amino-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidine (1) as a inhibitor of the…”
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Discovery and structure-activity studies of a novel series of pyrido[2,3- d]pyrimidine tyrosine kinase inhibitors by Connolly, Cleo J.C., Hamby, James M., Schroeder, Mel C., Barvian, Mark, Lu, Gina H., Panek, Robert L., Amar, Aneesa, Shen, Cindy, Kraker, Alan J., Fry, David W., Klohs, Wayne D., Doherty, Annette M.

“…The inhibition of tyrosine kinase-mediated signal transduction pathways represents a therapeutic approach to the intervention of proliferative diseases such as…”
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Resistance to anthrapyrazoles and anthracyclines in multidrug-resistant P388 murine leukemia cells: reversal by calcium blockers and calmodulin antagonists by KLOHS, W. D, STEINKAMPF, R. W, HAVLICK, M. J, JACKSON, R. C

“…A series of anthrapyrazoles was examined for their cytotoxic effect on P388 cells resistant (P388R) to anthracyclines, N-[4-(9-acridinylamino)-3-methoxyphenyl]…”
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Possible link between the intrinsic drug resistance of colon tumors and a detoxification mechanism of intestinal cells by KLOHS, W. D, STEINKAMPF, R. W

“…The insensitivity of colon tumors to various anticancer agents was studied in vitro. The activity of Adriamycin (ADR) in several colon tumor cell lines was…”
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Effects of nucleotides and nucleotide:analogs on human serum sialyltransferase by Klohs, W D, Bernacki, R J, Korytnyk, W

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Release of glycosyltransferase and glycosidase activities from normal and transformed cell lines by Klohs, W D, Mastrangelo, R, Weiser, M M

“…The release of galactosyltransferase, sialyltransferase, and several glycosidase activities into the growth media from several normal and transformed cell…”
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Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8 H -pyrido[2,3- d ]pyrimidines:  Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors by Boschelli, Diane H., Wu, Zhipei, Klutchko, Sylvester R., Showalter, H. D. Hollis, Hamby, James M., Lu, Gina H., Major, Terry C., Dahring, Tawny K., Batley, Brian, Panek, Robert L., Keiser, Joan, Hartl, Brian G., Kraker, Alan J., Klohs, Wayne D., Roberts, Bill J., Patmore, Sandra, Elliott, William L., Steinkampf, Randy, Bradford, Laura A., Hallak, Hussein, Doherty, Annette M.

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Role of a small molecular weight phosphoprotein in the mechanism of action of CI-994 (N-acetyldinaline) by Rummel, S A, Kraker, A J, Steinkampf, R W, Hook, K E, Klohs, W D

“…The mechanism of action of the novel anti-cancer compound CI-994 was studied in C26 murine colon tumor and HCT-8 human colon adenocarcinoma cells. Treatment of…”
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Cross resistance of pleiotropically drug resistant P338 leukemia cells to the lipophilic antifolates trimetrexate and BW 301U by Klohs, W D, Steinkampf, R W, Besserer, J A, Fry, D W

“…Several antifolate compounds were examined for their cytotoxic activity in a pleiotropically resistant P388 cell line (P388R). The sensitivity of P388R cells…”
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UDP-galactose inhibition of BALB/3T12-3 cell growth. Requirement for medium galactosyltransferase activity by Klohs, W D, Wilson, J R, Weiser, M M

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Collagen-production inhibitors evaluated as antitumor agents by Klohs, W D, Steinkampf, R W, Wicha, M S, Mertus, A E, Tunac, J B, Leopold, W R

“…Proline analogues such as cis-4-hydroxy-L-proline (CHP) and L-azetidine-2-carboxylic acid (A2C) were tested for their antitumor activity in tissue culture and…”
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Phenyl 2-acetamido-2-deoxy-3-O-beta-D-galactopyranosyl-alpha-D-galactopyranoside, a substrate for sialyltransferase by Klohs, W D, Matta, K L, Barlow, J J, Bernacki, R J

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Decrease by cycloheximide of calcium binding and nonesterified fatty acids in rat-intestinal Golgi-enriched membrane fractions by Dasmahapatra, A, Walters, J R, Weiser, M M, Bloor, J H, Klohs, W D

“…Rat intestinal Golgi-enriched membrane fractions bind more Ca2+ than do basolateral and microvillus-enriched membrane fractions, and this uptake is reduced by…”
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Evaluation of galactosyltransferase isoenzyme II in a human colon carcinoma-derived cell line, HCT-8 by Klohs, W D, Chi, T T, Steinkampf, R W, Tunac, J B

“…Polyacrylamide gel electrophoresis of galactosyltransferase (GT) extracted from a human colon adenocarcinoma cell line, HCT-8, demonstrated the presence of two…”
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